Leukopoiesis

0.0(0)
studied byStudied by 28 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/138

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

139 Terms

1
New cards
Nucleated cells that function in body defense
Leukocytes
2
New cards
Leukocytes are also known as?
White blood cells
3
New cards
This refers to production, development, and maturation of WBC
Leukopoiesis
4
New cards
Three main categories of Leukopoiesis
Granulopoiesis, Monopoiesis, Lymphopoiesis
5
New cards
Development of granulocytes
Granulopoiesis
6
New cards
Development of monocytes and macrophages
Monopoiesis
7
New cards
Development and maturation of lymphocyte
Lymphopoiesis
8
New cards
WBC with visible granules present in the cytoplasm
Granulocytes
9
New cards
Granulocytes include which cells?
Neutrophils, eosinophils, and basophils
10
New cards
What are the growth factors for granulopoiesis?
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Granulocyte Colony-Stimulating Factor (GCSF)
11
New cards
What is the cell size in diameter of myeloblast?
15-20 um
12
New cards
What is the cell size in diameter of promyelocyte?
15-21 um
13
New cards
What is the cell size in diameter of myelocyte?
12-18 um
14
New cards
What is the cell size in diameter of metamyelocyte?
10-15 um
15
New cards
What is the cell size in diameter of neutrophil, band?
9-15 um
16
New cards
What is the cell size in diameter of neutrophil?
9-15 um
17
New cards
What is the cell size in diameter of eosinophil?
9-15 um
18
New cards
What is the cell size in diameter of basophil?
10-16 um
19
New cards
What is the characteristic of the cytoplasm of myeloblast?
Basophilic/primary granules
20
New cards
What is the characteristic of the cytoplasm of promyelocyte?
Basophilic
21
New cards
What is the characteristic of the cytoplasm of myelocyte?
Secondary granules
22
New cards
What is the characteristic of the cytoplasm of neutro, band?
Lilac-pink granules
23
New cards
What is the characteristic of the cytoplasm of neutrophil?
Lilac-pink granules
24
New cards
What is the characteristic of the cytoplasm of eosinophil?
Reddish-orange granules
25
New cards
What is the characteristic of the cytoplasm of basophil?
Bluish-black granules
26
New cards
What is the shape of the nucleus in myeloblast?
Round to slightly oval
27
New cards
What is the shape of the nucleus in myelocyte?
Round to oval with flattened side
28
New cards
What is the shape of the nucleus in Metamyelocyte?
Indented
29
New cards
What is the shape of the nucleus in neutro, band?
C, S, or Z
30
New cards
What is the shape of the nucleus in neutrophil?
2-5 lobes
31
New cards
What is the shape of the nucleus in eosinophil?
2 lobes
32
New cards
What is the shape of the nucleus in basophil?
3-4 lobes
33
New cards
What is the nucleus to cytoplasm ratio in myeloblast?
4:1
34
New cards
What is the nucleus to cytoplasm ratio in promyelocyte?
3:1 to 2:1
35
New cards
What is the nucleus to cytoplasm ratio in myelocyte?
1:1
36
New cards
What is the nucleus to cytoplasm ratio in metamyelocyte?
Decreased
37
New cards
What is the characteristic/s of the nuclear chromatin in myeloblast?
Fine
38
New cards
What is the characteristic/s of the nuclear chromatin in promyelocyte?
Slightly coarser
39
New cards
What is the characteristic/s of the nuclear chromatin in myelocyte?
Coarse
40
New cards
What is the characteristic/s of the nuclear chromatin in metamyelocyte?
Coarse and clumped
41
New cards
What is the characteristic/s of the nuclear chromatin in neutro, band?
Coarse and clumped
42
New cards
What is the characteristic/s of the nuclear chromatin in neutrophil?
Coarse and clumped
43
New cards
What is the characteristic/s of the nuclear chromatin in eosinophil?
Coarse and clumped
44
New cards
What is the characteristic/s of the nuclear chromatin in basophil?
Coarse and clumped
45
New cards
How many nucleoli are present in myeloblast?
2-5
46
New cards
How many nucleoli are present in promyelocyte?
2-3
47
New cards
Earliest recognizable granulocytic precursor using light microscope
Myeloblast
48
New cards
What are the subtypes of myeloblast?
Type I Myeloblast, Type II and III Myeloblast
49
New cards
Has similar appearance to myeloblast
Monoblast
50
New cards
Which subtype of myeloblast has no visible granules?
Type I Myeloblast
51
New cards
Which subtype of myeloblast are granular?
Type II and III Myeloblast
