Aspirin

What is it? Antiplatelet

How does it work? Irreversibly inhibits cyclo-oxygenase (COX), reducing thromboxane A₂ production and therefore reducing platelet aggregation.

When do I use it?

·         Suspected ACS

·         Acute cardiogenic pulmonary oedema

How do I use it?

Adult dose: oral tablet – 300mg – chewed and followed by a small sip of water

Contraindications:

·         Allergy AND/OR adverse drug reaction or aspirin OR any non-steroidal anti-inflammatory drug (NSAID)

·         Bleeding or clotting disorders

·         Current GI bleeding or peptic ulcers

·         Patients less than 18 years of age

Precautions:

·         Possible aortic aneurysm or any other condition that may require surgery

·         Pregnancy

·         History of GI bleeding or peptic ulcers

·         Concurrent anticoagulant therapy

What do I need to watch for?

·         Epigastric pain/discomfort

·         Nausea and/or vomiting

·         Gastritis

·         GI bleeding

·         NSAID induced bronchospasm