Immunity

Immunity

  • Take medications until completed, as prescribed
  • Don’t stop when you “feel” better
  • Draw all specimens for cultures prior to starting treatment

Appendicitis

  • Inflammation of the appendix.

Review of Anatomy

  • Digestive System
    • Primary Organs
    • Secondary Organs (accessory organs)
  • The organs of the digestive system are separated into the primary organs and the secondary or accessory organs.
  • They work together to ensure proper digestion and absorption of nutrients.
  • The primary organs:
    • Mouth
    • Pharynx
    • Esophagus
    • Stomach
    • Small intestine
    • Large intestine
    • Rectum
    • Anal canal
  • The primary organs form a tube, open at both ends, called the gastrointestinal or GI tract.
  • Food that enters the tract isdigested, its nutrients are absorbed, and the undigested residue is eliminated from the body as waste material called feces.
  • The accessory organs:
    • Teeth
    • Salivary glands
    • Tongue
    • Liver
    • Gallbladder
    • Pancreas
    • Appendix
  • The accessory organs assist in the mechanical or chemical breakdown of ingested food.
  • The appendix, although classified as an accessory organ of digestion and physically attached to the digestive tube, is not functionally important in the digestive process.
  • Inflammation of the appendix is called appendicitis and can be a serious clinical condition and often requires surgery.

Etiology & Pathophysiology & Clinical Manifestations

  • Symptoms vary
  • Diagnosis can be difficult needs to be diagnosed quickly.

Diagnostic Studies

  • CBC with differential
    • What is the CBC going to show? Mild to moderately elevated WBC.
  • Urinalysis
    • UA is only done to rule out other problems.
  • Abdominal x-ray examination
  • Intravenous (IV) pyelogram
  • Abdominal computed tomography scan
  • Abdominal ultrasound

Physical Assessment

  • Pain in the RLQ
    • McBurney’s point (halfway between umbilicus and right iliac crest)
  • Presence of rebound tenderness
  • RLQ guarding
  • Abdominal rigidity
  • Muscle spasms
  • Tachycardia
  • Low-grade fever
Acute appendicitis with perforation
  • Increasing, generalized pain
  • Fever, greater than 100.7
  • Generalized abdominal rigidity
  • Flexed knees
  • Causes what or at risk for developing? Peritonitis.
  • May need antibiotics and fluid prior to surgery.

Interventions & Rationales

  • Pain Medication
  • Slow, diaphragmatic breathing.
  • Positioning

Collaborative Interventions

  • Non-pharmacologic
  • Pharmacologic
  • Surgical
  • Antibiotics
  • If suspected of appendicitis, maintain NPO status in anticipation of surgery. Establish IV access with a larger gauge needle, ex. 18 gauge.
  • Pain is pt concern. Treat pain. Fluids.
  • Act quickly to prevent complications.
  • Laparotomy is usually the surgical procedure done. However, may need to open if complications
  • Treated postop for pain control and given IV antibiotics

Evaluation

  • Vital signs
  • Absence of chills
  • Abdomen (Pre and Post op)
  • Bowel sounds post-surgical
  • Post-op pain controlled.

Cellulitis

  • Disease Process: Infection leads to inflammation.
    • Infection can lead to cellulitis.
    • Cellulitis is an infection of the subcu.

Risk Factors

  • Skin break
  • PAD
  • Diabetes
  • Weakened immune function
  • Past instance(s) of cellulitis
  • Obesity

Assessment

History:
  • Draw a circle with a sharpie around the infected area to note any increase in cellulitis.
  • Need to know where the cellulitis started. Any previous exposures or injuries.
  • Full head-to-toe physical, looking for open or inflamed areas.
  • CBC, wound cultures.
Physical:
  • Look for hot, tender, erythematous, and edematous area with diffuse borders.
  • Chills, fever, and malaise.
Labs/Diagnostics
  • History

Nursing Interventions/Evaluations

Interventions:
  • ABX
  • Affected limb
  • Pain control
  • Monitor
Evaluations (Positive Outcomes):
  • Opposite
    • Teach dosing schedule and to take all of the antibiotics. Advise patients if outpatient, of the adverse reactions associated with cellulitis.
    • May require hospitalization and IV antibiotics.
    • Adverse reactions Know allergies
    • NI – elevate affected limb, monitor for swelling and measures to prevent or decrease swelling. Increased swelling = increased pain. Sensitivity to lower extremities may be present and may need a bed cradle to help while in the bed with covers.
    • Monitor for lymphatic streaking.
    • Use sharpie to mark infection.

