Innate Immune system 

  • what is the non immune defense?
    • physical and biological barriers
    • skin dead skin→ physical
    • bacteria on the skin make it more difficult for pathogens to enter
    • ciliar in airways ti keep pathogens out
    • diarrhea
    • vomiting
    • sneezing
    • coughing
  • what is couqing and how is it triggered?
    • stimulation of mechanosensitive receptors in bronchi -→ nevus vagus → medulla oblongata -→
  • what is the venturi effect?
    • the borrower the pathway gets the where eth air gos through therefore the air flow is stronger
  • What are the most important cells in the innate immune system?
    • monocytes( pre-form) → macrophages
    • and granulocytes:
    • neutrophils
    • basophils
    • NK
    • innate lymphoid cell
    • conventional dendritic cel
    • plasmacytoid dendritic cell
    • (epithelial cells )
    • (stromal cells)
    • ( endothelial cell)
  • what does memory and specific have to due with inate immune system
    • it is specific and has memory however less then in auqired
  • .
    • cell get injured -→ cells die du to neecrios → DAMSs(danger proetins) enter extracellular space → proteins are ligand for reecpetrs on macrophages(
  • how do macromages recognize bacteria?
    • PRRs detect PAMPs
    • trigers: phagocytosis
  • signaling for inflmation
    • production of cytokines: pps are trigger by DAMPS -→ toll like recepties trigger nucles which makes proteins for inflammasome -→ inflamosn finishes producing IL-1beta which is a cytokine