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Nerves
Bundles of axons and the glial cells which support them.
Nervous System
Network of neurons through the body that convey electrochemical information throughout the body.
Two Parts to Nervous System:
Central Nervous System
Peripheral Nervous System
Central Nervous System
Brain and Spinal Cord
Commands skeletal and muscular systems for action
Complex perceptual, motor, emotional, and cognitive functions.
Spinal cord branches down from the brain: nerves that process sensory information and relay commands to the body.
Peripheral Nervous System
Connects central nervous system to the body’s organs and muscles.
Peripheral Nervous System Two Parts
Somatic Nervous System
Autonomic Nervous System
Somatic Nervous System
Convey information between voluntary muscles and central nervous system.
Conscious control
Perceive → think → coordinate behaviours
Autonomic Nervous System
Involuntary and automatic commands that control blood vessels, body organs, glands,
Not in conscious control,
Two Parts
Two Parts of Autonomic Nervous System
Sympathetic and Parasympathetic
Sympathetic Nervous System
Prepares body for action in challenging situations.
Parasympathetic Nervous System
Helps the body return to a normal resting state, coordination of functions such as sexual activity
Spinal Reflex
Simple pathways in the nervous system that rapidly generate muscle contractions.
Reflex Arcs
Neutral pathways that control reflex actions.
Can include sensory neurons, interneurons, motor neurons.
Can also be simple and with only sensory and motor neurons.
Quadriplegia/Tetraplegia
Loss of sensation and motor neuron control in limbs due to a spinal cord injury.
Lower Brain Levels
Simpler function
Higher Brain Levels
Complex function
Networks
Interacting interdependent regions that work together to support complex psychological functions.
Hindbrain
Continuous with spinal cord
Coordinates information coming into and out of the spinal cord.
Medulla, Reticular formation, cerebellum, and Pons
Medulla
Extension of spinal cord into skull, coordinaates heart rate, circulation, and respiration.
Reticular Formation
Regulates sleep, wakefulness, and levels of arousal.
Site of anesthetic activity
Cerebellum
Large structure of the hindbrain that controls fine motor skills
Proper sequence of movements for skilled behaviour (Bike ride, playing piano)
Learning via fine-tuning of behaviour
Pons
Relays information from the cerebellum to the rest of the brain.
Midbrain
Tectum
Tegmentum
Tectum
Orients an organism in the environment.
Input from eyes, ears, skin
Tegmentum
Involved in movement and arousal.
Helps orient an organism toward sensory stimuli.
Forebrain
Complex cognitive, emotional, sensory, motor functions
Forebrain Parts
Cerebral cortex
Subcortical Structures
Thalamus
Hypothalamus
Cerebral cortex
Outermost layer of the brain, visible to the naked eye, divided into two hemispheres.
Subcortical Structures
Areas of the forebrain housed under the cerebral cortex near the center of the brain.
Thalamus
Relays, filters information from the senses. Transmits info to the cerebral cortex.
Closes pathways of incoming sensations during sleep.
(Like a bus station)
Hypothalamus
Regulates body temperature, hungers thirst, sexual behaviour.
Optimal range for normal human functioning,
Part of the limbic system
Limbic System
Group of forebrain structures involved in motivation, emotion, learning, and memory.
Limbic System Includes:
Hippocampus, hypothalamus, and amygdala
Hippocampus
Creating new memories, integrating them into a network of knoledge → indefinite storage in the cerebral cortex.
Damage ~ inability to cement new memories for facts and events
memory of learned habitual routines or emotional reactions may remain
Amygdala
Role in many emotional processes, including formation of emotional memories.
Attached significance to previously neutral events associated with fear, punishment, reward.
In emotional situations, amygdala stimulates hippocampus to remember details of the situation.
Alzheimer’s Disease
Progressive brain disorder that gradually impairs memory and other cognitive functions.
Leading cause of death in older adults.
90 million cases worldwide by 2050
More common among women than men.
Alzheimer’s Disease Affect on Physical Brain
Volume of hippocampus is reduced in AD
Volume decline is larger in women
Progression of volume decline is 1.5x faster in women
Possibly a reliable early indicator of AD onset in women, especially
Major Divisions of the Brain
Basal Ganglia
Striatum
Basal Ganglia
Set of subcortical structures that directs intentional movements.
Input from cerebral cortex
Outputs to motor centers in brainstem
Striatum
Caudate, putamen, ventral striatum
Controls posture and movement
Parkinson’s: midbrain supply dopamine to striatum is damaged causes tremor
Endocrine System
Network of glands that produce and secrete into the bloodstream chemicals known as hormones.
Thyroid
Regulates bodily functions like temperature and heart rate.
Adrennals
Regulate stress response
Pancreas
Controls digestion
Pineal
Secretes melatonin
Pituitary Gland
Master gland of body’s hormone-producing system, releases hormones that direct the functions of other glands in the body.
Receives hormonal signals from the hypothalamus.
Ovaries
Female sexual reproductive glands, making estrogen.
Testes
Male sexual reproductive glands, making testosterone.
Cerebral Cortex Texture
Gyri
Sulci
Gyri
Smooth raised surfaces, singular gyrus.
Sulci
Indentations, singular sulcus.
