Behavioral Neuro (fixed)
Structure of the Vertebrate Nervous System
Neuro anatomy is the sutydy of the structure or organization of the nervous system
This field of study largely relies on a localizationist approach
Neuroanatomy contains differenet levels of analysis from gross to cellular level
Important Terminology
Rostral-> towards
Caudal-> away
Pereipheral nervous system- somatic and autonomic nervous system
CNS- brain and spinal cord
PNS is everyhting but the brain and spinal cord
Divisions of the NS
Somatic
Contains all axons conveying messages from the skin or beneath the skin, tactile info, pain signals
Motor neurons
Axons that project out to the muscles
Autonomic
Maintaining homeostasis
Heart rate
Blood pressure
Connects to alot of cognitize and emotional process but communicates with brain mostly
Diff arangement of neurons that give us idea of how the system works
Divided into 2 seperate system
Parasympathetic
Maintanence of body while resting
Long preganglionic acid
Ganglia sit near or within the arget organs so the preganglionic axons are long and post ganglionic axons re short
acetylcholine
Sympathetic
Fight or flight system
norepinephrine
Ganglion
Cluster of neurons in the PNS
Central Nervous System
Spinal cord
Dorsal root ganglion
Brings sensory info
Into the cns via dorsal horn
Butterfly is the grey matter
a butterfly- or "H"-shaped inner region made of nerve cell bodies, unmyelinated axons, dendrites, and glial cells
Everythng else is white matter
the outer tissue layer composed of myelinated nerve fiber bundles (tracts) that relay sensory and motor signals between the body and the brain
Sensory comes in through Dorsal side
Motor comes out through ventral side
Ganglion
Bunches of neruonal cell bodies all together outside the CNS
Call GANGLION NUCLEUS IN CNS
Segmentation
Each section of the spinal cord sends signals toi a specific part of your body
Lower back to legs
Dr shenai patients
Mid chest to mid back and so on and so forth
More terms
Central canal
A fluid filled channel of the spinal cord
Ventricles
Are four fluid filled cagaties within the brain containing cerebrospinal fluid
CSF
Clear fluid in the brain and spinal cord
Provides cushioning for the brain
Also is a resevoir of hormones and nutrition for the brain+ spinal cord
Meninges
Membranes that surround the brain and spinal cord
Dura Mater
Drua mater outermost thick skin like later
Thick
Gross
Super difficult to cut through
Arachnoid Space
Contains blood cells and CSF
Pia Mater
Innermost thinner layer
Right on top of brain
Super thin
PAD
P
Pia Mater
A
Arachnoid Space
D
Dura Mater
Major Divisions of the Brain
Three Major
Forebrain
Diencephalon
Hypothalamus
Small area near the base of the forebrain
Converys messages to the pituatary gladn to control endocrine function
Also has neural projections to many brain regions
Motivated behaviors eating drinking reproduction defensive etc
Pituitary gland
Hormone producing gland found at the base of and controleld by the hypothalamus
Thalamus
Serves as a intermdiary between sonsorimotor cortex
We often refer to the thalamus as a relay betweeen cortex and subcortical systems but a lot of evidence shows that t is a key structure in information processing
Telencephalon
Basal Ganglia
Comprised of caudate nucleus
Putamen
Globus pallidus
Associated with voluntary movement procedual learning
Loss of function of basal ganglia is what we see with PD
Procedural learning
Limbic System
Most of the limbic system is contained within the telencephalon except the hypothalamus
Comes from latin term meaning border
