Hollow, muscular organ
Function: Pumps blood throughout the body
Beats: Approximately 72 beats/min, totaling about 3 billion beats in a lifetime
Size: Approximately the size of a fist
Location: Mediastinum, situated between the 2nd and 5th rib, with 2/3 of its mass located to the left of the midline
Made of squamous epithelium supported by underlying connective tissue
Continuous with blood vessels and lines heart valves
Function: Provides a smooth interior surface for blood flow
Composed of cardiac muscle
Features a spiral arrangement of muscle fibers
Contains connective tissue, referred to as the "skeleton" of the heart
Thin outer layer of the heart
Contains blood vessels that supply the heart
Connects the pericardium at the apex
Function: Supports and protects the heart
Composed of three layers:
Epicardium (Visceral pericardium)
Parietal pericardium
Fibrous pericardium
Serous fluid within the pericardial space reduces friction between layers
Inflammation can lead to increased fluid, resulting in cardiac tamponade which compresses the heart and is life-threatening
Structure: Thin-walled chambers
Right Atria: Receives blood from inferior and superior venae cavae
Left Atria: Receives blood from the pulmonary veins
Vein Definition: A vessel that transports blood to the heart
Structure: Muscular walls
Right Ventricle: Pumps blood to the lungs via pulmonary arteries
Left Ventricle: Pumps blood to the body through the aorta (systemic pump)
Artery Definition: A vessel that carries blood away from the heart
Left Ventricle Thickness: Thicker wall due to the need to exert more force
Trace a drop of blood as it travels from the aorta through systemic circulation and back to the aorta.
Located between the atria and ventricles
Function: Control the flow of blood into the ventricles
Right AV Valve: Tricuspid
Left AV Valve: Bicuspid (Mitral)
Flaps or Cusps: Open when ventricular pressure is lower than atrial pressure
Closing Mechanism: Closes when ventricles contract, creating higher pressure than atrial pressure
Prevention of Backflow: Achieved by chordae tendineae (fibrous strings attaching the valve to ventricular walls)
Resemble a half moon
Right Valve: Pulmonic (pulmonary valve)
Left Valve: Aortic valve
Open when ventricles contract and pressure within ventricle exceeds vessel pressure; close when ventricle relaxes
Sounds Identification: Lub-Dub
Lub: AV valve closure
Dub: Semilunar valve closure
Locations for Auscultation: 2nd and 5th intercostal spaces
Murmurs: Result from incomplete closure and backflow of blood
Blood supply to the heart muscle (myocardium) primarily through the coronary arteries which branch from the aorta
Left Coronary Artery: Branches into the left anterior descending artery and circumflex artery (supplying left ventricle)
Right Coronary Artery: Branches into the posterior descending artery (supplying right ventricle)
Shunting Mechanism: Diversion of blood through an interventricular hole
Septal Defect: Left to right shunt (pressure higher in left side) or right to left shunt (due to stenosis of pulmonary artery, increasing right side pressure)
Causes of Narrowing: Due to plaque buildup or clot formation
Consequences: Lack of oxygen leads to ischemia (angina), potential cell death (necrosis)
Key Biomarkers: CPK, AST, LDH, troponin
Myocardial Infarction Treatment: Includes thrombolytics and surgical interventions