U1 L5 Higher Mental Functions & Brain Waves
Brain Waves
- Normal brain function involves continuous electrical activity.
- An electroencephalogram (EEG) records this activity.
- Patterns of neuronal electrical activity recorded are called brain waves.
- Each person’s brain waves are unique, characterized by a continuous train of peaks and troughs.
- Wave frequency is expressed in Hertz (Hz).
Types of Brain Waves
- Alpha waves: Regular and rhythmic, low-amplitude, slow, synchronous waves indicating an "idling" brain.
- Beta waves: Rhythmic, more irregular waves occurring during the awake and mentally alert state.
- Theta waves: More irregular than alpha waves; common in children but abnormal in adults.
- Delta waves: High-amplitude waves seen in deep sleep and when the reticular activating system is damped.
Consciousness
- Encompasses perception of sensation, voluntary initiation and control of movement, and capabilities associated with higher mental processing.
- Involves simultaneous activity of large areas of the cerebral cortex.
- Is superimposed on other types of neural activity.
- Is holistic and totally interconnected.
- Clinical consciousness is defined on a continuum that grades levels of behavior: alertness, drowsiness, stupor, coma.
Sleep
- There are two major types of sleep:
- Non-rapid eye movement (NREM)
- Rapid eye movement (REM)
- One passes through four stages of NREM during the first 30-45 minutes of sleep.
- REM sleep occurs after the fourth NREM stage has been achieved.
Types and Stages of Sleep: NREM
- NREM stages include:
- Stage 1: Eyes are closed and relaxation begins; the EEG shows alpha waves; one can be easily aroused.
- Stage 2: EEG pattern is irregular with sleep spindles (high-voltage wave bursts); arousal is more difficult.
- Stage 3: Sleep deepens; theta and delta waves appear; vital signs decline; dreaming is common.
- Stage 4: EEG pattern is dominated by delta waves; skeletal muscles are relaxed; arousal is difficult.
Types and Stages of Sleep: REM
- Characteristics of REM sleep:
- EEG pattern reverts through the NREM stages to the stage 1 pattern.
- Vital signs increase.
- Skeletal muscles (except ocular muscles) are inhibited.
- Most dreaming takes place.
Sleep Patterns
- Alternating cycles of sleep and wakefulness reflect a natural circadian rhythm.
- Although RAS activity declines in sleep, sleep is more than turning off RAS.
- The brain is actively guided into sleep.
- The suprachiasmatic and preoptic nuclei of the hypothalamus regulate the sleep cycle.
- A typical sleep pattern alternates between REM and NREM sleep.
Importance of Sleep
- Slow-wave sleep is presumed to be the restorative stage.
- Those deprived of REM sleep become moody and depressed.
- REM sleep may be a reverse learning process where superfluous information is purged from the brain.
- Daily sleep requirements decline with age.
Sleep Disorders
- Narcolepsy: Lapsing abruptly into sleep from the awake state.
- Insomnia: Chronic inability to obtain the amount or quality of sleep needed.
- Sleep apnea: Temporary cessation of breathing during sleep.
Locus Coeruleus
- Is active when we are awake. They produce Nor that causes “fight –or-flight” response.
- Is inactive when we are sleeping. No motor activity results from cortical stimuli because they are prevented from reaching the spinal cord.
Memory
- Memory is the storage and retrieval of information.
- The three principles of memory are:
- Storage – occurs in stages and is continually changing
- Processing – accomplished by the hippocampus and surrounding structures
- Memory traces – chemical or structural changes that encode memory
Stages of Memory
- The two stages of memory are short-term memory and long-term memory.
- Short-term memory (STM, or working memory): A fleeting memory of the events that continually happen.
- STM lasts seconds to hours and is limited to 7 or 8 pieces of information.
- Long-term memory (LTM) has limitless capacity.
Transfer from STM to LTM
- Factors that affect transfer of memory from STM to LTM include:
- Emotional state: We learn best when we are alert, motivated, and aroused.
- Rehearsal: Repeating or rehearsing material enhances memory.
- Association: Associating new information with old memories in LTM enhances memory.
- Automatic memory: Subconscious information stored in LTM.
Categories of Memory
- The two categories of memory are fact memory and skill memory.
- Fact (declarative) memory:
- Entails learning explicit information.
- Is related to our conscious thoughts and our language ability.
- Is stored with the context in which it was learned.
- Involves the following brain areas:
- hippocampus and the amygdala, both limbic system structures
- specific areas of the thalamus and hypothalamus of the diencephalon
- ventromedial prefrontal cortex and the basal forebrain
- Skill memory:
- Skill memory is less conscious than fact memory and involves motor activity.
- It is acquired through practice.
- Skill memories do not retain the context in which they were learned.
- Involves the following brain areas:
- Corpus striatum – mediates the automatic connections between a stimulus and a motor response
- Portion of the brain receiving the stimulus
- Premotor and motor cortex
Mechanisms of Memory
- Neuronal RNA content is altered.
- Dendritic spines change shape.
- Extracellular proteins are deposited at synapses involved in LTM.
- Number and size of presynaptic terminals may increase.
- More neurotransmitter is released by presynaptic neurons.
- New hippocampal neurons appear.
- Long-term potentiation (LTP) is involved and is mediated by NMDA receptors.
- Synaptic events involve the binding of brain-derived neurotropic factor (BDNF).
- BDNF is involved with Na+, Ca2+, and Mg2+ influence at synapses.