the lazarus effect

• documentary seems biased - pepfar wasn’t as great as it portrays

pepfar - january 2003, $15 billion (compassionate conservatism)

• in june - iraq → WMD (neo conservatism)

• marketing - they were doing a benevolent thing by giving them expensive medicine at no cost

  • goal - provide ART access to those who can’t afford it

  • moral obligation

    • who was in congress at the time to pass?

• blueprint - marshall plan: use U.S. resources to rebuild after WWII

• once you start, you have to keep taking it at the right time on the dot

  • if you take away ART, the HIV replicates

CD4+ T cell count bs HIV load

• monitoring CD4+T cell count allows one to track progression towads full-blown AIDS

  • healthy person - 500-1500 cells mm-1

  • when CD4 cell count falls <200 cells mm-1, person diagnosed with full blown AIDS

Immune System

• innate

  • non specific/no memory

  • always on

• adaptive

  • specific

  • memory function

  • usually off

T helper Cells

Acute Phase of HIV - peak of viral load early on

Kaposi’s Sarcoma - not common (naturally-occurring)

PrEP - pre-exposure prophylaxis

• prophylaxis - drug can be taken as a preventative

prevention

• education

• contraception

• PrEP

b) donor has advantage - can control situation, get recipient to do things

e) pepfar failed to look at sustainable goals, funders for pepfar were against the making of generic versions of pepfar so countries can make their own

co-infection - very common in HIV/AIDS, destroys immune system

Hepatitis C - liver

Tuberculosis