BREAST CYTOLOGY

BREAST CYTOLOGY

Normal Breast Anatomy

  • Components of the Normal Breast:
    • Suspensory Ligaments: Connective tissue that supports breast structure.
    • Fat Lobules: Adipose tissue providing cushioning.
    • Lactiferous Sinus: Storage area for milk before it exits the nipple.
    • Areola: Pigmented area surrounding the nipple, containing glands.
    • Nipple: The protruding outlet for milk delivery.
    • Lactiferous Duct: The duct through which milk travels from lobules to the nipple.
    • Alveolus: Glandular structure where milk is produced.
    • Retromammary Space: Area behind the breast, allowing for mobility.
    • Pectoralis Minor and Pectoralis Major: Chest muscles beneath the breast.
    • Intercostal Space: Space between the ribs providing support and vascular supply.

Breast Cells

FNA (Fine Needle Aspiration) from Normal Tissue

  • When performing FNA on normal adult breast tissue, the following can be expected:
    • Ductal Epithelial Cells: These cells are generally derived from ductal structures and can form small cohesive groups.
    • Small Stromal Fragments: Connective tissue components present in FNA samples.
    • Fatty Tissue: Adipose material found during aspiration.

— Ductal Components:

  • Lactiferous Duct: Main duct to the nipple
  • Segmental Duct: Branches leading from lactiferous ducts.

Myoepithelial and Milk-Secreting Cells

  • Myoepithelial Cells: Positioned between the basal lamina and epithelial cells; help in expelling milk.
  • Milk Secreting Epithelial Cells: Responsible for milk synthesis during lactation.

Nipple and Lactation

Changes During Pregnancy

  • **Cellular