Pharmaceutical Excipients Notes
Pharmaceutical Excipients
Definition
- Excipients are substances other than the active medicament(s) included in the manufacturing process or contained in the finished pharmaceutical product dosage form.
- The word "excipient" comes from the Latin "excipere," meaning 'to except' or 'other than'.
Purpose of Excipients
- Modulating the solubility and bioavailability of active pharmaceutical ingredients.
- Modulating the immunogenic response of active ingredients.
- Maintaining the pH and/or osmolality of liquid dosage forms.
- Improving dosing compliance (by giving shape and improving palatability/elegance).
- Increasing the stability of the active ingredient, including protection from degradation/denaturation.
- Preventing aggregation and dissociation of different molecules (e.g., proteins and polysaccharides).
- Providing bulk to the formulation.
- Helping active ingredients maintain preferable polymorphic form or conformation.
- Conferring therapeutic enhancement on the active ingredient (e.g., facilitating drug absorption, reducing viscosity, or enhancing solubility).
- Aiding in the handling of