Drug Interactions with Sulphonylureas

Drug Interactions with Sulphonylureas (MA)

1. Monoamine Oxidase Inhibitors

• Potentiate the activity of sulphonylureas

• Mechanism of potency is unknown

2. Antagonistic Drugs

• Examples (GCGH):

  • Glucocorticosteroids

  • Growth hormone

• Mechanisms:

  • Actions on insulin release

  • Effects on insulin sensitivity