U1 L5 Higher Mental Functions & Brain Waves

Brain Waves

  • Normal brain function involves continuous electrical activity.
  • An electroencephalogram (EEG) records this activity.
  • Patterns of neuronal electrical activity recorded are called brain waves.
  • Each person’s brain waves are unique, characterized by a continuous train of peaks and troughs.
  • Wave frequency is expressed in Hertz (Hz).

Types of Brain Waves

  • Alpha waves: Regular and rhythmic, low-amplitude, slow, synchronous waves indicating an "idling" brain.
  • Beta waves: Rhythmic, more irregular waves occurring during the awake and mentally alert state.
  • Theta waves: More irregular than alpha waves; common in children but abnormal in adults.
  • Delta waves: High-amplitude waves seen in deep sleep and when the reticular activating system is damped.

Consciousness

  • Encompasses perception of sensation, voluntary initiation and control of movement, and capabilities associated with higher mental processing.
  • Involves simultaneous activity of large areas of the cerebral cortex.
  • Is superimposed on other types of neural activity.
  • Is holistic and totally interconnected.
  • Clinical consciousness is defined on a continuum that grades levels of behavior: alertness, drowsiness, stupor, coma.

Sleep

  • There are two major types of sleep:
    • Non-rapid eye movement (NREM)
    • Rapid eye movement (REM)
  • One passes through four stages of NREM during the first 30-45 minutes of sleep.
  • REM sleep occurs after the fourth NREM stage has been achieved.

Types and Stages of Sleep: NREM

  • NREM stages include:
    • Stage 1: Eyes are closed and relaxation begins; the EEG shows alpha waves; one can be easily aroused.
    • Stage 2: EEG pattern is irregular with sleep spindles (high-voltage wave bursts); arousal is more difficult.
    • Stage 3: Sleep deepens; theta and delta waves appear; vital signs decline; dreaming is common.
    • Stage 4: EEG pattern is dominated by delta waves; skeletal muscles are relaxed; arousal is difficult.

Types and Stages of Sleep: REM

  • Characteristics of REM sleep:
    • EEG pattern reverts through the NREM stages to the stage 1 pattern.
    • Vital signs increase.
    • Skeletal muscles (except ocular muscles) are inhibited.
    • Most dreaming takes place.

Sleep Patterns

  • Alternating cycles of sleep and wakefulness reflect a natural circadian rhythm.
  • Although RAS activity declines in sleep, sleep is more than turning off RAS.
  • The brain is actively guided into sleep.
  • The suprachiasmatic and preoptic nuclei of the hypothalamus regulate the sleep cycle.
  • A typical sleep pattern alternates between REM and NREM sleep.

Importance of Sleep

  • Slow-wave sleep is presumed to be the restorative stage.
  • Those deprived of REM sleep become moody and depressed.
  • REM sleep may be a reverse learning process where superfluous information is purged from the brain.
  • Daily sleep requirements decline with age.

Sleep Disorders

  • Narcolepsy: Lapsing abruptly into sleep from the awake state.
  • Insomnia: Chronic inability to obtain the amount or quality of sleep needed.
  • Sleep apnea: Temporary cessation of breathing during sleep.

Locus Coeruleus

  • Is active when we are awake. They produce Nor that causes “fight –or-flight” response.
  • Is inactive when we are sleeping. No motor activity results from cortical stimuli because they are prevented from reaching the spinal cord.

Memory

  • Memory is the storage and retrieval of information.
  • The three principles of memory are:
    • Storage – occurs in stages and is continually changing
    • Processing – accomplished by the hippocampus and surrounding structures
    • Memory traces – chemical or structural changes that encode memory

Stages of Memory

  • The two stages of memory are short-term memory and long-term memory.
  • Short-term memory (STM, or working memory): A fleeting memory of the events that continually happen.
    • STM lasts seconds to hours and is limited to 7 or 8 pieces of information.
  • Long-term memory (LTM) has limitless capacity.

Transfer from STM to LTM

  • Factors that affect transfer of memory from STM to LTM include:
    • Emotional state: We learn best when we are alert, motivated, and aroused.
    • Rehearsal: Repeating or rehearsing material enhances memory.
    • Association: Associating new information with old memories in LTM enhances memory.
    • Automatic memory: Subconscious information stored in LTM.

Categories of Memory

  • The two categories of memory are fact memory and skill memory.
  • Fact (declarative) memory:
    • Entails learning explicit information.
    • Is related to our conscious thoughts and our language ability.
    • Is stored with the context in which it was learned.
    • Involves the following brain areas:
      • hippocampus and the amygdala, both limbic system structures
      • specific areas of the thalamus and hypothalamus of the diencephalon
      • ventromedial prefrontal cortex and the basal forebrain
  • Skill memory:
    • Skill memory is less conscious than fact memory and involves motor activity.
    • It is acquired through practice.
    • Skill memories do not retain the context in which they were learned.
    • Involves the following brain areas:
      • Corpus striatum – mediates the automatic connections between a stimulus and a motor response
      • Portion of the brain receiving the stimulus
      • Premotor and motor cortex

Mechanisms of Memory

  • Neuronal RNA content is altered.
  • Dendritic spines change shape.
  • Extracellular proteins are deposited at synapses involved in LTM.
  • Number and size of presynaptic terminals may increase.
  • More neurotransmitter is released by presynaptic neurons.
  • New hippocampal neurons appear.
  • Long-term potentiation (LTP) is involved and is mediated by NMDA receptors.
  • Synaptic events involve the binding of brain-derived neurotropic factor (BDNF).
  • BDNF is involved with Na+Na+, Ca2+Ca2+, and Mg2+Mg2+ influence at synapses.