Everything that makes up the limbic system are on the border of stuff
Olfactory bulb
Hippocampus
Amygdala
Hypothalamus kinda
Cingulate gyrus of the cerrebral cortex
Really important for emotion and motivation and long term memory
Midbrain
Mesencephalon
Compared ot other parts of the brain the midbrain is quite small
Superior and inferior Collicullus (2 for each side of the brain)-
Appear as bumps
On the top suface of the midbrain
The colliculi are important for orienting to visual and auditory stimuli
Together they are talked about as tectum
Hindbrain
MEdulla
Brain stem
Located superior to spinal cord
Responsible for vital reflexes such as breathing
Hreart rate
Vomitiing
Salivation
Coughing
Sneezing
Cranial nerves
Brain equivailent to peripehral nerves
Obviously alot of muscles in neck and head which have to receive sensory info and to control motor info
Controlling toungue movement
Movement of eyes
12 crainial nerves
I
Olfactory nerve
Smell
II
Optic nerve
Back of each eye to brain
VIIII
Auditory nerve
Conveys sensory info needed for hearing
X
Vagus
Info from internal organs
Critically important for controlling parasympathetic nevous system
Sensory+ motor components
Cerebellum
A structure located deep in the hindbrain with many deep folds
Helps regulate motor movement
Balance and coordinaiton
Important for shifting attention between auditory and visual stimuli
Pons
Latin for bridge
contains structures important for sleep wake regulation
Neuronal types were originally defined by their shape
Also, can be described by number of poles on cell body: uni-, bi-, and multipolar
Multipolar
Stellate
Fusiform
Pyramidal
Classificiation is more based on molecular composition but we still use these terms
neuron
Input zone
dendrites
Integration zone
Between cell body and axon
Conducting zone
Axon
Output zone
Axon terminal
What makes them differnet
Structural Differences
Unipolar (or pseudo-unipolar) neurons: Have a single process extending from the cell body that splits into two branches—one acting as a dendrite and the other as an axon.
Bipolar neurons: Have two distinct processes attached to opposite sides of the cell body: one single dendrite and one single axon.
Multipolar neurons: Have three or more processes coming off the cell body, consisting of one single axon and multiple branching dendrites.
Types Neuron
Multipolar
Pyramidal
Cellbody in the middle
Dendrites coming from corners of a pyramid and top
Axon is coming off of the base
Fusiform
2 dendrite branches
Common brain cell type
Stellate
Star shaped
Processes coming off each end plus axon obv
Unipolar
Sensory Neuron
A sensory neuron is specialized at one end ot be highly sensitive to a particular type of stimulation
Bi polar
Motor neuron
Has its soma in the sinal cord and receives exicitation from other neurons and conducts impulses along its axon to a muscle.
Dendrites and Spines
Dendrites
Are the branching fibers lined with snuyaptic receptors that recieve info from other neurons
Contain dendrititic spines
Which are tiny protuberances prividing sites for postsynaptic contact
“highly plastic”
Allows rapid changes in connectiviity following environmental experience
As in neuroplasticitiy
Cell body
Cell body
Soma
Perikaryon
Contians the nucleus, mitochondria, ribosomes, and other structures found in other cells
More thinking of it as performing cells n
Translation of MRNA into proteins
Axon
Axon
Thin fiber responsible for transmitting nerve impulses toward other neurons, organs or muscle
Could be longer than three feet, axon in you leg go from the back.
