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three functions of the nervous system
control and interpret sensations and muscle movements; primary communication and control system; integrate and regulate body functions
sensory - functionality division
specialized to detect stimuli
interneurons neurons
lie entirely within the CNS; receive signal from many neurons and carry out the integrative function
motor - functionality division
send signals out to muscles and gland cells to the effectors
somatic - sensory
sensory input that is consciously perceived from receptors (eyes, skin ears)
visceral - sensory
sensory input that is not consciously perceived from blood vessels and internal organs (heart)
somatic - motor
motor output that is consciously or voluntarily controlled; effector is skeletal muscle
autonomic - motor
motor output that is not consciously or is involuntarily controlled; effectors are cardiac muscle, smooth muscle, and glands
neurons
basic structural unit of the nervous system; excitable cells that transmit electrical signals
neuroglia
non excitable cells that primarily support and protect neurons
excitability
most respond only to binding of molecules, neurotransmitters
conductivity
electrical charges propagated along membrane; can be local and short-lived or self-propagating
secretion
release neurotransmitters in response to electrical charges; given neuron releasing only one type of neurotransmitter
extreme longevity
most formed before birth still present in advanced age
amitotic
mitotic activity lost in neurons, not always the case; occasionally the hippocampus
axon
longer process emanating from cell body making contact with other neurons, muscle cells, or glands
axon hillock
triangular region of the axon
axon collaterals
side branches emitting from axon
telodendria
terminal branches
cell body
enclosed by plasma membrane and does not have centrioles
unipolar
single process leading away from the soma; sensory from skin and organs to spinal cord
bipolar
one axon; one dendrite; olfactory cells, retina, and inner ear
multipolar
one axon; multiple dendrites; most common; in brain and spinal cord
sensory - neuron classification
specialized to detect stimuli
motor - neuron classification
send signals out to muscles and gland cells (to the effectors)
interneurons
lie entirely within the CNS; receive, process, and store information; facilitate communication between sensory and motor neurons; 99% of neurons
endoneurium
delicate layer of areolar connective tissue that separates and electrically insulates each axon
perineurium
layer of dense irregular connective tissue wrapping bundles of axons, fascicles
epineurium
thick layer of dense irregular connective tissue enclosing the entire nerve
cranial nerves
12 nerves that originate from the brain or brainstem; numbered consecutively with different functions
spinal nerves
extend from the spinal cord (31 pairs)
motor - nerve classification
contains primarily motor neurons
sensory - nerve classification
contains only sensory neurons
mixed - nerve classification
contains both sensory and motor neurons; most named nerves are in this category; individual neurons transmitting one type of information
astrocytes
most abundant glial cell in CNS; anchor neurons; cover entire brain surface and most non synaptic regions of neurons in gray matter of the CNS
ependymal cells
lines internal cavities of brain; cuboidal epithelium with cilia on apical surface; secretes and circulates CSF
microglia
small wandering macrophages that phagocytize foreign particles; thought to perform complete checkup on brain tissue several times a day
oligodendrocytes
produce myelin sheaths in CNS; each arm like process wraps around a nerve fiber forming an insulating layer that speeds up signal conduction
satellite cells
arranged around neuronal cell bodies in ganglion; physically separate cell bodies in ganglion from surrounding fluid; regulate the exchange of nutrients and waste products
neurolemmocytes
envelope nerve fibers in PNS; wind repeatedly around a nerve fiber; produce a myelin sheath similar to the ones produced by oligodendrocytes in CNS; assist in the regeneration of damaged fibers; allow faster action potentials propagation
gyri
ridges on the outer surface of the brain
sulci
depressions between ridges
fissures
deep sulci
rostral
anterior
caudal
posterior
prosencephalon
the forebrain
mesencephalon
midbrain
rhombencephalon
hindbrain
telencephalon
arises from the prosencephalon and eventually forms the cerebrum
diencephalon
posterior region of the forebrain; includes the epithalamus, thalamus, and hypothalamus
metencephalon
arises from the rhombencephalon and eventually forms pons and cerebellum
myelencephalon
derives from the rhombencephalon and eventually forms the medulla oblongata
dura mater
tough leathery outermost layer composed of dense irregular connective tissue
arachnoid mater
