multiple proteins form a pore in a plasma membrane so that EC fluid flows in and cell lyses
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histamine
induces constriction of blood vessels at wound, triggers phagocytosis through complement system
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toll-like receptors
fragment of bacterium binds to it, activates protein kinase cascade and causes shape change of transcription factor, transcription factor binds to promoters in nucleus
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leukocytes
white blood cells; second line of defense against pathogens
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phagocytes
ingest pathogens via phagocytosis
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mast cells
release histamine when damaged
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components of blood plasma
ions, small molecule solutes, solube proteins
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lymph
fluid derived from blood and other tissues, lacks red blood cells, found in lymph nodes and blood plasma
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defensins
made by mucus membrane, toxic to pathogens
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cytokines
produced in response to pattern recognition receptors (recognize nonself molecules), induce changes in T and B cells
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complement system parts
1. binding to components on pathogen’s surface to help phagocytes recognize pathogen 2. inflammation response activated and phagocytes attracted 3. inserting into cell membranes of pathogens and causing lysis
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allergic reactions
harmless nonself molecules bind to mast cells and cause inflammation
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autoimmune diseases
immune system can’t tell difference between self and nonself molecules, attacks body
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sepsis
inflammation spreads throughout body
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antigen
on pathogen, binds to a specific antibody and causes immune response
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epitote
specific site on antigen that is recognized by the immune system
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antibody
antigen binds to this, helps identify pathogens, produced by B lymphocytes
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immediate hypersensitivity
lots of IgE produced right away → activates mast cells to release histamine
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delayed hypersensitivity
antigen is taken up by antigen-presenting cells and reaction doesn’t begin until hours after exposure to pathogen
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passive immunity
pre-made antibodies are transferred to a different organism
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2 types of adaptive immunity system
humoral and cell-mediated (cellular)
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components of humoral system
antibodies and B cells
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components of cell-mediated system
T cells and T cell receptors
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what does the humoral system do?
creates antibodies to fight pathogens
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recognition phase in immune response
antigen inserted into membrane of antigen-presenting cell
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activation phase in immune response
T-helper cell recognizes the antigen, releases cytokines to stimulate B and cytotoxic T cells
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Effector phase in immune response
B cells make antibodies and attract phagocytes to pathogen (humoral), cytotoxic T cells bind to cells with antigen and destroy them (cellular)
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T-helper cell
T cell with a receptor for a specific antigen, activate adaptive immune system
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immunoglobulin/antibody structure
2 heavy and 2 light polypeptide chains with a minimum of 2 antigen-binding sites across the chains
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one antibody can bind to __ antigens
2
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classes of antibodies
IgG, IgM, IgD, IgA, IgE
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function of IgG
most abundant antibody in immune responses, provides immunity to fetus
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function of IgM
antigen receptor on B cells, first class released by B cells during primary response
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function of IgD
cell surface receptor on mature B cell, helps activate B cell
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function of IgA
protects mucosal surfaces and prevents attachment of pathogens to epithelial cells
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function of IgE
binds to mast cells and basophils to help induce antigen binding, which triggers histamine release
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cytotoxic T cells (Tc)
bind to pathogens displaying the antigen they are able to see, causes pathogens to die
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function of tregs
make sure immune system doesn’t spiral out of control
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function of memory cells
can be used to fight same antigens in future
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endocrine cells
secrete hormones into the blood, interact with neurons, slow and broadcast, prolonged
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paracrines
affect functions of cells around the cell that secreted them
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autocrines
affect the cell that released them
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pheromones
chemical signals that are released into the environment and impact other individuals of the same species