Pathology stroke

Stroke Overview

  • Definition: A stroke, also known as a cerebrovascular accident (CVA), occurs when there's an interruption of blood supply to the brain.
  • Importance: Knowledge of stroke is crucial as it is extremely common and affects a significant number of people annually.

Statistics

  • Frequency:
    • Every 40 seconds a person in the US has a stroke.
    • Every 4 minutes, someone in the US dies from a stroke.
    • Approximately 800,000 people experience a stroke each year in the US.
  • Risk Factors:
    • Risk of stroke doubles for individuals over the age of 55.
    • Higher incidence in men, but women have a higher mortality rate due to different symptom presentation.

Geographic and Lifestyle Correlation

  • Discussion of CDC maps showing correlation between stroke rates and regions with high rates of COPD and heart disease, particularly in the South.
    • Noted that some regions had insufficient data due to lack of reporting.
  • Lifestyle factors contribute to increased risk, including poor access to healthcare.

Types of Strokes

Ischemic Stroke

  • Description:
    • Most common type, accounting for about 85% of strokes.
    • Caused by clots blocking blood supply.
  • Types of Ischemic Strokes:
    • Embolic Stroke: A clot that forms elsewhere (e.g., in the calf) and travels to the brain.
    • Thrombotic Stroke: A clot that forms directly in the brain.
  • Key Term: Ischemia - refers to the interruption of blood supply caused by a clot.

Hemorrhagic Stroke

  • Description:
    • Accounts for about 15% of strokes but are generally more deadly.
    • Occurs when a blood vessel ruptures, often due to an aneurysm.
  • Treatment Challenges:
    • Requires locating and stopping the bleed, making it harder to treat than ischemic strokes.

Terminology of Strokes

  • Complete Stroke: Abrupt onset of neurologic deficits, typically associated with an ischemic stroke.
  • Stroke in Evolution: Symptoms develop slowly over days, often linked with hemorrhagic strokes.
  • Transient Ischemic Attack (TIA): A "mini-stroke" resulting in temporary neurologic deficits that resolve within 24 hours. Indicates a high risk for future strokes.

Risk Factors for Stroke

Modifiable Risk Factors

  • Smoking.
  • High blood pressure.
  • Cardiovascular diseases (e.g., heart disease).
  • Diabetes.
  • Heavy alcohol use.
  • High LDL cholesterol.
  • Illicit drug use.
  • Obesity.

Non-Modifiable Risk Factors

  • Increasing age.
  • Ethnic background (e.g., African Americans at a higher risk).
  • Gender differences in risk until about age 55 due to protective effects of estrogen.
  • Genetics plays a minor role (about 6% of cases).

Warning Signs of Stroke

  • FAST Acronym: Face drooping, Arm weakness, Speech difficulties, Time to call for help.
  • Sudden weakness or numbness, especially on one side of the body.
  • Sudden dizziness or loss of balance.
  • Sudden severe headache (often indicative of a hemorrhagic stroke).
  • Changes in vision.

Treatment Options

Ischemic Strokes

  • TPA (tissue plasminogen activator): A medication administered within three hours post-stroke onset that can dissolve clots.
    • Critical to differentiate between ischemic and hemorrhagic strokes before administration.

Hemorrhagic Strokes

  • Limited treatment options compared to ischemic strokes.
  • Possible surgery to locate and correct the source of the bleeding (e.g., decompressive craniectomy).
  • Diuretics may be used to manage symptoms like high blood pressure.

Patient Presentation Based on Affected Brain Lobes

Frontal Lobe (supplied by ACA and MCA)

  • Controls voluntary movement and higher cognitive functions.
  • Symptoms of a frontal lobe stroke:
    • Impulsive behavior and lack of control.
    • Poor speech control leading to choppy speech patterns (Broca's area for language production found here).

Parietal Lobe (primarily supplied by MCA)

  • Processes sensory information.
  • Symptoms include:
    • Hemispatial neglect: Unawareness of one side of the body.
    • Difficulty in perception and executive functioning (planning and coordination).

Temporal Lobe (supplied by MCA)

  • Involved in auditory processing and language comprehension (Wernicke's area).
  • Symptoms include:
    • Fluent aphasia (difficulty understanding language, producing nonsensical speech).

Occipital Lobe (supplied by PCA)

  • Responsible for visual processing.
  • Symptoms include:
    • Visual deficits such as blurry vision or contralateral homonymous hemianopsia.
  • Difficulty recognizing objects (simultagnosia).

Cerebellar Strokes

  • Affects coordination and balance, leading to ataxia.
  • Symptoms include:
    • Dysmetria: inability to judge distances (overshooting or undershooting).
    • Nausea and vertigo with cerebellar involvement.

Prognosis and Recovery

  • Recovery factors: Patient's preexisting conditions, prompt treatment, rehabilitation, and presence of comorbidities.
  • Most measurable neurologic recovery occurs within three months, with diminished recovery expected after one year.
  • Lower extremity recovery is typically faster than upper extremity recovery due to weight-bearing activities.

Cognitive and Emotional Outcomes

  • Risk of depression linked to frustration and cognitive impairments.

- Emotional responses can become blunted or flat (flat affect).