Neurons only have one axon but it may branch many times
Bifurcate
Branching off
They do this to try to send signals in different directions
Presynaptic terminals or boutons
They have an insulating material called myelin sheath
It is a complicated lipid structure
Helps improve electrical efficiency
Everything that connects to spinal cord is myelinated
Nodes of Ranvier
allow rapid and efficient propagation of nerve impulses along myelinated axons via saltatory conduction
Relationship of neurons
Afferent axon
Refers to bringing info toward a structure
A- arriving too
Efferent
Refers to carrying info away from a structure
E- Exiting
Inter neurons
Neurons with dendrites and axons that are completely contained within a single structure
Fucutional divbisions of a neuron
Input zone
Mostly dendrites, some cell body, part of the neuron that contians all info that is coming in
Integration zone
Axon hillock
Cell body area where all incoming info into the neuron is combined to determine whether or not to send a signal of its own
Specialized part of axon where “decision is made”
Axon hillock
The “decision” is made at integration zone
Conduction zone
Part of axon where the electirical impulse will travel
Output zone
Outputs
Synapse
Pre Synapse
Space between the azon erminal/ button and the postsynaptic membranes of two neurons
Active zone
Region in the presynaptic button that regulates release of chemicals called neurotransmitters for communication with the neuron on the post synaptic side
Where the synaptic veisicles are located
Where the neurotransmitters are sitting
Neurotransmitters are specialezed chemical substances that are used to communicate with the post-synaptic neuron
The synapse is not a tight fit
Pause
Receptors
Specialized proteins that capture and react when the neurotransmitter binds n
Post synaptic side
Post synaptic Density
They are separate but info can be rapidly transferred
Protein dense network attached to the postsynaptic membrane
Contains like 1k proteins or more
This complexity is what makes synapses modifiable which we’ll return to with learning and memory
How to view neurons
Light microscopy
Shows cells and their processes using staining methods
This is what Golgi and Cajal had
Stained the cells
Shined light over it
Looked through light microscope
Electron microscopy
Also using staining
Mid 1900’s
Shine electrons on your sample
Makes it much higher resolution
Shows synapses and organelles
Fluorescence and confocal microscopy
Light based as well
But allows researcher to label specific cells of insttreat
Other Cells in the NS
Glia
Other major components of the nervous system that exchange chemicals with adjacent neurons
NS is 50% glial cells
1:1 in the brain
Astrocytes
Start chaped cells with numerous processes that extend in all direction
They can attach to neurons and blood vessels to regulate local blood flow and provide support to neurons
Astrocytes also participates in synaptic communicatin by having processes connecting nearby to the synapse
Seems like they are communicationg between vasculatur and neurons
Also involved in the formation of synapses and pruning of excess oens during development
Micro Glia
These cells extend
Kinda looks like astrocytes
Activated in response to injury
By growing and changing shape
Resident immune cell for nervous system
LIVE IN NS
They can form an area of containment around a site of damage and remove and destroy debris
Microglia are sometimes called the immune cells of the brain and spinal cord
Have roles in normal synapse formation and elimination
Oligodendrocytes
Central nervous system, build myelin
Schwann Cells
Peripheral
build the myelin sheath that surrounds axons of neurons
Radial glia
Guide the migration of neurons and the growth of their axons and dendrites during brain development and occasionally, during adulthood.
Blood Brian Barrier (BBB)
This is why the brian and spinal cord are compartmnetalized form the rest of hte body
Specialized barrier that limits info from blood stream, can be brought ot the brian
Not a real barrier
Provides an important layer of defense against invader
Virii
Bacteria
Harmful stuff
Brain is a spnge and holes in the brain is blood
BBB covers all vasculature to prevnet signals from blood to difuse into the brain
BBB has two layers
Endothelial cells that prvent diffusion in and out of blood vessels
Astrocytes that wrap around and support the endthelial cells
How can chemical pass through the BBB
Passive transport
When they r in blood stream, they can just diffuse freely
Anything in the blood that is lipid soluble can diffuse through BBB
Like
ALC
THC
O2
CO2
Hormes such as
Test
Estrogen
Active transport
Means that the substances across
And is more tightly regulated
Amino acids
Glucose
The mind brain relationship
Dualism