Osteomyelitis

Pathophysiology

Risk Factors
  • Indirect entry (hematogenous)
    • Children
    • Older adults
    • Debilitation
    • Hx of skin infections
    • Hemodialysis
    • Sickle cell disease
    • IV drug use
  • Direct entry
    • Open wounds
    • Diabetes
    • Vascular disease
    • Indirect – body’s reaction. Starts in or carried by the blood.
    • Occurs in children <17 and older adults.

Assessment

Subjective
  • History
  • Surgery
  • Nutrition
  • Activity
Objective
  • General
  • Integumentary
  • Musculoskeletal

Clinical Manifestations

Acute Osteomyelitis
Local:
  • Bone pain
  • Swelling
  • Tenderness
  • Warmth
  • Limited movement
Systemic:
  • Fever, chills, night sweats
  • Nausea
  • Malaise
Chronic Osteomyelitis
Local:
  • Bone pain
  • Swelling
  • Warmth
  • Acute is constant bone pain that worsens with activity and is unrelieved with rest,
  • Chronic is an infection that last more than one month

Nursing Interventions

  • Handling of limbs
  • Wound care
  • Body alignment
  • Nonpharmacologic techniques
  • Activities of daily living
  • Passive and active range-of-motion
  • Bed rest for acute
  • Assess pain
  • Handle with care.
Collaborative Interventions
  • Antibiotic Therapy
  • Analgesics
  • PT/OT

Nursing Process: Evaluation

  • Pain
  • Body temperature
  • Improvement
  • Compliance
  • Complications
  • Vancomycin is abx of choice.
  • Peak (30 minutes after dose) and trough (30 minutes before dose). Important to maintain level medication in blood stream.
  • Is there improvement.
  • Draw a circle around the reddened area to note any spreading of the infection.

Otitis Media

Acute OM

  • Common with Upper Respiratory Infection
  • Bacterial and viral infections
  • Fluid secreted from the Eustachian tube
  • OM - Affects tympanum, ossicles, and the space of the middle ear
  • OM with effusion – inflammation of the middle ear with a collection of fluid in middle ear space.
Clinical indicators for acute OM include:
  • Adult
  • Children
    • Children are at a higher risk due to short, straight, flat eustachian tubes.

Correlation to Immunity Concept

Compromised
  • Antecedents
  • Attribute Deficits
  • Negative Consequences
Otitis Media Exemplar Correlation to Immunity Concept
  • Interrelated Concepts
    • Tissue Integrity
    • Comfort
    • Functional ability (hearing)
    • Thermoregulation

Risk Factors for Otitis Media

  • Gender
  • Age – more common in first 24 months of life. Rarely happens after 7 years old.
  • Lifestyle behaviors – propping bottle and going to bed with bottle, exposure to smoke
  • Other illnesses/conditions
  • Early detection and treatment is needed secondary to infection may spread to other organs; 1st place is heart.

Assessment

Comprehensive history
Physical/psychological clinical manifestations
  • rubbing or pulling on ears
  • crying
  • lethargy
  • bulging yellow or red tympanic membranes
  • purulent material in middle ear or drainage from external canal
  • limited or no tympanic movement
  • lymphadenopathy in face and neck
  • temperature 100.7 to as high as 104 degrees
  • hearing and speech delays if otitis media becomes chronic

Diagnostic Assessment

  • Otoscopy
  • C&S of ear drainage
  • Mastoid x-ray

Nursing Process for Otitis Media

Nursing Interventions
  • Primary Prevention
  • Secondary Prevention
Collaborative Interventions
Pharmacologic:
  • Antibiotics
    • amoxicillin, amoxicillin-clavulanate, azithromycin (10-14 days)
    • ceftriaxone IM one time only
  • Oral analgesics
    • ibuprofen or acetaminophen
  • Antipyretics
    • ibuprofen or acetaminophen
  • Antihistamines
  • Anesthetic ear drops
  • Other: herbal pain products
Collaborative Interventions
Non-pharmacologic:
  • Surgical – tympanostomy tubes

