Drugs for Depression

Neurotransmitters involved in depression:

↓Norepinephrine, ↓Serotonin, ↓Dopamine

Drugs and Drug Classes FDA Approved for Depression

SSRIs
SNRIs
Serotonin Modulators
Norepinephrine Dopamine Reuptake Inhibitor (NDRI)-Bupropion

TCAs
MAOIs

SSRIs

citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline

SNRIs

venlafaxine, duloxetine

serotonin modulators

trazodone, vortioxetine, vilazodone

NDRI

bupropion

TCAs

amitriptyline, clomipramine, imipramine

MAOIs

phenelzine

NaSSA

mirtazapine

bipolar disorder neurotransmitters

↓GABA, ↑norepinephrine, ↑glutamate

Drugs approved for BD

• Mood stabilizers

  • Lithium

  • Seizure meds

  • 2nd gen antipsychotics

Seizure meds (BD)

Divalproex sodium, Lamotrigine

2nd gen antipsychotics

aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone

Drugs classes for ADHD

Stimulants

Non-stimulants

ADHD Stimulants 

Amphetamine and Methylphenidate

Non- stimulants

atomoxetine (SNRI)

clonidine/guanfacine (Alpha 2 agonist)

bupropion (NDRI)

Psychosis/ Schizo neurotransmitters

↑Dopamine in mesolimbic pathway (positive symptoms)

↓dopamine in mesocortical (negative/cognitive)

First Generation (Typical) Antipsychotic Medications:

Dopamine D2 receptor antagonists

• Phenothiazine Class

• Non-phenothiazine Class
  

Phenothiazine class antipsychotics (D2 antagonists):

Chlorpromazine, Fluphenazine, Perphenazine, Prochlorperazine, Thioridazine

Non-Phenothiazine class (Selective D2 receptor antagonists):

Haloperidol, Thiothixene

Second Generation (Atypical) Antipsychotic Medications mechanism:

Dopamine D2 receptor antagonists and selective serotonin antagonists

Second Generation (Atypical) Antipsychotic examples:

Aripiprazole, Olanzapine, Quetiapine, Risperidone, Ziprasidone, Clozapine, Lurasidone