The belief that there are diff kinds of substance that exist independently
The non material soul is seperate from the mind and the body
Monism
The belief that the universe is only comprised of one type of substance
Forms
Materials- everything that exists is physical by nature
Mentalism- physical and psychological phenomena are mentally constructed and are therefore only explicable in terms of the mind
Identity position
mental processes and brain processes are the same but described in different terms
No feeling i can have is in absence of brain activity
Solves problem of mind brain rls
Brain functioning can be explained at a fundamental level in terms of neuronal and glial cell activity
Neuron
Primary cell in brain that communicate
Glial cells
Non neuronal support cells in the central and peripheral nervous systems that protect, insulate, and nourish neuron
A brief history of brain research and the origins of Neuroscience
Localization theory
Different parts of the brain serve different functions
Structures which look the same/diff should have same/diff functions
mostly recognized
Holism
Brian function is not localized instead, function is distributed more homogenously throughout
Motor functions are not localized to one area, carried out by the entire brain or a large part of the brain so much so you are unable to pinpoint
Holism is a neuro term 1800’s
Looking at the brain
Top – dorsal surface
Bottom- ventral surface
Brief (Eurocentric) history of brain research
BCE
Aristotle, Hippocrates, Plato,
Liver heart not as much brain
Mental processes come from other parts of the body, less of the brain
200 AD
Galen- surgeon from roman times
Documented hundreds of cases of people that he treated iin the military
Interesting form clinical standpoint
All diff types of head injuries
Swords and all that bs
One of the first people to recognize connection between head and brain injury and neurological impairment
Thought it was from the ventricles
Ventricles
Hollow fluid filled areas of the brain
Filled with CSF
This is waht they believed
Lateral ventricle
Sensory sutff
Middle
Fantasy ideation cognition
1500s
Da vinci and vesalius
Also thought it was the ventricles
1600s
Thomas willis
Proposed tat cerebreal hemisphered controlled memory and will
Imagition was tied to cerebral hemisphres
brain material was also implicated in sensation and movement
-cerebellum and brain stem were more involved in vital and
involuntary systems
Descartes
Proponent of dualism
Some of the functions that the brian was carrying out was mechanical in nature
Reflexive machine (brain was)
Rise of localization
Legallois (1770-1840)
Isolated a part of the respiratory center, to a specific part of the brain stem
V important finding
Bell magendie law
Dorsal spinal nerves root contains only sensory fibers, and ventral spinal roots contain only motor fibers
Led to rise of localitionist prospective
Previosly sensory and motor signals were believed to be mized
Bell first hypothesiszed this functional disticition in the spoinal cord
Magendie provided definitive support for this idea
Phrenology
Franz joesph gall
Put the idea of coritcal localization into play
1809 formulated phrenology idea that skull features were indicative of brain development such that specific faculties could be detected by surface features
Although initially popular
Idea behind it
Features of the skulls surface
Deformities and differences
Predicts feelings and genes
Because every skull looks different
The brian looked differnent under it
Ends up getting discredidted
Holism fills the vacuum
Flourents
Galls leading critic
Worked on birds
Thought it was how much brian he removed not where
Paul Broca
Brocas area
1861
Was the first to provide definitive proof of cortical localization not based on skull surface features
Examined case of monsieur Leborngne who had inability to form speech
Leborgne died
And upon postmortem analysis revealed specific damage to a relativley discrete portion of the inferior frontal gyrus
Another dude pulled up
Had deadass the same issue
Broca looked at both of their issues
Realized there was a specific lesion in the frontal cortex of both men
Localized in the left hemisphere
Motor Cortex discovered in monkey (humans)
Fritz and Hitzig 1870
The neuron doctrine
Started with development of cell theory in 1800s
Most scientists thought that branches of nerve cells formed a continuous net, sometimes called the nerve net theory, and this view also was used against the idea of cortical localization
Theodore Schwann 1810-1872
First to propose neuron doctrine in 1839
That the entire body including the nervous system was made up of individual cells
Camillo golgi (1840-1926)
Developed a silver staining procedure that allowed for visualizing occasional cells
Golgi Staining