Pneumonia

Patho

Etiology

Types

  • Acute infection of the lung parenchyma.
  • Cause is defense mechanisms are broken
    • Aspiration
    • Inhalation
    • Hematogenous spread from primary infection somewhere else
  • Community acquired pneumonia – got in the world
  • Hospital acquired pneumonia – 48 hours or longer after admission to hospital
  • Aspiration – abnormal entry of foreign object from mouth or stomach into the lungs. Unconscious patients are at high risk.
  • Necrotizing - rare complication of bacterial lung infection, usually secondary to Staph
  • Opportunistic – pneumonia in immunocompromised patients – such as pneumocystis jiroveci (PJP) (carinii)or cytomeglavisus (CMV)

Complications

  • Pleurisy
  • Pleural effusion
  • Atelectasis
    • Pleurisy – inflammation of the pleura
    • Effusion – a fluid in the pleural space. In most cases it is sterile and reabsorbed but may require aspiration removal by thoracentesis.
    • Atelectasis - complete or partial collapse of lung or section (lobe) of the lung.

Risk Factors

  • Geriatric
  • Nursing home resident
  • Decreased cough reflex
  • Decreased immune function
  • Decreased LOC
  • Feeding tube
  • Upper respiratory infection

Assessment

  • History
  • Physical
  • Labs/Diagnostics
  • What are three common symptoms of hypoxemia?
    • Restlessness, confusion and agitation
    • Also tachycardia, tachypnea, slight diaphoresis, and mild hypertension.

Assessment

  • History
  • Physical
  • Labs/Diagnostics
    • Xray – shows patterns characteristic of the infecting pathogen and it is important
    • CBC – yes or no
    • ABG (arterial blood gas) or VBG (venous blood gas)
    • Sputum C&S

Plan

  • Breathing – incentive spirometer
  • Diagnostics
  • No complications

Implementation & Evaluation

  • Antibiotics, nutritional therapy – may see weight loss

Interventions (Inc. Collaborative)

  • RN
  • Collaborative

Teaching Interventions

Trauma-Sprain

Key Points for Trauma-Sprain

  • Sprains commonly involve the finger, wrist, knee, and ankle joints
  • The ankle is the most frequently injured joint
  • Sprains are classified according to the degree of ligament damage:
    • First degree
    • Second degree
    • Third degree
      • 1st – tears in only a few fibers, mild tenderness and minimal swelling
      • 2nd –partial disruption of the involved tissue, with more swelling and tenderness
      • 3rd – complete tear of the ligament with moderate to severe swelling
Clinical indicators:
  • Blood vessels
  • WBCs
  • Blood flow
  • inflammatory response
  • Edema
  • Warmth and redness
  • Increased nerve sensitivity and pain
  • Decreased mobility of the joint
Treatment for sprains depends on degree of ligament damage
  • First-degree
  • Second-degree
  • Third-degree

Correlation to Immunity Concept

  • Antecedent
  • Attribute deficit
  • Negative consequences
Interrelated Concepts
  • Tissue integrity
  • Comfort
  • Mobility
  • Functional ability

Nursing Process for Trauma-Sprain

Assessment
  • Comprehensive history
  • Review of risk factors
  • Etiology of current injury
  • Previous injury
  • Current medications
Diagnostic Tests
  • X-ray
  • CT scan
  • MRI
Nursing Interventions
  • Primary Prevention
  • Secondary Prevention
  • Tertiary Prevention
Critical Skills
Collaborative Interventions
Pharmacologic
Non-pharmacologic
  • RICE
Surgical
Evaluation
  • Pain
  • Understanding of teaching.
  • Demonstration of assistive devices
  • Lifestyle modifications

