Krebs cycle

Series of enzyme-controlled reactions

In the matrix of the mitochondria

Acetyl CoA enters circular pathway from link reaction

4 carbon oxaloacetate accepts the 2 acetyl fragment from acetyl CoA to from citrate, releasing CoA

Citrate converted back into oxaloacetate via a series of intermediates

• Decarboxylation of citrate, releasing 2CO₂ as waste gas

• Dehydrogenation of citrate, releasing H atoms that reduce coenzymes NAD and FAD

• Substrate level phosphorylation is transferred from one of the intermediates to ADP, forming 1 ATP

Each glucose molecule causes the cycle to turn twice so per glucose we produce 4CO₂, 4NADH, 2FADH and 2ATP molecules