Extracellular Main Matrix

Etymology and Definition of Extracellular Main Matrix

• Etymological components:

  • Extra means outside.

  • Cellular means related to cells.

  • Matrix means a supporting network.

• Overall definition: Extracellular matrix means the supporting material outside cells.

Structural Components of the Extracellular Main Matrix

• The extracellular main matrix contains four major constituent materials arranged directly around cells:

  • Collagen

  • Elastin

  • Proteoglycans

  • Glycopreathes

Functions and Biological Importance

• Specific functional capabilities provided by the extracellular matrix:

  • Support

  • Strength

  • Elasticity

  • Cell attachment

  • Signals that influence cell behavior

• Biological processes and states for which the extracellular matrix is essential:

  • Tissue strength

  • Organization

  • Healing

  • Normal cell function

Permeability and Transport Characteristics

• The passage of substances through the extracellular matrix is governed by two key criteria:

  • Size:

  • Smaller things get through easily.

  • Polarity or charge:

  • Non-polar, uncharged things get through easily.