Pharmaceutical Excipients Notes

Pharmaceutical Excipients

Definition

  • Excipients are substances other than the active medicament(s) included in the manufacturing process or contained in the finished pharmaceutical product dosage form.
  • The word "excipient" comes from the Latin "excipere," meaning 'to except' or 'other than'.

Purpose of Excipients

  • Modulating the solubility and bioavailability of active pharmaceutical ingredients.
  • Modulating the immunogenic response of active ingredients.
  • Maintaining the pH and/or osmolality of liquid dosage forms.
  • Improving dosing compliance (by giving shape and improving palatability/elegance).
  • Increasing the stability of the active ingredient, including protection from degradation/denaturation.
  • Preventing aggregation and dissociation of different molecules (e.g., proteins and polysaccharides).
  • Providing bulk to the formulation.
  • Helping active ingredients maintain preferable polymorphic form or conformation.
  • Conferring therapeutic enhancement on the active ingredient (e.g., facilitating drug absorption, reducing viscosity, or enhancing solubility).
  • Aiding in the handling of