MBBS I Sample Questions Study Notes

MBBS I Sample Questions

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November 2025

Table of Contents

  1. SECTION A: MULTIPLE CHOICE QUESTIONS

    • IASM Block

    • CPRS Block

  2. SECTION A: EXTENDED MATCHING QUESTIONS

    • IASM Block

    • CPRS Block

  3. SECTION A: STRUCTURED ANSWER QUESTIONS

    • IASM Block

    • CPRS Block

  4. SECTION B: MULTIPLE CHOICE QUESTIONS

    • IASM Block

    • CPRS Block

  5. SECTION B: EXTENDED MATCHING QUESTIONS

    • IASM Block

    • CPRS Block

  6. SECTION B: STRUCTURED ANSWER QUESTIONS

    • IASM Block

    • CPRS Block

SECTION A: MULTIPLE CHOICE QUESTIONS

IASM Block
IASA1008 Item ID: 25622

Question: Hair growth occurs in a cycle. What is the average length of the anagen phase in hair growth?
A. 3 days
B. 3 weeks
C. 3 months
D. 3 years
Answer: D

  • Follow-up Questions:

    • What are the three stages of hair growth?

    • What happens at those three stages respectively?

    • What is the percentage of hair follicles in each stage?

    • What is the length of each hair cycle, including eyebrows?

IASA1013 Item ID: 27647

Question: There are different types of cells in the nervous system. Dysfunctional apical cilia of which type of cells may alter choroid plexus function and lead to hydrocephalus?
A. Astrocytes
B. Ependymal cells
C. Microglia
D. Schwann cells
Answer: B

  • Follow-up Question: What is special about ependymal cells compared to other glial cells?

IASA1017 Item ID: 25969

Question: In vitro fertilisation can help carriers of genetic diseases. Which reproductive technology leads to babies with genetic material from three individuals?
A. CRISPR/Cas9
B. Embryo splitting
C. Mitochondrial replacement
D. Sperm donation
Answer: C

  • Follow-up Questions:

    • Is it maternally or paternally inherited?

    • Is it possible that normal and mutant cells coexist?

    • Which belongs to whom (egg nucleus, egg mitochondria, sperm)?

IASA1018 Item ID: 27563

Question: Deficiency of vitamin C leads to scurvy. Vitamin C is required for which protein post-translational modification?
A. Cysteine oxidation
B. Lysine methylation
C. Proline hydroxylation
D. Tyrosine phosphorylation
Answer: C

  • Follow-up Questions:

    • What is the function of vitamin C in this scenario?

    • Which enzyme is sustained?

IASA1019 Item ID: 27568

Question: The mammalian cell cycle can be stopped at specific checkpoints when sensing unfavorable signals. When DNA replication is incomplete, the cell cycle arrests at which of the following checkpoints?
A. G0
B. G1
C. G2
D. M
Answer: C

  • Follow-up Questions:

    • Which two proteins control this cell activity?

    • What are the functions of each respective protein?

    • What is the trigger to this reaction?

IASA1021 Item ID: 27564

Question: Many diseases are associated with defects in RNA processing. In which cellular compartment does RNA processing mainly occur?
A. Cytoplasm
B. Endoplasmic reticulum
C. Golgi apparatus
D. Nucleus
Answer: D

  • Follow-up Questions:

    • What two processing steps occur in the nucleus?

    • What processes occur in the cytoplasm?

IASA1022 Item ID: 27575

Question: Single gene disorders often show a predictable 'Mendelian' inheritance pattern. Which pattern of affected individuals in a pedigree diagram would suggest an autosomal dominant inheritance?
A. All generations are affected
B. Generations are skipped
C. Only females are affected
D. Only males are affected
Answer: A

IASA1023 Item ID: 27576

Question: Vaccination offers long-lasting antigen-specific immune protection. What is the key cellular mediator responsible for this protection?
A. Antibodies
B. Effector T cells
C. Immature B cells
D. Memory lymphocytes
Answer: D

IASA1024 Item ID: 26097

Question: The human body is made up of several fluid compartments. How do you calculate the intracellular fluid volume of the body?
A. Extracellular fluid volume + interstitial fluid volume - plasma volume
B. Interstitial fluid volume - plasma volume + total body fluid volume
C. Plasma volume + extracellular fluid volume + total body fluid volume
D. Total body fluid volume - plasma volume - interstitial fluid volume
Answer: D

IASA1027 Item ID: 26886

Question: The core body temperature is normally maintained at a relatively constant level by the thermoregulatory centre. What body response occurs when the core body temperature is below the thermal set-point of the thermoregulatory centre?
A. Cutaneous vasodilation
B. Decrease in heat production
C. Shivering
D. Sweating
Answer: C

  • Follow-up Questions:

    • What is the principle for heat production in the body?

    • What are the three ways of heat loss of the body?

    • What is the ONLY way of heat loss in a hotter environment?

SECTION A: EXTENDED MATCHING QUESTIONS

[To be Continued]

This document is ongoing. Multiple choice questions in various biological and medical areas will continue to be documented.