Into to ADME ( Week 2 L2 )

How the drug gets into systemic blood from it’s formulation at the administered site

Drug and formulation properties determining absorption

Distribution

Reversible transfer of drug between the blood (or other site of measurement) and other tissues within the body

• Determines drug concentration in the blood plasma and different tissues

*Unbound drug concentration drives effect

• Different drugs have effects in different tissues

Distribution: Plasma protein binding

• Unbound drug concentration drives effect

Drug metabolism

Biotransformation of the drug into another chemical species