Evolution and Sickle-Cell Anemia
Normal blood cells vs. sickle-shaped cells
Sickle-cell anemia can cause blockages in blood flow.
Explanation of how sickle-cell anemia has survived through natural selection despite its detrimental effects in certain environments (refer to pages 74-74).
Certain environmental conditions can favor genes which are otherwise harmful.
Neurons Overview
Neurons are specialized nerve cells responsible for transmitting information.
Parts of a Neuron:
Dendrites: Receive messages (like roots of a tree).
Soma (Cell Body): Contains nucleus and organelles.
Axon: Long projection that transmits impulses.
Terminals: Release signals to other neurons.
Myelin: Insulating cover for some axons, speeds up transmission of signals.
Glial Cells: Supportive cells which nourish neurons, eliminate waste, and direct growth.
Synapse: The gap between terminal buttons of one neuron and dendrites of another.
Firing Process:
Impulse travels down axon (action potential).
Release of neurotransmitters at the terminal end to communicate with the next neuron.
All-or-None Principle:
Neurons transmit impulses of uniform strength.
Stronger stimuli lead to more frequent firings.
Refractory Period:
Time post-firing when a neuron recovers before firing again.
Neurotransmitters:
Chemical messengers that cross synapses to facilitate neuron communication.
Receptor Sites: Located on receiving neurons’ dendrites.
Reuptake Process: Some neurotransmitters are reabsorbed by the releasing neuron after synaptic transmission.
Reuptake Mechanism:
Neurotransmitters reabsorb into the sending terminal for recycling.
Nervous System Structure:
Divided into two major parts:
Central Nervous System (CNS)
Peripheral Nervous System (PNS)
Somatic Nervous System:
Controls voluntary movements; carries information to and from the brain via sensory and motor neurons.
Autonomic Nervous System:
Regulates involuntary functions; divided into:
Sympathetic Division: Activates during stress, uses energy.
Parasympathetic Division: Calms the body, replenishes energy.
Opposite Effects of Divisions:
Sympathetic and parasympathetic systems have contrasting experiences impacting heart rate, digestion, etc.
Spinal Cord:
Connects brain to body; relay center for reflexes and bodily functions. Contains gray and white matter.
Reflex Arc:
Quick, unlearned responses to stimuli, involving gray and white matter.
Gray matter signals muscles quickly, while white matter sends messages to the brain, justifying the delay in perception of movement.
Corpus Callosum:
Connects hemispheres of the brain for communication.
Brain Divisions:
Forebrain, Midbrain, and Hindbrain; each with specialized functions.
Cerebral Cortex: Divided into left and right hemispheres.
Lobes of the Cortex:
Occipital Lobe: Vision.
Temporal Lobe: Hearing and language functions.
Parietal Lobe: Somatosensory input.
Frontal Lobe: Executive functions (planning, decision-making) and motor cortex (controls movement).
Somatosensory Cortex:
Processes sensory information with spatial relationships mirrored in its organization.
Language Areas:
Broca's Area: Speech production.
Wernicke's Area: Speech comprehension; damage leads to distinct language deficits.
Key Components:
Hippocampus: Involved in memory.
Amygdala: Emotional responses; associates memories with emotions.
Hypothalamus: Regulates body temperature, appetite, blood pressure.
Reticular Formation:
Regulates attention, sleep, and alertness; sends signals from lower brain to cortex.
Plays a role in filtering sensory information.
Hindbrain Components:
Medulla: Manages autonomic functions (heart rate, blood pressure).
Pons: Bridges communication from lower brain to higher functions.
Cerebellum: Coordinates movements and balance.
Research Methods:
Case studies, animal research, and various brain imaging techniques (EEG, CT, PET, MRI, fMRI).
Overview of imaging methods:
CAT/CT Scan: X-ray imaging for brain structures.
MRI: Uses magnetic fields for detailed images.
fMRI: Monitors real-time brain activity.
General Overview:
Ductless glands release hormones into the bloodstream; major glands include the hypothalamus and pituitary gland.
Pituitary Gland:
The master gland that secretes hormones influencing other glands.
Growth hormone; parenting behavior hormones.
Pineal Gland: Secretes melatonin, regulating sleep.
Function: Secretes epinephrine (adrenaline) and cortisol to manage stress responses.
Pancreas: Regulates blood sugar levels; issues lead to diabetes.
Gonadal Functions:
Testes: Secrete testosterone, influencing male characteristics and aggression.
Ovaries: Secrete estrogen and progesterone, regulating female features and menstrual cycle.