Molecular genetics

DNA - the code of life

Historically Nucleic acid was ignored due to… - the monotonous nature of the molecule

Components of Nucleic acid- composed of acids and proteins

Proteins were believed…- to be the code due to its diverse nature ( 20 diff. amino acids)

Who is Friedrich Miescher? in the 1860s, He discovered nonprotein substances ; “nuclein”

Who is Joachin Hammerling? In the 1930s, this scientist hypothesized that hereditary info is stored in the nucleus.

Who is Griffith? -In the 1920s he was trying to develop vaccine for pneumonia, which lead to scientist to suspect that protein is not hereditary

Who is Chargaff? this scientist created data that confirms Watson and cricks findings

What is Chargaff’s data ? - nucleotide base compositions of the DNA from various organisms

Linus Pauling was studying DNA structure in California ( competing scientist against Watson and crick)

What Watson and Crick use to solve the structure of DNA? -”tinker toys” and X-ray crystallography of Rosalind Franklin

What did Watson and Crick deduce about DNA (Watson-crick Model) ? - Helical shape, uniform width (2nm), bases stacked 0.34 nm apart

2 stands of DNA consists of (Watson-crick model) ? - sugar phosphate backbones joined by nucleotide bases ( A and T) (G and C)

What are antiparallel strands ? - 5’ to 3’ one strand , 3’to5’ other strand

What did Watson and crick also suggest? - the mechanism of DNA replication “ semi-conservative model”