Mod2: Chemical Basis of Life
Module 2: Chemical Basis of Life
Textbook References
Chapters 2.1-2.3 & 3.1-3.5
Elements: Types of Matter
Atomic Numbers & Symbols:
Carbon (C):
Atomic Number: 6
Atomic Weight: 12.01
Hydrogen (H):
Atomic Number: 1
Atomic Weight: 1.008
Oxygen (O):
Atomic Number: 8
Atomic Weight: 16.00
Nitrogen (N):
Atomic Number: 7
Atomic Weight: 14.01
Phosphorus (P):
Atomic Number: 15
Atomic Weight: 30.97
Sulfur (S):
Atomic Number: 16
Atomic Weight: 32.07
Trace Elements (less than 0.01%): Boron (B), Chromium (Cr), Cobalt (Co), Copper (Cu), Fluorine (F), Iodine (I), Iron (Fe), Manganese (Mn), Molybdenum (Mo), Selenium (Se), Silicon (Si), Tin (Sn), Vanadium (V), Zinc (Zn).
Naturally Occurring Elements in the Human Body (by wet weight)
Element | Percentage |
|---|---|
Oxygen (O) | 65.0% |
Carbon (C) | 18.5% |
Hydrogen (H) | 9.5% |
Nitrogen (N) | 3.3% |
Calcium (Ca) | 1.5% |
Phosphorus (P) | 1.0% |
Potassium (K) | 0.4% |
Sulfur (S) | 0.3% |
Sodium (Na) | 0.2% |
Chlorine (Cl) | 0.2% |
Magnesium (Mg) | 0.1% |
Atomic Structure
Basic Definition
An atom is the simplest unit of an element.
Bohr Model
Niels Bohr's Model of 1913: The atomic nucleus is composed of protons and neutrons, with electrons orbiting around it.
Isotopes
Definition: Atoms with the same number of protons but different numbers of neutrons.
Example: Carbon isotopes (C-12, C-13, C-14).
Half-life of carbon-14: 5,730 years – used for dating dead tissues (fossils).
After 5,730 years, the amount of C-14 is reduced to 50%.
Organisms dead for 5,730 years have 50% less C-14 than living organisms.
The C-14 supply is not replenished in dead tissues.
Radiometric Dating
Carbon-14 Dating:
Living organisms absorb all three isotopes of carbon. After death, C-14 decays to nitrogen-14.
| Years After Death | C-14 Percentage |
|-------------------|-----------------|
| 0 | 100% |
| 5,730 | 50% |
| 11,460 | 25% |
| 17,190 | 12.5% |
Types of Chemical Bonds
Overview
Chemical bonds are physical attractions between atoms due to electron transfer, sharing, or differences in atomic charge.
Atoms form bonds to fill their outermost (valence) shell of electrons.
Types of Bonds
Ionic Bonds:
Formed by the complete transfer of electrons between atoms, resulting in oppositely charged ions that are electrostatically attracted to one another.
Covalent Bonds:
Non-polar Covalent Bonds: Equal sharing of electrons between atoms.
Polar Covalent Bonds: Unequal sharing of electrons, resulting in charged parts of the molecule.
Example: Water (H₂O) is a polar molecule.
Hydrogen Bonds:
Electrostatic attractions between polar molecules (e.g., water).
Macromolecules
Types of Macromolecules
Nucleic Acids: Composed of nucleotides (sugar, phosphate, base).
Proteins: Composed of amino acids.
Carbohydrates: Composed of monosaccharides (short-term and long-term energy storage).
Lipids: Composed primarily of fatty acids (non-polar and insoluble in water).
Amino Acids
Building blocks of proteins, with 20 common amino acids encoded by the human genetic code.
Essential Amino Acids: Obtained from the diet.
Non-Essential Amino Acids: Synthesized in the body.
Each amino acid has a basic structure: amine (amino), carboxyl, hydrogen, α-carbon, and R group.
Protein Structure
Primary Structure: Linear sequence of amino acids linked by covalent peptide bonds.
Secondary Structure: Stabilized by hydrogen bonds, leading to structures like α-helices and β-pleated sheets.
Carbohydrates
Monosaccharides: Examples include glucose, which serves as a short-term energy source.
Disaccharides: Composed of two monosaccharides for short-term energy storage (e.g., lactose).
Polysaccharides: Long-term energy storage (e.g., starch in plants, glycogen in animals) and structural components (e.g., cellulose in plants, chitin in animals).
Lipids
Triglycerides: Composed of three fatty acids; long-term energy storage.
Phospholipids: Form cellular membranes; have hydrophobic fatty acid tails and polar heads.
Steroids: Made of sterol rings; serve as signaling molecules regulating organismal functions.
pH Buffering System
Buffers help maintain pH by absorbing or donating protons (H+).
Example of buffering reaction: CO₂ + H₂O ⇌ H₂CO₃ ⇌ HCO₃⁻ + H⁺.