Major Depressive Disorder

Clinical features
- One or more major depressive episodes separated by periods of remission
- Single episode – highly unusual
- Recurrent episodes – more common

At least one major depressive episode.
The occurrence of the major depressive episode is not better explained by:
- schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other specified and unspecified schizophrenia spectrum and other psychotic disorders.
There has never been a manic episode or hypomanic episode.
- Note: This exclusion does not apply if all of the manic-like or hypomanic-like episodes are substance induced or are attributable to the direct physiological effects of another medical condition.
Specify the clinical status and/or features of the current or most recent major depressive episode:
- Single episode or recurrent episode
- Mild, moderate, severe
- With anxious distress
- With mixed features
- With melancholic features
- With atypical features
- With mood-incongruent psychotic features
- With mood-congruent psychotic features
- With catatonia
- With peripartum onset
- With seasonal pattern (recurrent episode only)
- In partial remission
- In full remission