Topic 3 - Exercise Physiology and Bioenergetics
ATP(3), ADP(2), AMP(1)
Think of each of these systems like a factory
All three energy systems produce ATP
ATP is not energy, ATP is the storage form of energy. Energy is heat. This heat is measured through calories.
Metabolism
Metabolism: Total of all catabolic and anabolic reactions
Anabolism:
Constructs molecules - legos brought together
Requires energy
Known also as an endergonic process
Energy used/stored
Catabolism:
Breaks down molecules - Break legos apart
Units are oxidized to release energy or used in other anabolic reactions
Energy Systems
All systems work at the same time continously, but what is the primary one being used at certain times?
Highest to lowest concerning intensity:
Phosphogen first
Glycolytic second
Oxidative third
The replenishment of ATP in human skeletal muscle is accomplished by three basic energy systems:
Phosphagen/ATP PCR system
Primary source of ATP for short-term, high-intensity activities (max force and output) but is active at the start of all types of exercise regardless of intensity.
EX: weightlifting, jumping, and the begining of sprinting
Creatine phosphate (CP) is stored in muscles (greater contractions in type II fibers) and is broken down to replenish ATP. And has larger motor units.
Creatine kinase increases rate of synthesis of ATP from ADP and CP
Energy yiels = 1 ATP per 1 CP
Lowest volume created but you get it quick (now)
Provides ATP the fastest
Glycolytic system
When decrease intensity to something that can be held for two minutes, the glycolitic system is teh primary system
Primary source of ATP for high-intesnity activity up to about 2min and takes over for the phosphagen system as duration of activity continues
Any intenisty where you can maintain it up to 2min and can not maintain that intensity longer then 2min
EX: racquetball or running 600-800meters
Glycolysis = breakdown of carbohydrates from blood glucose or muscle glycogen to rplensig ATP and yield pyruvate and H^+
Pyruvate enters either…
Fast glycolysis: if high inetnisty activity is converted to lactate
Slow glycolysis: if moderate intenisty activity it enters the mitochondria (is actually acrobic metabolism)
At the moment at which pyuvate apears is oxygen also present?
If oxyegn is present, that indicates a lower intensity.
If oxygen is not present it converts to lactate and it is fast glycolysis and higher intensity
Stimulated by ADP, AMP, P, ammonia, and a slight decrease in pH
Inhibited by: Markedly lower pH or increased levels of ATP, CP, citrate, and free fatty acids.
Free fatty acids cointains a lot of energy so you don’t need to use Glycolysis
Energy yield = 2ATP per glucose, 3ATP per glycogen
Blood Lactate
Hydrogen accumulation = low pH = more acidic. Lactic acid is converted rapidly into lactate = burning sensation. the burning sensation is just a warning to teh body to let it know it is running out of ATP
Lactate istaken to the liver where it is converted to glucose, and that glucose is either released into the bloodstream or repackaged into glycogen. Then we have more energy to use again
Gluconeogenesis: the creation of new sugar
Gluco = sugar
Neo = new
Genesis = the creation of
Lactate threshold (LT): the point at which the body can no longer use lactate from the bloodstream as quick as it builds up. It’s also known as the anaerobic threshold or aerobic to anaerobic transition point
Onset of blood lactate accumulation (OBLA): second point of inflection on the curve and is the point at which lactate builds up in the blood at a faster rate
Lactate Threshold
Untrained = 50-60% of VO2 max
Trained = 70-80% of VO2 max
Why is lactate threshold used instead of VO2 max? It is not about how much lactate is produced, it is about how much is accumulated (This person’s energy system is trained this way or not - not if someone is fit)
If we can push more lactate to teh right (greater threshold) then we can do more intensity before we hit lactate threshold
Oxidative System
Oxidative System is the recovery system
Primary source of ATP at rest, low-intensity long duration and aerobic activities
EX: walking on a treadmill, water aerobics, yoga class, etc.
