Core Drugs - Interactions

Aciclovir

Cimetidine, Theophylline

Aclidinium Bromide

Other anticholinergics

Adalimumab

Other biologics, Methotrexate

Adenosine

Dipyridamole, Xanthines

Adrenaline

Oxytocin, Alpha adrenergic blockers, Beta adrenergic blockers, General anaesthetic, Antidepressants, MAOIs, Antihypertensives, Phenothiazines, Drugs that induce arrhythmias

Alendronic Acid

Food and drink

Allopurinol

Azathioprine, Ramipril

Alteplase

Other anticoagulants, ACE inhibitors

Amiodarone

Drugs inducing Tordade de Pointes or long QT syndrome

Amitryptyline

MAOIs

Amlodipine

CYP3A4 inducers or inhibitors

Amoxicillin

Allopurinol, Tetracyclines, Oral anticoagulants

Apixaban

Rifampicin, Drugs increasing bleeding risk

Aripiprazole

Antihypertensive drugs

Atorvastatin

Cytochrome P450 inducers or inhibitors

Atropine

Tricyclic antidepressants, Antihistamines, Antiparkinsonian drugs, neuroleptic drugs, Antispasmodics, Clozapine

Beclomethasone

Live vaccines

Bendroflumethiazide

Other drugs causing electrolyte disturnbances

Betamethasone

Cytochrome P450 inducers or inhibitors

Bisoprolol

Calcium antagonists, Centrally acting antihypertensives

Carbamazepine

MAOIs, Cytochrome P450 inducers or inhibitors

Carbimazole

Anticoagulants, Erythromycin

Cefotaxime

Loop diuretics, Nephrotoxic drugs

Chlordiazepoxide

Alcohol, Centrally acting drugs, Narcotics, Anti-epileptics, Sedatives

Chlorphenamine

MAOIs, Phenytoin

Chlorpromazine

Citalopram, Dopaminergic drugs

Ciclosporin

Cytochrome P450 inducers or inhibitors

Cimetidine

Oral anticoagulants, Phenytoin

Citalopram

MAOIs, Pimozide

Clarythromycin

Drugs prolonging the QT interval, Lomitapide, Ergotamine, Statins

Clindamycin

Neuromuscular blocking agents, Vitamin K antagonists

Clonazepam

Alcohol, Centrally acting medication, Other antiepileptics

Clonidine

Other antihypertensives, Tricyclic antidepressants

Clopidogrel

Drugs increasing bleeding risk, NSAIDs, Cytochrome P450 inducers or inhibitors

Clozapine

Bone marrow function suppressants, Long acting antipsychotics, Alcohol

Co-Amoxiclav

Oral anticoagulants, Methotrexate, Probenecid

Codeine Phosphate

Alcohol, General anaesthetics, Anti-arrhythmic drugs, Tricyclic antidepressants, MAOIs, Antihistamines, Antipsychotics, Anxiolytics, Domperidone, Metoclopramide, Sodium oxybate

Colchicine

Cytochrome P450 inducers or inhibitors

Cyclizine

Other CNS depressants

Dabigatran

Other anticoagulants, SSRIs

Dexamethasone

Antidiabetic drugs, NSAIDs

Diazepam

Alcohol, Sodium oxybate, HIV protease inhibitors

Digoxin

Beta blockers, Agents reducing potassium, Calcium, Drugs precipitating arrhythmias

Diltiazem

Dantrolene

Domperidone

Drugs inhibiting CYP3A4 protease inhibitors, Antifungals, Drugs prolonging the QT interval

Donepazil

Cytochrome P450 inducers or inhibitors

Doxazosin

Phosphodiesterase-5-inhibitors

Doxycycline

Penicillin's, Warfarin, Ciclosporin, Methoxyflurate

Duloxetine

MAOIs, CYP1A2 inhibitors, Centrally acting sedatives, Serotonergic agents

Ethinylestradiol

Cytochrome P450 inducers or inhibitors

Ethinylestradiol and Cyproterone Acetate

Hormonal contraceptives, Cytochrome P450 inducers or inhibitors, Antiretrovirals, Anticonvulsants, Antibiotics

Ethosuximide

Valproic acid, Carbamazepine

Febuxostat

Azathioprine, Rosiglitazone, Theophylline, Naproxen

Flucloxacillin

Methotrexate, Paracetamol

Fluconazole

Terfenadine, Cytochrome P450 inducers or inhibitors, QT prolonging medications

Fludrocortisone

Medication affecting electrolyte levels, Anticoagulants, Antihypertensives, NSAIDs