spider web like middle layer composed of collagen and elastic fibers
pia mater
very thin innermost layer of areolar connective tissue conforming to the shape and contours of the brain
cranial dural septa
double layers of dura mater; separate specific parts of the brain and provide additional support
falx cerebri
formed by invagination of dura mater into longitudinal fissure
falx cerebelli
largest of the four dura septa
diaphragma sellae
smallest of the dura septa
2 lateral ventricles
two large cavities in cerebrum; separated by medial partition , septum
septum pellucidum
thin medial partition dividing the two lateral ventricles
third ventricle in diencephalon
narrow space in middle of diencephalon; connected to each lateral ventricle by an interventricular foramen
fourth ventricle
sickle-shaped space between pons and cerebellum; connected to the third ventricle by cerebral aqueduct; opens to subarachnoid space medially and laterally; narrows before merging with central canal of spinal cord
cerebrospinal fluid
clear colorless liquid that fills the ventricles and canals of CNS and bathes external surfaces; brain produces and absorbs 500 mL/day
buoyancy
reduces brain’s apparent weight by 95%
protection
provides a liquid cushion
environmental stability
transport of nutrients/wastes and protects against fluctations
choroid plexus
special tissue in each ventricle; layer of ependymal calls and blood capillaries within pia; produces by secretion from ependymal cells; originates from blood plasma; composition somewhat similar to plasma
blood brain barrier
regulates which substances enter brain’s interstitial fluid; helps prevent neuron exposure to harmful substances; drugs waste and abnormal solute concentrations; some drugs can pass through and affect the brain (alcohol)
perivascular feet
astrocyte extensions
longitudinal fissure
divides right and left hemispheres that make up the cerebellum
corpus callosum
how hemispheres communicate
hemisphere lateralization
specialization of each hemisphere for certain functions; some higher order functions exhibit lateralization and are primarily controlled by one side of the brain; left hemisphere receives sensory signals from the right side and sends motor signals to the right side
frontal lobe
motor control, concentration, verbal communication, decision making, planning, personality
central sulcus
border posterior to the frontal lobe
lateral sulcus
separates inferior frontal lobe from temporal lobe
precentral gyrus
controls voluntary movement
parietal lobe
superoposterior side of the cerebrum; serves general sensory functions (evaluating shape and texture of object)
parietal occipital sulcus
border posterior to the parietal lobe
postcentral gyrus
ridge just posterior to the central sulcus
temporal lobe
functions include hearing and smell
occipital lobe
functions in vision and visual memory
insula
small lobe that can be observed by pulling away temporal lobe; functions in memory and sense of taste
diencephalon
includes the epithalamus, thalamus, and hypothalamus
epithalamus
forms posterior part of roof of diencephalon, covers third ventricle
pineal gland
melatonin and circadian rhythm
habenular nuclei
relay signals from the limbic system to the midbrain and are involved in visceral and emotional response to odors
thalamus
oval masses of gray matter on lateral sides of third ventricle; receives signals from all conscious senses except olfaction; relays some signals to appropriate part of cortex and filters out other signals distracting from subject of attention (background noise in a crowded room)
interthalamic adhesion
small midline mass of gray matter that connects the right and left thalamic bodies
hypothalamus
anteroinferior region of the diencephalon
infundibulum
extends inferiorly from the hypothalamus and attaches to the pituitary gland
master control of the autonomic nervous system
hypothalamus; projects descending axons to nuclei in the brainstem that influence heart rate, blood pressure, digestive activities, and respiration
master control of the endocrine system
hypothalamus; secretes hormones that control secondary activities in the pituitary gland
regulation of body temperature
hypothalamus
control of emotional behavior
hypothalamus at the center of the limbic system; controls pleasure, aggression, sex drive, fear, rage, and contentment
control of food intake
neurons in the ventromedial nucleus monitor glucose and amino acids in the blood and produce hunger sensations
control of water intake
neurons in the anterior nucleus of the hypothalamus monitor the concentration of dissolved substances in the blood to regulate thirst
regulation of circadian rhythms
hypothalamus; suprachiasmatic nucleus directs the pineal gland to secrete melatonin
pons
forms a bulge on the ventral side of the brainstem that contains tracts and nuclei
pontine respiratory center
the vital center; regulates skeletal muscle of breathing