Oncogene vs TSG

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8 Terms

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Oncogenes

Mutation in one of the two alleles is sufficient to produce oncogenic effects

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Oncogenes

Oncogenic effect is due to the gain-of-function of a protein that stimulates cell growth and proliferation

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Oncogenes

Mutations arise in somatic cells (not inherited)

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Oncogenes

Often demonstrate strong tissue preference with respect to the type of cancers in which they are found.

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Tumor Suppressor Genes

Mutations in both alleles are required to produce oncogenic effects

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Tumor Suppressor Genes

Oncogenic effect is due to loss-of-function of a protein that inhibits cell growth and proliferation

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Tumor Suppressor Genes

Mutations may present in germ or somatic cells (may be inherited)

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Oncogenes

Usually do not show tissue preference with respect to the type of cancer in which they are found.