Rat strains and characteristics

Inbred strains Usefulness as models

ACI: Congenital genitourinary anomalies, prostatic adenocarcinomas

BB/Wor: Juvenile insulin-dependent diabetes mellitus

BN (Brown Norway): Inducible, transplantable myeloid leukemia, hydronephrosis, bladder carcinoma

BUF (Buffalo): Spontaneous autoimmune thyroiditis, host for transplantable Morris hepatoma

COP (Copenhagen): Prostate adenocarcinoma

F-344 (Fischer 344): Inbred rat model for National Toxicology Program’s Carcinogen Bioassay Program and the National Institute on Aging

LEW (Lewis): Multiple sclerosis, various experimentally induced autoimmune diseases

LOU/C: Myeloma, production of IgG autoantibody SHR (spontaneous hypertensive rat) Hypertension, cardiovascular research

WF (Wistar-Furth): Mononuclear cell leukemia

Zucker: Obesity

Brattleboro: Diabetes insipidus (autosomal recessive)

Gunn: Jaundice, kernicterus (autosomal recessive)

Nude: T cell deficient (autosomal recessive)

Obese SHR: Type 4 hyperlipoproteinemia (autosomal recessive)