The human body maintains a core temperature of about 98.6 degrees Fahrenheit (37 degrees Celsius). When overheated, thermo-sensors in the skin and brain sound an alarm, initiating a chain reaction that directs the body to sweat and flush. When chilled, the body responds by shivering, and reducing blood circulation to the skin. Similarly, when sodium levels spike, the body signals the kidneys to conserve water and expel excess salt in concentrated urine. These are examples of \__________.