Signal Transduction

Signal Transduction in Immune Cells

Reading Assignment

• Book: The Immune System

• Edition: 5th Edition

• Author: Parham, P.

• Pages: 113-114, 132-134, 136-137, 198, 220-225, 246, 273-274

Lecture Objectives

• List and diagram the components of the antigen receptor on B and T cells.

• Describe the role of signal transduction in cell communication.

• Describe the role of tyrosine kinases in signal transduction.

• Describe the role of ITAMs in signal transduction.

• Describe the role of scaffolding and adaptor molecules.

• List and describe PLC-\gamma, DAG, IP3, calcineurin and small G-proteins.

• Describe the role of transcription factors.

• Describe the role of TCR costimulation.

• Compare and contrast signal transduction in B and T cells.

• List and describe examples of other receptors that use ITAMs and ITIMs.

Cellular Communication Overview

• Purpose: To generate intracellular signals that modify a cell's