The Cerebral Cortex Across Hemispheres
Contralateral control
Commissures
Corpus callosum
Contralateral control
Left and right hemispheres control the functions of the opposite side of the body.
i.e. right hemisphere percieves left side stimuli…
Comissures
Connect left and right hemisphere, bundles of axons that communicate between each hemisphere.
Corpus Callosum
Connects large areas of the cerebral cortex between the hemispheres.
Cerebral Cortex Within Hemispheres
Occipital Lobe
Parietal Lobe
Occipital Lobe
Processes visual information
Parietal Lobe
Processes information about touch
Somatosensory cortex is strip of brain tissue on the front of the parietal lobe and represents contralateral surface body.
Homunculus
Somatosensory cortex can be illustrated as homunculus: body parts rendered according to how much of the somatosensory cortex is devoted to them.
Motor Cortex
Initiation of voluntary movements
Temporal Lobe
Responsible for hearing and language.
Primary auditory cortex
Primary auditory cortex
Receives information from the ears based on sound frequency…..
Frontal Lobe
Specialized areas for movement, abstract thinking, planning, memory, judgement.
Contains motor cortex.
Manipulate information, retrieve memories, plan behaviours, interact socially…
Association Areas
Composed of neurons that help provide sense and meaning to information in the cortex.
Mirror Neurons
Active when an animal performs a behaviour or observing the same behaviour
Plasticity
Small changes can happen in the nervous system.
Phantom Limb Syndrom
Amputees experience sensations where the missing limb would be.
The Influence of Practise
Musicians ~ more plasticity in motor cortex than non-musicians → increased number of motor synapses
Taxi drivers, overdeveloped hippocampi ~ spatial navigation
Exercise maximizes plasticity, increases # neurons in hippocampus
Invertebrates
Animals without a spinal column.
Evolutionary split in brain development.
Vertebrates
Animals with a spinal column
Evolutionary split in brain development
Chronic Traumatic Encephalopathy (CTE)
Progressive brain damage like repeated concussions lead to reduced brain size.
Cognitive and emotional deficits.
Memory loss, depression, etc.
Neuron
Cell in the nervous system.
Communicates with others for information-processing.
Santiago Ramon y CAJAL (1852-1934)
Golgi staining technique
highlighted entire cells
Does not stain every cell
Neuronal contact → neurons do not touch
Three Basic Parts to a Neuron
Cell body/soma,
Dendrites
Axon
Myelin Sheath
Demyelinating diseases
Synapse
Cell Body/Soma
Largest component of neurons, coordinates information-processing tasks, keeps the cell alive.
Protein Synthesis, energy production, metabolism.
Contains Nucleus (DNA)
Enclosed by porous cell membranes
Dendrites
Receive information from other neurons and relay it to the cell body.
Axon
Carries information to other neurons, muscles, or glands.
Myelin Sheath
Insulating layer of fatty material that covers many neurons.
Made of glial cells which are found in the nervous system.
Digest parts of dead neurons, provide physical and nutritional support.
Demyelinating Diseases
Multiple sclerosis → myelin sheaths deteriorate then neural communication slows down, loss of feeling in limbs, partial blindness, deficiencies in movement, cognition.
Synapse
Junction or region between the axon of one neuron and the dendrites or cell body of another.
Three Major Types of Neurons
Sensory neurons
Motor neurons
Interneurons
Sensory Neuron
Receive information from external world, convey this info to the brain (via spinal cord). Special ending on the dendrites allows for touch, smell, taste, sound, light…
Motor Neuron
Carry signals from spinal cord to muscles → movement
Interneurons
Connect sensory neurons, motor neurons, other interneurons.
Most neurons are interneurons.
Neuron Specialized Tasks
Purkinje cells
Pyramidal cells
Bipolar cells
Purkinje cells
Interneuron carrying information from cerebellum to the rest of the brain and spinal cord.
Dense and elaborate dendrites like a tree.
Pyramidal cells
Cerebral cortex, triangular cell body, single long dendrite and many smaller dendrites.
Bipolar cells
Sensory interneuron in retina, long dendrite and long axon.
How does information in the nervous system travel?
Electrochemically
How are electrical signals conducted?
They are conducted down axons to their terminal ends.
Chemical signals are __________ from one neuron to another across a __________.
Transmitted … synapse
Why is neuron cell membrane permeable?
To allow ions in and out of the cell
The permeability is the basis for conduction of an electrical signal.
Resting Potential
Electric charge at rest
Discovered in squid first
~ -70 millivolts
Inside Membrane: Resting Potential
High concentration of k+
Larger negatively charged proteins A-
Outside Membrane: Resting Potential
High concentration of Na+, Cl-
Why no concentration gradient?
Active pumps maintain high concentrations of k+ inside and Na+ outside creating potential energy.
Some K+ and Na+ channels are voltage-gated.
Action Potential
An electric signal conducted along the length of a neuron’s axon to a synapse.
When do APs (action potentials) Happen?
Action potentials only occur when stimulation reaches threshold.
What happens at the peak of Action Potential?
Na+ voltage-gated channels open.
Refractory Period
The time following an action potential when a new action potential cannot be initiated.
Limits the number of APs possible in a sequence.