Micro 1: Classification of Microbes and The Microbiome and Health

LEARNING OUTCOMES

  • Classification of microorganisms: bacteria, viruses, fungi, protozoa, arthropods.

  • Differentiate based on phenotypic and genotypic characteristics.

  • Define microbiome-related terms: colonized, transient, symbiosis.

  • Discuss microbial components of microbiome and its development over time.

  • Associate microorganisms with anatomical sites.

  • Importance of microbiome to health and complications from disruption.

  • Describe restoration methods for disrupted microbiome.

MICROBIOLOGY OVERVIEW

  • Study of microscopic organisms, many not visible to the naked eye.

  • Clinically oriented applied microbiology important for patient management.

  • Microbial-related assessments: infection control, antimicrobial resistance, and emerging pathogens.

MICROBIOME

  • Mixture of organisms in various anatomical sites (skin, mouth, gut).

  • Colonization vs. infection: colonization does not harm the host, infection does.

  • Symbiosis definitions: commensal, mutualistic, parasitic.

CLASSIFICATION OF MICROORGANISMS

  • Bacteria: Single chromosome, no organelles.

  • Fungi & Protozoa: Eukaryotic, contain nuclei and organelles.

  • Viruses: Not cells, obligate intracellular; consist of nucleic acid and protein capsid.

  • Protozoan Types: Ciliated, flagellated, sporozoan, amoeboid, etc.

  • Helminths & Arthropods: Parasitic worms and vectors for infectious agents.

ROLE OF MICROBIOME IN HEALTH

  • Provides nutrients, stimulates immunity, prevents pathogen growth.

  • Disruption leads to risks such as opportunistic infections (e.g., C. difficile).

  • Restoration strategies include fecal microbiota transplantation (FMT).