Oxidation = uses primarily carbohydrates and/or fats as substrates
At rest, 70% of the ATP produced is derived from fats and 30% from carbohydrates
AT onset of activity, and as intensity increases, tehre is a shift from fats to carbohydrates
During high-intensity aerobic exercise, aklmost 100% of teh energy is derived from carbohydrates
Protein can be used during long-term starvation and ong steady-state bouts (>90min) of exercise
Carbohydrate oxidation = glucose/glycogen oxidation where pyruvate is transported into mitochondria and is converted to cetyl-CoA
Fat oxidation = triglycerides stored in fat cells are broken down and released as free fatty acids (FFAs) into the blood stream to reach miuscles and mitochondria
Beta oxidatiobn = FFAs broken down to form acetyl-CoA and H+.
H+ carried by NAD and FADH to the electron transport chain
Protien oxidation = protein, primarily branched-chain aminok acids, can be converted to various substrates to replenish ATP
Nitrogen, a waste of amino acids breakdown, eliminated through urea or ammonia
When pyvate neters teh mitochondria it is converted to Acetyl-CoA
Acetyl Co-A eneters Krebs cycle for further ATP production
When NADH or FADH2 eneters the mitochondria it then enetrs teh electron transport chain (ETC)
Electron Transport Chain (ETC)
Oxidative phosphorylation priduces ATP from ADP, NADH and FADH2 molecules
Concentration gradient or protons provides energy for ATP production
Oxygen final acceptor created water
1 NADH = 3 ATP
1 FADH2 - 2 ATP
Oxidative Energy Yield
Slow Glycolysis is anarobic and the ATP yield is 10 and when it goes through REB cycle it goes to 40 fatty acids which are really high in ATP
All three Eneregy Systems
All three energy systems are active at a given time… the extent to which each is used depends primarily on the intensity of the activity and secondarily on its duration
Effect of Event Duration on Primary Eneregy System Used
Duration of event | Intensity of event | Primary energy system (s) |
0 to 6 s | Very intense | Phosphagen |
6 to 30 s | Intense | Phosphagen and fast glycolysis |
30 s to 2 min | Heavy | Fast glycolysis (This one is the best to train lactate threshold) |
2 to 3 min | Moderate | Fast glycolysis and oxidative system |
>3 min | Light | Oxidative system (This one is teh best to train VO2 max) |
Using Interval Training to Train Specific Eneregy Systems
% of maximum power | Primary System stressed | Typical exercise time | Range of work-to-rest period ratios |
90-100 | Phosphagen | 5-10 s | 1:12 to 1:20 (for every second on, 12-20sec off) |
75-90 | Fast glycolysis | 15-30 s | 1:3 to 1:5 |
30-75 | Fast glycolysis and oxidative | 1-3min | 1:3 to 1:4 |
20-30 | Oxidative | >3min | 1:1 to 1:3 |
Training the Phosphagen System
Deplete because of high-intensity exercise
Creatine phosphate decreases about 50-70% during first 5-30 seconds
ATP decreases no more than about 60%
Resynthesis
Complete resynthesis of ATP within 3-5 min
Complete resynthesis of creatine phosphate within 8 min
Can supplement to increase repletion
Training the Glycolytic System
Limited stores of glycogen: about 500g
Muscle = more important source for moderate- and high-intensity exercise
vs.
Liver = more important during low-intensity exercise
Depletion is a limited factor to exercise and is directly related to fatigue. Carbohydrates are preferred fuel at intensities about 60% to 75% of VO2max
Resythesis is related to postexercise carbohydrate ingestion…
Most rapid in the first 5-6 hours but may take up to 24 hours for complete resynthesis
Training the Oxydative System
Oxygen Consumption: Measure of a person’s ability to take in and use oxygen
At the start of all exercise, we have an oxygen deficit when some energy supplied by anaerobic mechanism
Oxygen deficit: a temorary shortage of oxygen that occurs when the body needs nmore oxygen than it can breathe in
After exercise we have an oxygen debt or excess post oxygen consumption (EPOC) as the body is being restored to pre-exercise levels and uptake remains above resting levels
EPOC: the increase oxygen uptake your body needs after intesne exercise to restore itself to a resting state
Oxygen Uptake
Oxygen deficit is determined by amount of anarobic energy system involved (phosphogen and glycolgic system)
Steady state: you can hold an intenisty continuosly for multiple minutes or greater without significant heart rate variability
EPOC is determined by the amount of oxygen deficit
For a steady state actiovity, the anaerobic demand is minimal, tehrfore teh EPPC is minimal
vs.
