Introduction to Integumentary System
The integumentary system includes the skin and its appendages which separate the inside of the body from the outside environment.
The skin plays a vital role in maintaining homeostasis by regulating body temperature, sodium levels, and oxygen concentrations.
Function of the Skin
Acts as a barrier to separate internal body processes from the external environment, ensuring different temperatures and chemical levels are maintained within the body.
Helps in regulating body temperature and maintaining other homeostatic functions.
Layers of the Skin
Epidermis: The outermost layer composed of stratified squamous epithelium, which protects against environmental damage.
Dermis: Lies beneath the epidermis, made of connective tissue and containing blood vessels, nerves, and glands.
Hypodermis (Subcutaneous Layer): Not part of the cutaneous membrane but serves as insulation and fat storage.
Key Cell Types
Keratinocytes: The predominant type of cell which produces keratin— a water-resistant protein crucial for skin barrier function.
Melanocytes: Responsible for producing melanin; aids in protecting against UV radiation.
Dendritic (Langerhans) Cells: Part of the immune system; these cells 'eat' pathogens.
Tactile (Merkel) Cells: Sensory receptors that contribute to the sense of touch.
Layer Breakdown
Stratum Basale: The deepest layer that undergoes continuous division to replenish skin cells.
Stratum Granulosum: Cells here are further away from nutrients in the dermis. This layer helps with keratin formation.
Stratum Corneum: The outermost dead layer of cells; provides protection and aids in moisture retention.
Thick Skin vs. Thin Skin
Thick Skin: Found in the palms and soles; contains more sweat glands and lacks hair follicles and oil glands.
Thin Skin: Covers most of the body; contains hair follicles and oil glands.
Keratin Function
Protects skin from water loss and environmental damage.
Melanin Role
Provides skin color and offers protection against UV radiation; more melanin is produced upon sun exposure to protect DNA from damage.
Types of Skin Cancer
Basal Cell Carcinoma: Common but less aggressive, originates from keratinocytes primarily in sun-exposed areas.
Squamous Cell Carcinoma: More aggressive than basal cell but less critical if caught early.
Melanoma: The most dangerous form of skin cancer; can metastasize quickly. Symptoms include changes in mole size or color.
Cleavage Lines: These lines in the dermis indicate the orientation of collagen fibers; incisions made along these lines heal better.
Reticular Layer: Deep layer containing dense connective tissue; houses most of the skin’s sensory receptors and structures like sweat glands, oil glands, and hair follicles.
Receptors
Nociceptors: Pain receptors.
Mechanoreceptors: Detect pressure and touch, located throughout the dermis.
Importance: Skin receptors allow the body to sense environmental conditions and react accordingly, thereby playing a role in homeostasis.