Urinary Tract Infection

Disease Process

Definition
  • Infection of urinary system
  • E coli and Candida albicans most common
  • Urinary tract is sterile a change in any of defense mechanisms can cause UTI
    • Class as complicated (normal urinary system) and uncomplicated *(when patient has a problem)
    • Lower uti symptoms (LUTS)
    • CAUTI Anatomy and terms
  • Class: Upper vs. Lower UTI
Pathophysiology
Risk Factors
  • Gender – female more than male
  • Age – the older the more incidences
  • Other illnesses/conditions
  • Lifestyle behaviors
Assessment
  • History
  • Physical
  • Labs/Diagnostics
  • Midstream Clean Catch – know what this is and steps to obtain Midstream
    • Clean urethral opening
    • Void
Plan
  • Relief from Lower UTI’s.
  • Sulfa abx – increase fluids and watch for GI symptoms
  • Early treatment is needed to prevent developing upper UTI.
  • Prevention of recurrence.
  • Nitrofurantoin (Macrodantin) – used for chronic UTIs
Implementation & Evaluation
  • Interventions (Inc. Collaborative)
  • Nursing Collaborative
  • Evaluation (Positive Outcomes)

Immunizations (Vaccines)

Types of Immunity r/t Immunizations

  • Active immunity - exposed to disease and build antibodies in response, ex. flu vaccine, varicella. This is either in the form of having the disease and forming antibodies from that or getting the modulated disease and forming antibodies
  • Passive immunity - antibodies acquired by receiving the antibodies – baby from nursing mother and/or receiving the antibodies such as IgG injections
    • Immune response
    • Vaccine Preventable Diseases
    • At risk populations
    • Role of immunizations

Vaccines Available

Vaccines for bacterial infections
  • Diphtheria
  • Tetanus
  • Pertussis
  • Haemophilus influenza B (Hib)
  • Pneumococcal conjugate
  • Meningitis
Vaccines Available
  • Measles
  • Mumps
  • Rubella
  • Varicella
  • Polio
  • HPV
  • Hepatitis A
  • Hepatitis B
  • Rotovirus
  • Influenza
  • Shingles
  • COVID-19

Vaccines for Active Immunity

  • Inactivated or killed vaccines
  • Attenuated or live vaccines
  • Toxoids
  • Recombinant vaccines
  • Conjugate vaccines
  • Boosters

Antibodies for Passive Immunity

  • Maternal antibodies
  • Immunoglobulins
  • Antivenoms

Knowledge and Concerns

  • Safety
  • Risk for adverse effects
  • Multiple vaccines at once
  • Monitoring by CDC
  • Necessity
  • Protection

Contraindications

  • Age
  • Immunosuppression
  • Allergies
  • Pregnancy
  • History of seizures
  • Certain recent medications
  • Acute illness
    • Reasons for withholding vaccines come in two varieties: precautions and actual contraindications . A precaution is when a person might be at increased risk for complications if he or she is vaccinated. A decision is made by the physician to immunize or not based on the relative benefit to the person weighed against the possible risks. A contraindication is a situation when a person should not be given the immunization.
    • Allergic reactions to the vaccine itself or to certain antibiotics, gelatin, and chicken or eggs are contraindications for specific vaccines if the reaction was one of anaphylaxis. For less severe allergic reactions it is a precaution.
    • Immunoglobulin infusion in the past six months or blood transfusion in the last year are contraindications because either case may result in failure of the person to develop immunity.
    • A severely immunosuppressed person or a pregnant individual are not given live virus vaccines (contraindicated). Specific protocols exist for immunizing children with cancer for varicella. Children with AIDS who are only mildly immunosuppressed can be vaccinated.
    • NOTE: Mild illness, low-grade fever, or recent exposure to an infection are not contraindications. Local reactions to previous immunizations or a family history of adverse response are also not contraindications.

The Vaccine Information Statement

  • Determine what information these statements provides

Record Keeping

  • Informed consent
    • What is the reason a nurse must obtained informed consent?
  • Immunization record
  • Vaccine Adverse Event Reporting System
Discharge Teaching
Expected discomforts
  • Low grade fever
  • Local redness & discomfort
  • Local pain
  • Irritability or crankiness
Discharge Teaching
Adverse Effects to report
  • Allergic response
  • High fevers
  • Neurological changes

Passive Immunity

  • Serum titers
  • Knowledge about exposure risks
  • Administration - IV or IM