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Structure and Function of the Nervous System

Overview of the Nervous System

  • Central Nervous System (CNS):
    • Main processing center for sensory information.
    • Involves the spinal cord and brain.
  • Peripheral Nervous System (PNS):
    • Includes all nerves outside the CNS.
    • Responsible for transmitting sensory input and motor output; analogous to a computer's peripherals (mouse, keyboard, monitor).

Neurons: Basic Structure

  • Structure of a Neuron:
    • Cell Body (Soma): Contains the nucleus.
    • Axon: Transmits signals away from the cell body.
    • Axon Terminals: Where signaling to another neuron occurs via neurotransmitter release.
    • Myelin Sheath: Insulating layer that increases the speed of signal transmission along the axon.

Types of Glial Cells

  • Support neurons; outnumber neurons approximately 100 to 1.
  • Oligodendrocytes: Produce myelin in the CNS.
  • Schwann Cells: Produce myelin in the PNS.
  • Astrocytes: Provide support and nutrients; assist in transmission of information.
  • Microglia: Act as the immune cells in the CNS, specifically adapted to avoid damaging neurons due to their inflammatory responses.

Brain Anatomy

  • Divided into two hemispheres, connected by the corpus callosum.
Major Lobes of the Brain:
  1. Frontal Lobe:

    • Contains the motor cortex (controls voluntary movements), prefrontal cortex (decision-making, planning), and Broca's area (speech production).
    • Develops up to age 25.
  2. Temporal Lobe:

    • Involved in processing auditory information; key for understanding speech.
  3. Parietal Lobe:

    • Contains the somatosensory cortex, which handles sensory information such as touch.
  4. Occipital Lobe:

    • Primary visual processing center.
  5. Cerebellum:

    • Controls balance and coordination of movements.

Membrane Potential and Action Potentials

  • Resting Membrane Potential:

    • At rest, neurons have a potential of approximately -70 mV.
    • Inside of the cell is more negative compared to the outside; high concentrations of potassium inside and sodium outside.
  • Sodium-Potassium Pump:

    • Pumps 3 sodium ions out for every 2 potassium ions in, contributing to the negative potential inside the cell.
  • Action Potentials:

    • Triggered when the membrane potential reaches a threshold (around -55 mV), resulting in a rapid depolarization of the cell.
    • Sequence of voltage-gated sodium channels opening allows sodium to flow in, leading to a rapidly positive membrane potential.
    • After reaching around +40 mV, potassium channels open, bringing membrane potential back down during repolarization.
    • This process is an all-or-nothing response; any stimulus must exceed the threshold for true action potential generation.
  • Refractory Period:

    • The phase after action potential during which the neuron is less excitable; another action potential cannot be generated.

Types of Potentials

  • Graded Potentials: Triggered by synaptic inputs prior to reaching threshold for action potentials.

  • Hyperpolarization: Makes the neuron less likely to fire by making it more negative (moving away from 0).

  • Depolarization: Makes the neuron more likely to fire, towards reaching the threshold.

  • Summation of Potentials:

    • Temporal Summation: Rapid signals from the same synapse.
    • Spatial Summation: Simultaneous signals from multiple synapses.

Neuroplasticity

  • Process of brain changing and reorganizing itself in response to learning and experience.
    • Long-Term Potentiation (LTP): Strengthening of synapses based on recent patterns of activity.
    • Influence of repeated firing connections, leading to long-lasting enhancements in signal transmission.

Neurotransmitters and Their Functions

  • Acetylcholine: Associated with muscle activation, learning, and memory.

  • Amino Acid Neurotransmitters:

    • GABA (gamma-aminobutyric acid): Main inhibitory neurotransmitter.
    • Glutamate: Primary excitatory neurotransmitter, involved in many cognitive functions.
  • Biogenic Amines:

    • Dopamine: Involved in reward-motivated behavior and motor control. Degeneration leads to Parkinson's disease.
    • Serotonin: Regulates mood, anxiety, and happiness.
    • Norepinephrine: Involved in alertness and arousal; functions similarly to adrenaline.
  • Neuropeptides: Short chains of amino acids that modulate neurotransmitter effects.

  • Endocannabinoids: Signal molecules that influence synaptic transmission and neuroplasticity.

Disorder Overview

  • Depression: Mood disorder linked to imbalances in neurotransmitters like serotonin.
  • Bipolar Disorder: Characterized by alternating episodes of mania and depression due to neurotransmitter fluctuations.
  • Schizophrenia: Affects perception of reality, often connected to dopamine dysregulation.
  • Alzheimer's Disease: Neurodegenerative disease characterized by accumulation of amyloid plaques leading to cognitive decline.
  • Parkinson's Disease: Motor function disorder due to loss of dopamine-producing neurons; treated with dopaminergic medications.

Muscle Contraction Mechanism

  • Skeletal Muscle Structure: Comprised of muscle fibers containing actin and myosin.
  • Troponin and Tropomyosin: Proteins that regulate muscle contraction; calcium ions facilitate interaction between myosin and actin.
  • Contractile Cycle: Myosin heads attach to actin, using ATP for energy to pull the actin filaments (power stroke).

Sensory Systems

  • Vision: Caused by light waves within specific wavelengths (400-700 nm); involves photoreceptors (rods and cones).

    • Rods: Black and white vision.
    • Cones: Color vision, with specific types sensitive to red, green, and blue light.
    • Photopsins: Light-sensitive proteins in cone cells that begin the signal transduction for vision.
  • Hearing: Involves sound waves creating vibrations within the cochlea, stimulating hair cells that send signals to the brain.

  • Chemical Senses: Involve binding of molecules (odorants or tastants) to receptors, initiating signals for taste and smell.

    • Taste Buds: Detect different tastes using specialized receptors on papillae.
    • Olfactory Bulb: Directly processes smell signals; unique in that it bypasses the thalamus.

Connection between Sensory Input and Response

  • The sensory input is processed in the CNS, leading to appropriate motor responses through the effector neurons (efferent pathways).
  • Examples include voluntary muscle actions triggered through reflex arcs or conscious decision-making frameworks involving different systems (somatic and autonomic).