Pharmacokinetics of Allopurinol

Pharmacokinetics of Allopurinol

Absorption

• Well absorbed by the body.

Metabolism

• Hepatic metabolism produces oxypurinol.

• Oxypurinol: a weak xanthine oxidase inhibitor.

Drug Interactions

• 6-Mercaptopurine (active metabolite of Azathioprine): Allopurinol decreases its breakdown, leading to potential severe toxicity (hematopoietic and mucosal).

• Warfarin: Metabolism is inhibited by Allopurinol.