krebs cycle U.2 L.4

  • steps to pyruvate oxidartion :

    1. Pyruvate is converted into acetyl-CoA (acetyl coenzyme A). CoA is a carrier molecule.

    2. The acetyl group is a 2-carbon molecule; one carbon is released as CO2.

    3. The conversion reactions are linked to the reduction of NAD+ to produce NADH.  

    4. Two NADH and acetyl-CoA are produced for every glucose molecule. 

    5. Acetyl-CoA is then fed into the Krebs cycle for oxidization.

  • steps of the krebs cycle :

    1: Acetyl-CoA brings its 2 carbons and joins with oxaloacetate to produce citrate.

    2-3: Isomerization of citrate to isocitrate.

    4-5: Oxidation reactions that result in CO2. Each oxidation reaction is coupled to a reduction reaction that produces one molecule of NADH.

    6: Substrate-level phosphorylation occurs in a complex reaction involving GTP to produce one molecule of ATP.

    7: Oxidation reaction is coupled to a reduction reaction to produce one molecule of FADH2.

    8-9: Regeneration of oxaloacetate from a coupled redox reaction produces one molecule of NADH.