IMMUNOLOGY AND SEROLOGY WITH BLOOD BANKING

  1. Which of the following immunoglobulins is most efficient at activating complement via the classical pathway?

A. IgG2

B.IgG4

C.IgM

D.IgA

  1. Which of the following structures of an immunoglobulins molecule is involved in the activation of complement pathway?

A.Fc region

B.Fab region

C.Hinge region

D.J chain

  1. Immunoglobulin classes are differentiated according to the molecular structure of

A. Light chains

B. Heavy chains

C. Fab region

D. Fc region

  1. Macrophages and monocytes have Fc receptors for which of the following immunoglobulins?

A.IgA

B.IgD

C.IgG

D.IgM

  1. The membrane attack complex formed during the activation of complement via the classical pathway consists of:

A. C1q, C1r, C1s

B.C3a, C3b, C3d

C.C5a, C5b

D.C5b through C9

  1. Which of the following pairs of immunoglobulins is most efficient at activating complement via the classical pathway?

A.IgG1 and IgG3

B.IgG and IgG4

C.IgG2 and IgG3

D.Ig2 and IgG4

  1. Cells that are precursors of plasma cells and also produce immunoglobulins are:

A. Macrophages

B. B lymphocytes

C. T lymphocytes

D. Monocytes

  1. Which of the following immunoglobulin classes is associated with a secretory component?

A.IgA

B.IgD

C.IgE

D.IgG

  1. Treatment with IgG with papain results in how many fragments from each immunoglobulin molecule?

A.5

B.4

C.3

D.2

  1. The IgM molecule is a:

A. Dimer

B. Trimer

C. Tetramer

D. Pentamer

  1. Which IgG subclass is most efficient at crossing the placenta?

A. IgG1

B. IgG2

C. IgG3

D. IgG4

  1. The J-chain is associated with which of the following immunoglobulins?

A. IgG

B .IgE

C. IgD

D. IgA

  1. The assembly of the complement “membrane attack unit” is initiated with the binding of:

A. C5

B. C4

C. C3

D. C1

  1. Macrophages phagocytosis of bacteria is enhanced by which of the following:

A. Antigen

B. Hapten

C. Opsonin

D. Secretory piece

  1. Which of the following is most likely to activate the alternative pathway of complement activation?

A. Lipopolysaccharides

B. Glycoproteins

C. Haptens

D. IgG complexed with antigen

  1. Which of the following activities is associated with C3b?

A. Opsonization

B. Anaphylaxis

C. Vasoconstriction

D. Chemotaxis