There is a high anaerobic demand, therefore the EPOC is large
VO2max: the highest intenisty where your oxydative system is primary
Exercise Physiology
Exercise Physiology: studes how the body repsonds to phyisical activity and adapts to exercise over time
Terminology
Response
Acute stress changes
Something has a rapid onset and a relatively short duration
Deal with a single bout of physical activity and/or exercises
Can occur during or immediatley after
Adaptation
Chronic stress chnages
Something that has slower onset and a relatively long duration
Deal with repeated training/a program and persists over time
Responses and Adaptations to Resistance Training
Factors Influencing Responses/adaptations
Age
Over time our body loses its ability to produce force and generate movement rapidly
This can be reversed or manipulated by high-intensity resistance training
Age-related muscle and bone mass loss
Osteoporosis
Adipokines: are protiens secreated by fat cells.
There are two types:
Antiflamatory
Proinflamatory
Obese individuals have an adipokines imbalance. Specifically ther are too many axcess proinflamatory adipokines and not enought antiflamatory asipokines. This leads to a constant state of low grade inflamation. When this is the case, the bones start to break down
Females are at greater risk because there during menopause there is a decrease in estrogen production. And etrogenis a producer of testosterone, which is anabolic, a builder. When there is a drop in a builder, that can result in low bone mineral density.
vs.
Sarcopenia
Myokines
When we exercise and muscle train, we release myokines and prevent muscle loss
Myokines are released by muscle tissue after a muscle contraction
When a person is seditary, their body is not producing as many myokines
Myokines contribute to maintaining muscle protein
Sarcopenia is age related muscle atrophy. The myokines, when released by muscle contracction, walk around and keep the muscle in place, it prevents muscle loss.
Sex
Differences in strength gains, muscle mass, and acute hormone levels
Relative strength = similar
Accounts for body weight
Absolute strength = greater in males
Most prevalent in upper body
Fat mass and fat free mass percentages
Essential fat for males: 2-5
Essential fat for females: 10-13
Pre puberty
Boys - lower percentage of body fat than girls of similar age, ht, wt
During puberty
Boys - percent Fat mass decreases as fat free mass increases
Boys - Fat mass becomes more central (central adiposity)
Guirls - fat mass increases
Post puberty
Absolute Fat mass increases for both
Genetics
Body “fatness” or even certain behaviors has been largely attributed to genetics
Individual genetic potential when gaining muscle mass, increasing strength, or losing fat is largely dictated by light differences in genetic code, or gene variants
Specifity
The ability of the body to make adaptations that uniquely enhance performance in activity that are most like the exercise stressor
EX: distance running has little to no positive effect on bench press performance
Important notes:
Training mode, velocity of movement, and even typoes of contractions (muscle actions) are also highly specific.
Acute Responses to Resistance Training
Neurological
Small muscles typically depend more meavily on firing rate (speed of motor unit recruitment) to control force output, while large muscles tend to depend more meavily on recruitment (increase in the total number or volume of motor units reqruiting)
Causes of fatigue
Motor unit recruitment increases to compensate for the loss in force production capability of the previously activated motor units
Each time we activate a motor unit, it becomes tired
Motor units that are firing a low rates at the satrt of teh set may have to fire at higher rates (rate coding).
If we fire it more times per minute it becomes more fatiggue
Motor unit recruitment based on the Size Principle
Lower-threshold motor units are typically activated during tasks that do not demand a high amount of force output
EX: maintenance of posture or walking
As demand for force output increases, low-threshold and high-trheshold motor units are simultaneously recruited to meet this demand
Muscular
Accumulation of metabolites
EX: lactate, H+, Pi, ammonia
Hydrogen ions interfere with crossbridge formation. The more free Hydrogen ions, we have less force we are able to produce
Depletion of fuel substrates
EX: creatine phosphate and glycogen
What is the difference between lactate and lactic acid?
