article 3 i think
confronting risk of mirror life -
all things have homochirality. dna and rna are right handed(D) and proteins are left hannded (L) amino acids. so what scientist are trying to do it make a mirror image molcules. so from left to right and right to left. this is because scientist want to understand chirality and why nature chose it this way. they also want to see what happens in a mirror life.
Mirror life is at lest a decade away require technical advnacest and investments. They want to see early risk and if they should continue.
there are dangerous because there hasnt been a analysis done yet . there are risk of mirror bacteria because they can spread fast. and causes diseases. immune systems rely on chiral recognition. antibodies are build for regualr chirality molecules.
mirror bactiera would evade bacteriophages . and cause easier spred in the enviroment. it can be extreme because it can become an invasive species. mirror bactier could not be naturally contained.
again points - a decade away and needs large investments which gives us time to predict risk before we start.
the article is an analysis of technical barriers of technology and overlooked risks.
so it is not in nature mirror organisms and will never likely happen but scientist can make it. we have advnaced and made dna rna/ nucleotides and proteins that are mirror and we have seen that they dont degrade easily and arent triggered by the immune system which can be good for drugs and medicine where we canuse therapies that the immune system wont attack .
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scientist are building cells from scratch using dna, proteins,e tc. they still use the regular chiral orientations. so once they build one from scratch a regular one they can then start doing the same for mirror bacterium. so they can build it from scratch or they can take a natural chiral bacteira and then make it start producing mirror proteins and nucleic acids in vivo so that they can become mirror.
although it is expensive and complex . there needxs to be breathroughs.
in a controlled enviroment mirror bacteria could work like regular bactiera if they are fed nutrients that are mirror like or achiral. normal nutrinets wouldnt fit their enzymes.
scientist could take slow growing mirror bactier into. a fast growign bactiera . some bacteria dont need nutrients of specifial chirlaity therefore mirror bactera would grwo fast.
a chiral nutrients are aiable so mirror bactiera could grow in a regular envioment.
immune systems are build to recognize specific chiral bacteria to defend the body against it therefore mirror bactiera would result in weaker immune regonizion and a weaker first line of dense immunity/innate immune systems/ meaning our body fails to recognize and then adaptive immune like anitbodies will not activate properly.
a normal immune function. proteins are broken down into peptides. peptides are presented to immune cells to activate adpative reposne like anitbodies.
mirro rproteins will restist being broken down and fail to trigger antibodies.
therefore vetebrates immune systems will not happen.
mirror bacteria would be able to cross skin mouth gut lungs and they wouldnt need to adapt because they are going to always be able to attack the body. mirror bactiera can cause real infection in healthy hosts. it can be lethal. ,