Bacteriophages Notes

Bacteriophages

What are Bacteriophages?

  • Bacteriophages, often called phages, are viruses that specifically infect bacteria.
  • They are generally considered harmless to humans, animals, and plants.
  • Phages exhibit host-specificity, meaning they only infect particular types of bacteria.
  • They replicate within a host bacterium.
  • The presence of phages suggests the presence of their bacterial hosts.
  • Phage detection is a promising strategy for detecting microbial contamination in water due to its sensitivity compared to standard bacterial detection methods.

Discovery of Bacteriophages

  • 1896: Ernest Hanbury Hankin reported antibacterial action against cholera in the Ganges and Yamuna rivers in India; this agent could pass through fine porcelain filters.
  • 1915: Frederick Twort, a British bacteriologist, discovered an agent capable of infecting and killing bacteria.
  • Twort's research was interrupted because of World War I, funding shortage and antibiotic discoveries.
  • September 3, 1917: Félix d'Hérelle, a French-Canadian microbiologist working at the Pasteur Institute in Paris, announced the discovery of