Lactate: colroless, odorless organic acid that is a byproduct of cellular metabolism
Lactic Acid: an organic acid produced in teh body during muscle metabolism
Endocrine
Initial phases of training (3-4 weeks) show relatively equal synthesis and breakdown rates of msucle protein
Later phases of training show increased net protein balance = elevation of muscle protein synthesis rates
Increased blood concentrations of hormones
Hormones response is dependent on charcateristics of training sessions
Greater repsonse with higher volume and shorter rest as well as large muscle mass exercises
Maximum growth - maximum hypertrophy response - force the body to produce more - lots of sets with minimal rest
Acute Responses to One Bout of Resistance Exercise
Need to be able to explain why each of these Acute repsonses make sense
NEUROLOGICAL RESPONSE
Variable | Acute Response |
EMG amplitude | Increase |
Number of motor units recruited | Increase |
MUSCULAR CHANGES
Variable | Acute Response |
Hydrogen ion concentration | Increase |
Inorganic phosphate concentration | Increase |
Ammonia levels | Increase |
ATP concentration | No change or slight decrease |
CP concentration | Decrease |
Glycogen concentration | Decrease |
ENDOCRINE CHANGES
Variable | Acute Response |
Epinephrine concentration | Increase |
Cortisol concentration | Increase |
Testosterone concentration | Increase |
Growth hormone cocnentration | Increase |
Chronic Adaptations to Resistance Training
Neurological
In the first 1-2 months of a program, there is…
Improved form and technique
Increased:
Motor unit recruitment
Motor unit firing rate
Motor unit synchronication
Decreased:
Cocontraction/coactivation of muscles
Changes in motor neuron excitability
Advanced Training revers to days that are pure strength training, power training, or advance hypertrophy training
Muscular
Increased Hypertrophy
Greater in Type II fibers compared to Type I
Increase in number of myofibrils (actin and mysosin) within a muscle fiber as well as cytoskeletal and structural proteins
Fiber subtype shift
Type IIx to Type IIa
Endocrine/Metabolic
Minimal evidence of changes in resting hormone concentrations
Increase magnitude of acute response
Increase sensiticity of tissues to hormone release
Decrrease mitochondrial density yet no change to number of mitochondria (not a chnage in number of mitochindria, it menas density)
Muscoskeletal
Bone mineral density affected by strain magnitude an strain rate
Potential decreased risk for osteoporosis
Tendons adapt to loads applied during training
Tendon gets stronger
Possible increased cross-sectional areas and changes in mechanical properties
Little data on ligamentous changes
Not enough evidence on ligaments - not enough blood flow
Training is effective treatment of osteoarthritis, but effects on cartilage are inconclusive
Cardiorespiratory
Aerobic fitness adaptations are likelt dependent on age and pre-existing fitness levels
No negative effects on development of maximal oxygen consumption
Can arguent aerobic endurance eprformance by increasing strength and power
Body Composition
Increased fat free mass and may decrease fat mass over time
Progressive Overload
Overtraining: condition in which an individual trains excessively, causing generalized fatigue and is marked by decreased performance
Types:
Overuse injury or muscle (joint and muscle specific)
Overtraining of the body (whole body is fatigued)
Results from increasing teh volume of teh program at too rapid a pace or maintaining too manyd ays of high intensity without varying load or taking a rest
Symptoms of overtraining from resistance exercise:
Plateau following by decrease of strength gains
Sleep disturbances
Decrease in lean bodyh mass (when not dieting)
Deacrease appetite
A cold taht just will not go away
Persistent flue-like symptoms
Loss of infterest in the training program
Mood changes
Excessive muscle sorness
Detraining: physioplogica; and performace adaptations tat occur when anindivdual ceases an ecxercise training program
Atrophy = loss of muscle mass
Sarcopenia: age related atrophy and can result in a loss of muscle fibers
Non-age related atrophy: due to a decrease in cross sectional area (the diameter) without the loss of muscle fibers
Changes to neurological function
Decreased recruitment, rate coding
Increase contraction
Why do we have a increase in co-contraction with detraining? Because the body is trying to provide for stability. The agonist decreases the amount of force it can produce and as a result we have an increase in co-contraction to make up for the loss of agonist force. The co-contraction provides an increase in stability.
