Formed during myelocyte stage and contains: Histamine, Platelet-activating factor, Leukotriene C4, IL-4 and IL-13, Vascular endothelial growth factors A and B, Chondroitin sulfate (eg. Heparan sulfate)
Basophil Secondary Granules
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Development and maturation of monocytes
Monopoiesis
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Precursor of macrophages
Monocytes
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Major cytokine responsible for growth and differentiation of monocytes
Macrophage Colony Stimulating Factor (M-CSF)
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Moprhologic stages of monocytes
Monoblasts, Promonocytes, Monocytes
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Size of Monoblast
12-20 um
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Cytoplasm of Monoblast
Basophilic
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Nucleus of Monoblast
Round to slightly indented with 1-2 nucleoli
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Nucleus to cytoplasm ratio of monoblast
3:1 to 4:1
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Size of Promonocytes
14-18 um
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Cytoplasm of Promonocytes
Blue-gray
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Nucleus of Promonocytes
irregularly shaped with 0-1 nucleoli
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Nucleus to cytoplasm ratio of promonocytes
2:1 to 3:1
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Last stage capable of mitosis and is confined to bone marrow
Promonocyte
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Size of Monocytes
14-20 um
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Cytoplasm of monocytes
blue-gray with ground glass appearance, with or without vacuoles
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Shape of the nucleus of monocytes
Kidney-bean shaped with brain-like convolutions
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The only stage found in the circulation, and the largest cell in the circulation