Haematological Changes in Systemic Disease (036)

Questions

1) Major causes of neutrophilia

2) Left-shifted reaction means ?

3)Leucoerythroblastic change causes ;

4)If a patient presents will leucoerythroblastic blood, what's next investigation?

5)Isolated neutropenia causing drugs

6) What type of neutrophils are found in MDS ?

7) What deficiencys cause bleeding tendencies?

8) What can cause bleeding tendencies:

9) What is serum sickness?

10) What is a mallory-weiss tear?

Answers:

1) Bacterial infection (localised or

disseminated), inflammation, myeloproliferative disease,

necrosis, malignant disease, corticosteroids

2) poly morph "regresses "so we have (band, metamyelo, promyelo, myeloclast)

3)Marrow invasion or severe illness

4) Bone marrow aspirate & trephine biopsy

5)Co-trimaxarde, carbimacole, Anti-psychotics, phenylbutazone,cytotoxic drugs

6) Hypogranular neutrophils

7) vit.K dependent factors, II, VII, IX, & also V: fibrinogen

8) Abnormalities of Fibrinogen, ^fibrinolytic activity decreased platelets (hypersplenism), direct effect of alcohol), portal hypertension

9) Type III hypersensitivity reaction

10) A tear in the mucosal layer at the junction of the esophagus & stomach