Clotting Cascade

Factor 1 (fibrinogen) - fibrin

Factor 2 (prothrombin) - thrombin via Ca2+

Factor 3 (tissue factor) - extrinsic pathway

Factor 4 (calcium) - calcium and prothrombin

Factor 5 (proaccelerin) - thrombin

Factor 6 - extrinsic pathway

Factor 7 (proconvertin) - extrinsic pathway with F3 and F4

Factor 8 (antihaemophilic) - intrinsic pathway and tenase complex to F10

Factor 9 (Christmas) - intrinsic pathway and tenase complex with F8 to F10

Factor 10 (Stuart-Prower) - by tenase complex to prothrombin→thrombin

Factor 11 (PTA) - intrinsic pathway to activate F9

Factor 12 (Hageman) - intrinsic pathway, activates F11 to activate fibrinolytic system

Factor 13 (fibrin stabilising) - stabilises fibrin