Responses and Adaptations to Cardiovascular Fitness
The effects of aerobic exercise are regulated by the intenisty duration, and frequency of the activity
Intensity - primary determinant
To determine which energy system is primary, secondary, and tertiary - it depends on the intensity of the exercise - all three energy systems will eb present at some point, it is justg a factor of which one is more prominent and used?
Cardiovascular Fitness
Cardiovascular exercises: activities taht involve large muscles and challenge heart and lungs to work hearder
Aerobic Training
The measure for max aerobic capacity is VO2max
Factors Influencing Reposnses/Adaptations
Influence of Age on Changes
VO2max increases as children mature with highest values reached between
12-15 years of age for females
17-21 years of age for males
Values plateau and then decrease with aging
Decline can be negated with training
As we age, if we decrease our muscle mass, that results in a decrease in mitochondria
Why does this drop in mitochondria decrease breathing efficiency? Because when we take in a breath of air, the amount we can use as oxygenation depends on the amount of mitochondria we have. We use mitochondria to convert glucose and sugar to ATP with oxygen. And teh amount of O2 we can take is is dependant on the amount of mitochndria we have So if we have less mitochondria than that oxygen taht we breathe in to use to convert things to ATP. So O2 is wasted.
Influence on Biological Sex on Changes
Physiological changes similar for males and females
Absolute values differ due to body differences:
Females have less muscle mass, smaller heart and lungs, and smaller blood volume than males
Influence of Genetics on Changes
Individuals are born with a theoretical ceiling of human performance, a range that is dependent on training stimulus and motivation
Genetic factors account for about 20-30% of VO2max differences and abou 50% differences in max HR.
Influence of Specifity on Changes
The ability of the body to make adaptations that uniquely enhance performance in activities that are most likely teh exercise stressor.
EX: adaptations are specific to the type of exercise - running, swimming, cycling etc.
Cardiovascular: Acute Responses
NEED TO BE ABLE TO EXPLAIN EACH OF THESE:
Cardiac output (Q) increase
Heart rate (HR) increases
Stroke volume (SV) increases
Blood pressure (BP)
Systolic increases
Diastolic - no change or slight decrease
Mean arterial pressure increases
Excitation of the heart
Sympathetic increases
Parasympathetic decreases
Total peripheral resitance decreases: The rersistance in the circulatory system that is used to create blood pressure
Blood plasma volume decrease
Hematocrit increases - Hematocrit us the percent of red blood cells in the blood
Respiratory Acute Responses
Pulmonary minute ventilation increases
MV = tidal volume (ml) x breathing rate (bpm)
Respiratory exchange ratio (RER) increases
RER teh ratio of carbon dioxide (CO2) produced to oxygen (O2) consumed
Measures the proportion of fat, carbohydrate, and protien used during aerobic processes
Higher RER - mostly carbs
When you have an increase in the number of carbs that are burned, this increases teh amount of CO2 that is expelled, and that is the reason why the numbers change
Low RER - mostly fats
Metabolic/Endocrine: Acute Responses
Metabolism increases = increase CO2, increase lactate, decrease blood pH
Endocrine
Glucagen secretion increases
Glucagon stimulates glucose release
Insulin secretion decreases
Cortisol
Cortisol is repsonsable for uptake of repair components which results in synthesis of tissue post stress
Low-intensity exercise - Cortisol decreases
Moderate- to high-intensity exercise - Cortisol increases
Flight or fight responses is the Phosphagen system - quick energy
Growth hormone increases
Catecholamines increases
Epinephrine and norepinephrine
Chronic Responses to Cardiovascular Fitness
Cardiovascular Chronic Adaptations
Cardio = oxidative system
VO2max increases - increase of number and size of mitochondria
At rest/submaximal intenisty
HR (within 2-20 weeks) decreases - there is a increae in perasympathetic tone which is in the body getting better and activating its calming response
Stroke Volume increases
< 10 mmHg changes in Blood Pressure
Long-term aerobic exercise
