Pharmacokinetics

Pharmacodynamics

What drugs do to the body therapeutic effects side effects preferably mechanism of action

Pharmacokinetics

What the body does to drugs: absorption, distribution, metabolism, excretion. The effect of a drug is dependent on its concentration at an active site

metabolism of drugs is conversion of inactive form of medication to an active form

ADME

Absorption from the site of administration

Distribution from the site of administration

Metabolism

Excretion

Absorption

routes of administration

  • oral

  • sublingual

  • rectal

  • inhalation

  • epithelial

  • injection

considerations include: speed of effect, convenience, degradation, localisation

movement of drug fro where it was to the circulation

what is first pass metabolism?

Distribution

How blood moves from areas to different parts of the body between blood & tissue. Main influencing factors:

  • blood flow

  • protein binding

  • drug lipophilicity

  • compartmentalisation

absorption of blood (ocassionall lymph & csf)

drug molecules move around bbod is 2 ways:

  1. bulk flow - blood stream, lymph, cerebrospinal fluid

  2. diffusion - molecule to molecule, over short distances

diffusion to & from aqueous transport dependent on crossing cell membranes - drug weight, lipoplasticity, carrier proteins

can veiw body

Calculations:

CLren=Cu x Vu/Cp - renal clearance