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Structure and Function of the Nervous System
Overview of the Nervous System
- Central Nervous System (CNS):
- Main processing center for sensory information.
- Involves the spinal cord and brain.
- Peripheral Nervous System (PNS):
- Includes all nerves outside the CNS.
- Responsible for transmitting sensory input and motor output; analogous to a computer's peripherals (mouse, keyboard, monitor).
Neurons: Basic Structure
- Structure of a Neuron:
- Cell Body (Soma): Contains the nucleus.
- Axon: Transmits signals away from the cell body.
- Axon Terminals: Where signaling to another neuron occurs via neurotransmitter release.
- Myelin Sheath: Insulating layer that increases the speed of signal transmission along the axon.
Types of Glial Cells
- Support neurons; outnumber neurons approximately 100 to 1.
- Oligodendrocytes: Produce myelin in the CNS.
- Schwann Cells: Produce myelin in the PNS.
- Astrocytes: Provide support and nutrients; assist in transmission of information.
- Microglia: Act as the immune cells in the CNS, specifically adapted to avoid damaging neurons due to their inflammatory responses.
Brain Anatomy
- Divided into two hemispheres, connected by the corpus callosum.
Major Lobes of the Brain:
Frontal Lobe:
- Contains the motor cortex (controls voluntary movements), prefrontal cortex (decision-making, planning), and Broca's area (speech production).
- Develops up to age 25.
Temporal Lobe:
- Involved in processing auditory information; key for understanding speech.
Parietal Lobe:
- Contains the somatosensory cortex, which handles sensory information such as touch.
Occipital Lobe:
- Primary visual processing center.
Cerebellum:
- Controls balance and coordination of movements.
Membrane Potential and Action Potentials
Resting Membrane Potential:
- At rest, neurons have a potential of approximately -70 mV.
- Inside of the cell is more negative compared to the outside; high concentrations of potassium inside and sodium outside.
Sodium-Potassium Pump:
- Pumps 3 sodium ions out for every 2 potassium ions in, contributing to the negative potential inside the cell.
Action Potentials:
- Triggered when the membrane potential reaches a threshold (around -55 mV), resulting in a rapid depolarization of the cell.
- Sequence of voltage-gated sodium channels opening allows sodium to flow in, leading to a rapidly positive membrane potential.
- After reaching around +40 mV, potassium channels open, bringing membrane potential back down during repolarization.
- This process is an all-or-nothing response; any stimulus must exceed the threshold for true action potential generation.
Refractory Period:
- The phase after action potential during which the neuron is less excitable; another action potential cannot be generated.
Types of Potentials
Graded Potentials: Triggered by synaptic inputs prior to reaching threshold for action potentials.
Hyperpolarization: Makes the neuron less likely to fire by making it more negative (moving away from 0).
Depolarization: Makes the neuron more likely to fire, towards reaching the threshold.
Summation of Potentials:
- Temporal Summation: Rapid signals from the same synapse.
- Spatial Summation: Simultaneous signals from multiple synapses.
Neuroplasticity
- Process of brain changing and reorganizing itself in response to learning and experience.
- Long-Term Potentiation (LTP): Strengthening of synapses based on recent patterns of activity.
- Influence of repeated firing connections, leading to long-lasting enhancements in signal transmission.
Neurotransmitters and Their Functions
Acetylcholine: Associated with muscle activation, learning, and memory.
Amino Acid Neurotransmitters:
- GABA (gamma-aminobutyric acid): Main inhibitory neurotransmitter.
- Glutamate: Primary excitatory neurotransmitter, involved in many cognitive functions.
Biogenic Amines:
- Dopamine: Involved in reward-motivated behavior and motor control. Degeneration leads to Parkinson's disease.
- Serotonin: Regulates mood, anxiety, and happiness.
- Norepinephrine: Involved in alertness and arousal; functions similarly to adrenaline.
Neuropeptides: Short chains of amino acids that modulate neurotransmitter effects.
Endocannabinoids: Signal molecules that influence synaptic transmission and neuroplasticity.
Disorder Overview
- Depression: Mood disorder linked to imbalances in neurotransmitters like serotonin.
- Bipolar Disorder: Characterized by alternating episodes of mania and depression due to neurotransmitter fluctuations.
- Schizophrenia: Affects perception of reality, often connected to dopamine dysregulation.
- Alzheimer's Disease: Neurodegenerative disease characterized by accumulation of amyloid plaques leading to cognitive decline.
- Parkinson's Disease: Motor function disorder due to loss of dopamine-producing neurons; treated with dopaminergic medications.
Muscle Contraction Mechanism
- Skeletal Muscle Structure: Comprised of muscle fibers containing actin and myosin.
- Troponin and Tropomyosin: Proteins that regulate muscle contraction; calcium ions facilitate interaction between myosin and actin.
- Contractile Cycle: Myosin heads attach to actin, using ATP for energy to pull the actin filaments (power stroke).
Sensory Systems
Vision: Caused by light waves within specific wavelengths (400-700 nm); involves photoreceptors (rods and cones).
- Rods: Black and white vision.
- Cones: Color vision, with specific types sensitive to red, green, and blue light.
- Photopsins: Light-sensitive proteins in cone cells that begin the signal transduction for vision.
Hearing: Involves sound waves creating vibrations within the cochlea, stimulating hair cells that send signals to the brain.
Chemical Senses: Involve binding of molecules (odorants or tastants) to receptors, initiating signals for taste and smell.
- Taste Buds: Detect different tastes using specialized receptors on papillae.
- Olfactory Bulb: Directly processes smell signals; unique in that it bypasses the thalamus.
Connection between Sensory Input and Response
- The sensory input is processed in the CNS, leading to appropriate motor responses through the effector neurons (efferent pathways).
- Examples include voluntary muscle actions triggered through reflex arcs or conscious decision-making frameworks involving different systems (somatic and autonomic).