Week 1: Intro. to Behavior and Neurobiology

Why do we care about the neurobiology of behavior?

  • Opening question framing the topic of the course: neurobiology of behavior.

  • Sets up the motivation for linking brain mechanisms to actions and responses.

Neurobiology and Behavior: Definitions

  • neurobiology: a branch of the life sciences that deals with the anatomy, physiology, and pathology of the nervous system.

  • behavior: anything that an organism does involving action and response to stimulation.

  • Importance: understanding how the nervous system gives rise to behavior.

How we study behavior

  • Step 1: Decide what the behavior is and how we define it.

  • Step 2: Decide how we want to observe it or model it.

  • Step 3: Decide how we want to quantify it.

  • Step 4: Decide how to relate it to other behaviors and/or the brain.

  • In laboratory settings, we often design tasks to elicit certain behaviors and maximize behavioral ‘epochs’ or episodes to relate back to neural measures.

How we study neurobiology

  • Neurobiology encompasses the entire nervous system, examinable from:

    • the finest detail (molecular structure of individual proteins on cells),

    • to incredibly complex (how brains in their entirety function).

Levels of biological organization (progression from small to large)

  • Synaptic

  • Cellular

  • Circuits

  • Pathways

  • Networks

Choosing the optimal technique for your level of analysis

  • Core idea: Granular behavior ↔ granular approach to neurobiology; each can inform the other.

  • The methods discussed are most useful for the neuroscience of behavior.

In vivo with behavior

  • Animal models:

    • In vivo electrophysiology

    • Pharmacology (IP/ICV)

    • Optogenetics/chemogenetics

    • MEG (not usually in rodents)

    • fMRI (complicated, so also not really in small animals)

  • Humans:

    • In vivo electrophysiology (ephys) – recently more common

    • PET

    • EEG

    • MEG

    • fMRI

The brain as a behavior machine

  • Core function: the brain and nervous system guide behavior.

  • The sensory systems take in information from the environment.

  • The motor system enacts behavioral plans.

  • Everything that happens in between is the workings of the mind.

  • Relation to psychology: Psychology is the study of the mind, and the method we use to study psychology is through behavior.

A note on this class and what’s covered

  • This class will cover the TIP of the iceberg of information found in the textbook, readings, and lectures.

  • The iceberg metaphor emphasizes that what we cover is only a small portion of what is known about neurobiology and behavior.

  • The course aims to introduce core concepts, not exhaustively cover all material.

A note on this class and what’s covered (continued)

  • Reiteration of the same idea: we’ll cover a tip of the iceberg (again) of what we know about neurobiology and behavior, acknowledging there is much more to discover.

A note on this class and what’s covered (summative)

  • Emphasizes that what we know is only the tip of the iceberg and there is much more to discover about the neurobiology of behavior.

Scientific method

  • The scientific method as presented in the course materials frames how we study neurobiology of behavior.

  • Page references show the iterative nature of theory development, observations, questions, data gathering, and hypothesis testing.

Develop

  • General Theories: General theories must be consistent with most or all available data and with other current theories.

  • Make Observations: What do I see in nature? This can come from one’s own experiences, thoughts, or reading.

  • Think of Interesting Questions: Why does that pattern occur?

  • Gather Data to Test Predictions: Relevant data can come from the literature, new observations, or formal experiments. Thorough testing requires replication to verify results.

  • Refine, Alter, Expand, or Reject Hypotheses.

  • Develop Testable Predictions: If my hypothesis is correct, then I expect a, b, c.

  • Formulate Hypotheses: What are the general causes of the phenomenon I am wondering about?

  • Note: Several slides use slightly different wording or order (OCR/transcription variations):

    • Page 18–20 show variations such as: "Sterature" (likely intended "literature"), "m experiences" (likely "my experiences"), and minor wording shifts.

Scientific method (alternative wording across slides)

  • Develop General Theories

  • Make Observations

  • Think of Interesting Questions

  • Gather Data to Test Predictions

  • Refine, Alter, Expand, or Reject Hypotheses

  • Develop Testable Predictions

  • If my hypothesis is correct, then I expect a, b, c.

  • Formulate Hypotheses

  • What are the general causes of the phenomenon I am wondering about?

Notes on transcription variations

  • Page 18–20 include OCR errors that appear in transcripts: e.g., "Sterature" instead of "Literature" and "m experiences" instead of "my experiences".

  • These variations appear in multiple slides, reflecting imperfect transcription rather than content changes.

Assignment

  • Assignment due for next week: Sunday, August 31, 11:59 PM

  • Task: Submit 3 observations and accompanying questions (see Canvas).