2.2.4-2.2.6

  • Endocrine system

  • Endocrine glands: hypothalamus, pituitary, thyroid adrenal glands, pancreas

  • Hormones

  • Karyotype

  • Meiosis

  • Diploid cell (2n), haploid cell (n)

  • Independent Assortment, Crossing Over

  • Nondisjunction, monosomy, trisomy

  • Chromosomal mutations (deletion, insertion, inversion, duplication, translocation)



Knowledge and Skills to Understand:

  1. Evaluate chromosome number and structure on a karyotype

  2. Model how the process of meiosis can lead to differences in chromosome number

  3. Explain how chromosomal differences impact structure and function of the human body

  4. Demonstrate how a karyotype can be used to evaluate the genetic health of an individual

  5. Ethical Scenario evaluation



2.2.6: A Family Affair

Vocab to Know: 

  • Familial Hypercholesterolemia (FH)

  • Direct-to-consumer (DTC) genetic test

  • Predisposition

  • Genealogy

  • Polymerase Chain Reaction (PCR)

  • Restriction Fragment Length polymorphism (RFLP)

  • Statins

  • Liver membrane cholesterol receptor protein



Knowledge and Skills to Understand:

  1. Know what Familial Hypercholesterolemia is, how it is inherited, the inheritance pattern, the effect on the body, possible lifestyle changes, therapies & medications to treat it, and the mechanism by which a mutated allele results in a defective protein, which results in disease in the body.

  2. Ethical Scenario: What are the pros and cons of knowing your genetic predisposition for disease/disorders?

  3. Know and practice the molecular biology techniques for gene testing (DNA extraction, PCR, restriction enzyme digest of DNA, and gel electrophoresis)

  4. Be able to synthesize complex medical info to diagnose disease/disorders.

  5. Be able to select/use appropriate tools, techniques and technologies to investigate medical questions (ex: be able to use gene testing, Punnett Squares and pedigree analysis to answer medical questions about the Kim Family).