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Protein Kinase C (PKC) is a crucial enzyme involved in various cellular processes, playing a significant role in neurological health, particularly in the context of Alzheimer's Disease (AD) and chronic alcohol consumption. PKC regulates synaptic plasticity, learning, and memory in the brain. Dysregulation of PKC is linked to neurodegenerative diseases like AD, where it affects cognitive functions and neuronal survival through mechanisms such as tau phosphorylation and amyloid beta processing. Chronic alcohol consumption also alters PKC signaling pathways, contributing to neuroinflammation and cognitive impairments. The relationship between PKC and these conditions underscores its potential as a therapeutic target for neuroprotection and the management of addiction-related behaviors. This review discusses the dual role of PKC in neuroprotection versus neurodegeneration and highlights its interplay with inflammation and synaptic dysfunction, emphasizing the need for research into treatment strategies that modulate PKC activity.

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