Cardiac hypertrophy increases
Left ventricle and myocardial wall thickness
Red blood cell volume increases
Capillary density increases
Respiartory Chronic Adaptations
Improved efficiency
Decreased energy cost per breath = more oxygen to muscles
With increase in mitochondria tehy don’t need to grasp for breath
When an oxidative energy system is untrained it is because tehy don’t have enough mitochondria in their muscles so they have to suck in a bunch of air
Less fatigue of diaphram/breathing muscles - they are more trained
Exercise Types:
NEED TO KNOW THE DIFFERENCE BETWEEN SUBMAXIMAL AND MAX INTENSITY
Why is it that submaximal intensity tidal volume frequency decreases but at maximal intensity it increases? Because less air is needed to do the same amount of work. In shape vs. out of shape - because of the number of mitochondria - not trained
Submaximal intensity: minute ventilation decrease - we have a drop because less air is needed to do the same aount of work
Tidal volume increases
Tidal Volume: the amount of air that moves in and out of the lungs per breath
Frequency decreases
Maximal intensity: MV increases
Tidal volume increases
Frequency increases
Metabolic/Endocrine: Chronic Adaptations
Increased energy efficiency: leads to greater capacity to perform at higher exercise intensities for prolonged periods
Increased:
Reliance on fat as energy
Lactate threshold
VO2max of 10-30%
Why is it that a increase in VO2 max will also lead to a increase in lactate threshold? Beacuse we are now able to run faster and longer relying more on the oxydative system instead of other systems which help us increase our lacate threshold
Endocrine
Enhanced insulin sensitivity
Musculoskeletal: Chronic Adaptations
Why is it that chronic cardiorespiratory training results in an increase in muscle glycogen?
Relation to performance…
Capillary desnity increases
Mitochondrial density/size increases
Activity of oxidative enzymes increases
Intramuscular glycogen stores increases
If we imporve our oxidative capacity we are able to store more glycogen because we are not using as much
Myoglobin stores increases
Tendon/ligamants/capilage appears to remodel with mechanical stress
Most consistant evidence of hypertrophy is tendons.
Tissues will remodel according to mecanical stress.
Moderate to high bone-loading forces (jogging, jumping, etc.)
Maximize bone mass in early years
Hypothesis of Pech bone mass
Maintain bone mineral content through middle age
Combat bone mineral loss in older age
Other Chronic Adaptations
Body composition adaptations
Weight loss more likely to occur with moderate-intesnity cativity activity of >150 min per week
Minimal effect on fat free mass
Overtraining in Cardiovascular Fitness
Overreaching can occur with short-term training…
Recovery can occur within a few days or up to two weeks with appropriate intervention
Decrement in performance occurs followed by enhanced performance as compared to baseline
Overtraining occurs when adaptation capacity is exceeded without sufficient recovery…
More serious and results from untreated overreaching
Long-term impaiments in perfromance as well as other conditions
Signs of Cardiovascular Overtraining:
Unusual Muscle Soreness
Performance Plateaus
Chronic Fatige
Increased Resting Heart rate or Blood Pressure
Overuse Injuries
reproductive Issues
Unintentional Weight loss
Recurrent Illnesses
Decline in Motivation or Joy
Difficulty Sleeping
Overtraining Subtypes
Parasympathetic Dominant: Trouble firing up
caused by excessive volume and is found when aerobic endurance overtarining occurs
Sympathetic Dominant: Trouble calming down
Primarily teh result of high-intesnity overload and found with anerobic or resistance overtraining
Detraining of Cardiovascular Fitness
WHY DO EACH OF THESE THINGS HAPPEN?
Two weeks after training is stopped…
Muscular endurance decreases
VO2max and cardiac output decreases
Aerobic enxyme levels decreases
Four weeks after training is stopped…
Muscle’s respiratory ability decreases
Glycogen levels decreases
Because the body is not as efficent to the porycycle and tehrfore less able to store muscle glycogen
Lactate production increases
If you stop training the oxidative system that increases lactate threshold which means lactate will spike at a lower intensity