Fluoxetine

MAOIs, Metoprolol

Flupenthixol

CNS depressants, Other drugs causing extrapyramidal side effects, Lithium, Drugs prolonging the QT interval, Drugs causing electrolyte disturbance, Tricyclic antidepressants

Folic Acid

Trimethoprim, Sulphonamides, Fluorouracil, Chloramphenicol

Formoterol

Diuretics

Furosemide

Antihypertensives, Antipsychotics, Anti-arrhythmics, Cardiac glycosides, QT prolonging drugs, Vasodilators, Renin inhibitors, Nitrates, Lithium, NSAIDs

Gabapentin

Opioids

Gentamicin

Ototoxic or nephrotoxic drugs, Oral anticoagulants, Bisphosphonates

Gestodene

Cytochrome P450 inducers or inhibitors

Gliclazide

Miconazole

Glycerol Trinitrate

Phosphodiesterase inhibitors, Vasodilators, Alcohol, Riociguat, Salicylic acid

Haloperidol

QT prolonging medications, Drugs causing electrolyte imbalance

Heparin

Diclofenac, Drugs increasing bleeding risk, Cephalosporins, ACE inhibitors, Angiotensin 2 receptor antagonists, Nitrates, Probenecid

Hydrocortisone

Cytochrome P450 inducers or inhibitors

Hyoscine Butylbromide

Other anticholinergics, Dopamine antagonists, Beta-adrenergic agents

Ibuprofen

Aspirin, Other NSAIDs

Indapamide

Lithium

Insulin

Drugs affecting blood glucose level

Ipratropium

Other anticholinergics, Beta adrenergic drugs, Xanthine

Isosorbide Mononitrate

Phosphodiesterase inhibitors

Isotretinoin

Tetracyclines, Vitamin A

Lactulose

Drugs causing reduced potassium, Cardiac glycosides

Lamotrigine

Cytochrome P450 inducers or inhibitors

Lansoprazole

Cytochrome P450 inducers or inhibitors, Digoxin

Levetiracetam

Other antiepileptics, Probenecid, Methotrexate, Oral contraceptives

Levodopa

Antihypertensives, Antidepressants, Anticholinergics, Dopamine receptor antagonists, Benzodiazepines, Isoniazide

Levonorgestrel

Cytochrome P450 inducers or inhibitors

Levothyroxine

Anticoagulants, Antidiabetic agents, Tricyclic antidepressants, Beta blockers, General anaesthetics

Lithium

Antibiotics, NSAIDs, ACE inhibitors, Angiotensin 2 receptor antagonists, Diuretics, Steroids, Carbonic anhydrase inhibitors

Lorazepam

Alcohol, Sodium oxybate, HIV protease inhibitors

Losartan

Other antihypertensives, Cytochrome P450 inducers or inhibitors, NSAIDs

Memantine

Amantadine, Hydrochlorothiazide, L-dopa, Dopaminergic agonists, Antocholinergics

Metformin

Iodinated contrast agents

Methadone

MAOIs, Cytochrome P450 inducers or inhibitors, Opioid agonists, CNS drugs, Alcohol, Antibacterials, Antiretroviral HIV drugs, Anticonvulsants, Barbiturates, Cyclizine

Methylphenidate

MAOIs, Antihypertensives, Dopaminergic drugs

Metoclopramide

Dopaminergic agonists, Alcohol

Metronidaole

Anticoagulants, Lithium

Midazolam

Cytochrome P450 inducers or inhibitors

Mifepristone

Cytochrome P450 inducers or inhibitors

Misoprostol

NSAIDs

Morphine Sulfate

MAOIs, Gabapentin, Ritonavir, Rifampicin, Cimetidine, CNS depressants, Esmolol, Metoclopramide, Mexiletine, Voriconazole, Sedatives

Naproxen

Other NSAIDs, Cardiac glycosides, Ciclosporin, Corticosteroids, Antiplatelet agents, SSRIs, Bisphosphonates, Tacrolimus

Nitrofurantoin

Probenecid, Sulfinpyrazone

Norethisterone

St John's Wort, Corticosteroids

Olanzapine

Cytochrome P450 inducers or inhibitors