Santiago Ramon y Cajal 1852-1934
Began to work with silver stains and made significant technical improvements to the method
Cajal amassed a massive archive of anatomical data describing neuron structure
Cajals Neuron doctine
Revealed cells
Werent just connected in web like manner,
Cells were dicontinuous
Starting and ending points
Over time his discoveries became widely accepted
Cajals work also privded considerable insight into the cell and brian function
Cajal is goatmaxxing
Used golgi stain to look at diff cell layers in cortex
Cut gyrus (ridges of cortex)
Used golgi staining
Visual cortex
Motor cortex
Layering patterns were diff in both
Korbinian Brodmann 1909
Looked at cellular features of all major areas of the cortex
Basiclaly said
As long as the cells in the area look similar then i mark them for an area
Mapped out the entire brain and differnet sections of the brain
By layering patterns
Mapping of cortical areas
Localization to connectionism
Follow up work studying the anatomy of the cerebral cortex revelaed dramatic diff in Cytoarchitecture that we now know accounts for many functions
Connectionsm
suggests that mental
phenomena and behavior can be described in
terms of interconnected brain regions
subserving different (sub)functions
Connectism has been and remains the dominant conceptual framwork for understanding brain function
Edward thorndike
William james
John hughlings jackson
Neurons are the basic elements for connectivity in the brain their spatial relationships are critically important
Biological sturcture predicts function
“If you want to understand function, study structure”- Francis Crick
The cell sof the nervous system
Neurons
86 billion neurons and around the same about of glia
Neurons are similar to other cells of the body but have a distinct shape
Shape of a neuron determines its connections with other neurons and its contirbution to the nervous system
The function of a neuron is related to its shape (although the molecular composition of the cell is also important)
Glia
All neurons have the following major compnents
Dendrites 1
Soma/ Cell body 2
Axon 3
Presynaptic terminals 4
Synapses 5
Always done 1->5
Neurons have many dendrites but only one axon
Descibe as pre and post synaptic neurons
Synapse
Junctional points between neurons (seperated by a small gap)
That tramsits/ receives electircal or chemical impulses
To keep this concise and easy to review, here are core definitions for the key terms shown in your behavioral neuroscience textbook list:
A–C
Acetylcholine (ACh): A major neurotransmitter involved in motor control, memory, and attention.
Afferent: Carrying sensory information toward the central nervous system.
Amygdala: A limbic system structure key for emotional processing, particularly fear and threat detection.
Angiography: Imaging technique used to visualize the location and size of blood vessels in the brain.
Anterior: Toward the front or head end of the body or brain.
Arachnoid: The web-like middle layer of the meninges surrounding the brain and spinal cord.
Arborization: The elaborate branching pattern of a neuron's dendrites.
Astrocyte: A star-shaped glial cell providing metabolic support, blood-brain barrier maintenance, and synaptic regulation.
Autonomic Nervous System: Branch of the peripheral nervous system regulating involuntary functions (heart rate, digestion).
Axon: The long extension of a neuron that conducts electrical impulses away from the cell body.
Axon Hillock: The cone-shaped region where the axon emerges from the cell body; site of action potential initiation.
Axon Terminal: The end of an axon branch that forms a synapse and releases neurotransmitters.
Basal Ganglia: Subcortical structures (caudate, putamen, globus pallidus) essential for motor control and habit learning.
Blood-Brain Barrier: Selective vascular barrier protecting the brain from toxins and pathogens in the bloodstream.
Brainstem: Brain region comprising the midbrain, pons, and medulla, controlling fundamental life-support functions.
Caudal: Toward the tail or posterior end.
Central Nervous System (CNS): The brain and spinal cord.
Cerebellum: Brain structure responsible for motor coordination, balance, and fine motor learning.
Cerebral Cortex: Outer layer of neural tissue covering the cerebral hemispheres, responsible for higher-order cognitive functions.
Cerebrospinal Fluid (CSF): Fluid cushioning the brain and spinal cord, circulating through the ventricles and subarachnoid space.
Corpus Callosum: The large tract of nerve fibers connecting the left and right cerebral hemispheres.
D–L
Dendrite: Branching extension of a neuron that receives synaptic inputs from other cells.
Diffusion Tensor Imaging (DTI): MRI technique tracking water diffusion to map white matter fiber tracts in the live brain.
