Psychosis

Dopamine Partial Agonist:

  • Ariprazole

    • Indication: Manage and treat schizophrenia and bipolar disorder, as well as for the treatment of irritability associated with autistic disorder.

    • Pharmaco-kinetics:

      • Absorption: peak plasma concentrations occurring within 3-5hrsafter oral administration, with a bioavailability of approximately 87%. Metabolism involves hepatic pathways, primarily through the CYP2D6 and CYP3A4 enzyme systems.

      • distribution: intravenous administration is high (404L or 4.9L/kg) with a significant volume of distribution in various tissues, indicating extensive tissue binding and potential accumulation in the body.

      • Metabolism: metabolized by 3 bio transformation pathways: dehydrogenation, hydroxylation, and N-dealkylation , each contributing to the formation of several active metabolites that may enhance or prolong the therapeutic effects.

      • excretion:

    • Pharmaco-dynamics:

    • Adverse reactions: Constipation, dry mouth, dizziness, and increased heart rate, which may vary in severity among individuals. Myalgia

    • Nursing Considerations:

  • Brexpiprazole

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

  • Cariprazine

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

Dopamine-serotonin receptor blockers:

  • Chlopromazine

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

  • Pericyazine

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

  • Triflupenthixol

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

  • Flupenthixol deconoate

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

Dopamine Receptor Blockers

  • Haloperidol

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations:

  • Amisulpride

    • Indication

    • Pharmaco-kinetics:

    • Pharmaco-dynamics:

    • Adverse reactions:

    • Nursing Considerations: