Signal Transduction

Signal Transduction in Immune Cells

Reading Assignment

• Book: The Immune System

• Edition: 5th Edition

• Author: Parham, P.

• Pages: $113-114$, $132-134$, $136-137$, $198$, $220-225$, $246$, $273-274$

Lecture Objectives

• List and diagram the components of the antigen receptor on $B$ and $T$ cells.

• Describe the role of signal transduction in cell communication.

• Describe the role of tyrosine kinases in signal transduction.

• Describe the role of $ITAMs$ in signal transduction.

• Describe the role of scaffolding and adaptor molecules.

• List and describe $PLC-\gamma$, $DAG$, $IP3$, calcineurin and small $G$-proteins.

• Describe the role of transcription factors.

• Describe the role of $TCR$ costimulation.

• Compare and contrast signal transduction in $B$ and $T$ cells.

• List and describe examples of other receptors that use $ITAMs$ and $ITIMs$.

Cellular Communication Overview

• Purpose: To generate intracellular signals that modify a cell's