Dorsal: Toward the back or top of the head/brain.
Dura Mater: The tough, outermost layer of the meninges.
Efferent: Carrying motor signals away from the central nervous system toward muscles or glands.
Forebrain: Frontal division of the brain containing the cerebral hemispheres, thalamus, and hypothalamus.
Frontal Lobe: Anterior cortical region involved in executive function, decision-making, planning, and motor control.
Functional MRI (fMRI): Brain imaging method tracking blood-oxygenation changes to detect active brain regions.
Glial Cells: Non-neuronal brain cells (astrocytes, oligodendrocytes, microglia) providing structural, metabolic, and myelin support.
Gray Matter: Brain regions composed predominantly of neuronal cell bodies, dendrites, and unmyelinated axons.
Gyrus: A raised ridge or fold on the surface of the cerebral cortex.
Hippocampus: Limbic structure essential for explicit memory formation and spatial navigation.
Hypothalamus: Structure regulating homeostatic drives (hunger, thirst, temperature) and controlling the pituitary gland.
Interneuron: A neuron that communicates exclusively with other neurons within a local circuit.
Ipsilateral: Located on or affecting the same side of the body.
Limbic System: Interconnected network (hippocampus, amygdala, cingulate) mediating emotion, memory, and motivation.
M–P
Medulla: Lower brainstem structure controlling vital autonomic functions like respiration and heart rate.
Meninges: The three protective membranes (dura, arachnoid, pia) encasing the brain and spinal cord.
Microglial Cells: Immune cells of the central nervous system that clear cellular debris and respond to injury.
Midbrain: Middle portion of the brainstem containing structures like the tectum and tegmentum.
Motor Neuron: Neuron transmitting signals from the CNS to effector muscles or glands.
Myelin: Fatty sheath surrounding axons that accelerates action potential conduction.
Neuron: Primary signaling cell of the nervous system specialized for receiving, processing, and transmitting information.
Neuroplasticity: The ability of the nervous system to alter its structure and functional organization in response to experience or injury.
Neurotransmitter: Chemical messenger released at a synapse to convey signals between neurons.
Node of Ranvier: Gap in the myelin sheath along an axon where action potentials are regenerated.
Occipital Lobe: Posterior cortical region dedicated to visual processing.
Oligodendrocyte: Glial cell forming myelin sheaths around axons in the central nervous system.
Parasympathetic Nervous System: Division of the autonomic nervous system promoting "rest and digest" physiological responses.
Parietal Lobe: Cortical region processing somatosensory information and spatial awareness.
Peripheral Nervous System (PNS): All nerves and ganglia outside the brain and spinal cord.
Pia Mater: Delicate, innermost layer of the meninges directly adhering to the brain surface.
Pons: Brainstem region bridging the midbrain and medulla; involved in sleep, arousal, and facial motor control.
S–W
Schwann Cell: Glial cell providing myelin sheaths for axons in the peripheral nervous system.
Sensory Neuron: Neuron detecting internal or external stimuli and transmitting information to the CNS.
Substantia Nigra: Midbrain structure containing dopaminergic neurons crucial for movement control; degenerates in Parkinson's disease.
Sulcus: A groove or furrow separating gyri on the surface of the cerebral cortex.
Sympathetic Nervous System: Division of the autonomic nervous system mobilizing "fight or flight" responses.
Synapse: Functional junction where a presynaptic neuron communicates with a postsynaptic target cell.
Synaptic Cleft: The tiny fluid-filled gap separating presynaptic and postsynaptic membranes.
Temporal Lobe: Lateral cortical region involved in auditory processing, speech comprehension, and memory.
Thalamus: Major sensory relay station directing incoming sensory signals to appropriate cortical areas.
Ventral: Toward the belly or underside of the head/brain.
White Matter: Nervous tissue composed mainly of myelinated axons facilitating long-distance communication.
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