52
New cards
Which stage of leukopoiesis has 1-6% of nucleated cells in the bone marrow?
Promyelocyte
53
New cards
Which stage of leukopoiesis has 1-2% of nucleated cells in the bone marrow?
Myeloblast
54
New cards
It is also known as non-specific, azurophilic granules
Primary granules
55
New cards
Primary granules contains?
Myeloperoxidase, Acid ß-glycerophosphatase, Cathepsins, Defensins, Elastase, Proteinase-3, Charcot-Leyden Crystal Protein
56
New cards
Last stage capable of mitosis
Myelocyte
57
New cards
Stage of secondary/specific granules synthesis
Myelocyte
58
New cards
Early myelocytes are also known as
Dawn of Neutrophilia
59
New cards
Metamyelocyte is also known as
Juvenile cells
60
New cards
Stage which is most abundant in normal bone marrow
Metamyelocyte
61
New cards
Stage of tertiary granules development
Metamyelocyte
62
New cards
These are formed during metamyelocyte to band stages
Tertiary granules
63
New cards
Tertiary granules contains?
Gelatinase, Collagenase, Lysozyme, Acetyltransferase, ß2-microglobulin
64
New cards
Which stage has 9-32% of nucleated cells in the bone marrow?
Neutrophil Bands/Stab/Staff
65
New cards
Which stage has 0-5% of nucleated cells in the circulation?
Neutrophil Bands/Stab/Staff
66
New cards
The youngest granulocytic precursor to normally appear in the peripheral blood
Neutrophil Bands/Stab/Staff
67
New cards
Start of Secretory Granules synthesis
Neutrophil Bands/Stab/Staff
68
New cards
Neutrophil secretory granules are also known as?
Secretory vesicles
69
New cards
It is formed during band to segmented stages
Neutrophil Secretory Granules
70
New cards
Neutrophil Secretory Granules contains?
CD11b/CD18, Alkaline phosphatase, Vesicle-associated membrane-2, CD10, CD13, CD14, CD16, Cytochrome b558, Complement 1q receptor, Complement receptor-1
71
New cards
It is also known as polymorphonuclear neutrophil (PMN)
Neutrophil (Segmented)
72
New cards
7-30% of nucleated marrow cells
Neutrophil (Segmented)
73
New cards
Nucleus in neutrophil (segmented) are connected by?
Thin filaments
74
New cards
These are formed during myelocyte stage
Neutrophil Secondary Granules
75
New cards
Neutrophil Secondary Granules contains?
ß2 -macroglobulin, Collagenase, Gelatinase, Lactoferrin, Neutrophil gelatinase-associated lipocalin (NGAL), Transcobalamin
76
New cards
1-3% of nucleated marrow cells
Eosinophils
77
New cards
Critical for eosinophil growth and survival
IL-5
78
New cards
Formed during myelocyte stage
Eosinophil Secondary Granules
79
New cards
Eosinophil Secondary Granules contains?
Major Basic Protein, Eosinophil cationic protein, Eosinophil-derived neurotoxin, Eosinophil peroxidase, Lysozyme, Catalase, β-glucoronidase, Cathepsin D, IL-2, IL-4, IL-6, GM-CSF
80
New cards
0-2% of circulating WBC,
Basophils
81
New cards
Formed during myelocyte stage and contains: Histamine, Platelet-activating factor, Leukotriene C4, IL-4 and IL-13, Vascular endothelial growth factors A and B, Chondroitin sulfate (eg. Heparan sulfate)
Basophil Secondary Granules
82
New cards
Development and maturation of monocytes
Monopoiesis
83
New cards
Precursor of macrophages
Monocytes
84
New cards
Major cytokine responsible for growth and differentiation of monocytes
Macrophage Colony Stimulating Factor (M-CSF)
85
New cards
Moprhologic stages of monocytes
Monoblasts, Promonocytes, Monocytes
86
New cards
Size of Monoblast
12-20 um
87
New cards
Cytoplasm of Monoblast
Basophilic
88
New cards
Nucleus of Monoblast
Round to slightly indented with 1-2 nucleoli
89
New cards
Nucleus to cytoplasm ratio of monoblast
3:1 to 4:1
90
New cards
Size of Promonocytes
14-18 um
91
New cards
Cytoplasm of Promonocytes
Blue-gray
92
New cards
Nucleus of Promonocytes
irregularly shaped with 0-1 nucleoli
93
New cards
Nucleus to cytoplasm ratio of promonocytes
2:1 to 3:1
94
New cards
Last stage capable of mitosis and is confined to bone marrow
Promonocyte
95
New cards
Size of Monocytes
14-20 um
96
New cards
Cytoplasm of monocytes
blue-gray with ground glass appearance, with or without vacuoles
97
New cards
Shape of the nucleus of monocytes
Kidney-bean shaped with brain-like convolutions
98
New cards
The only stage found in the circulation, and the largest cell in the circulation
Monocyte
99
New cards
Most abundant cell in the body
Tissue monocytes
100
New cards
Size of tissue monocytes
15-85 um