Composed of central system and the peripheral system
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Central nervous system
Comprised of brain and spinal cord
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Peripheral nervous system
Set of nerves that connects the CNS to the sensory organs, muscles, and glands; everything except brain + spinal cord; two main kinds of nerves that serve different tasks
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Sensory neurons
Has to send information up to brain about what you touch
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Motor neurons
Take commands from brain and send them to various parts of body
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Sympathetic system (arousing)
Active when you are in some sort of arousing situation; marshal resources (accelerate heartbeat, etc.) as way of handling emergency
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Parasympathetic system (calming)
Active when you are calm, at rest; relaxed (slow heartbeat, etc.), regular housekeeping/maintaining processes; stimulates digestive process, other activities that help regenerate/vitalize body
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Two divisions of automatic nervous system
Sympathetic and parasympathetic; both active simultaneously
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Spinal cord
Consists of bundles of nerves called tracts
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Ascending tract
Carries sensory information brought in by spinal nerves up to the brain
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Descending tract
Carries motor-control information down from the brain to be transmitted out by spinal nerves to muscles
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Spinal cord injury
Unable to feel or move anything connected to body parts that are activated by spinal cord
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Brainstem
Responsible for automatic survival functions, such as controlling breathing and heartbeat
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Brainstem injury
Fatal injury
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Cerebellum
Motor control, posture, balance, important for rapid, well-timed movements; in back of brain stem
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Thalamus
Sensory relay station that receives input from most of sensory modalities → goes to rest of brain; vision, audition, etc.; does not process smell; relay station, input to other parts of brain that specialize in processing sensory information
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Basal ganglia
Involved with motor control, especially intentional movements; slow, controlled movements; opposite of cerebellum; slow, deliberate motor movements
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Basal damage
Produces "tremor at rest"; Parkinson's disease affects nerves running into this; cannot regulate hands in slow, fine-tuned way
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Hypothalamus
Regulates many basic body functions, such as hunger, thirst, sleep, body temperature; motivation
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Hypothalamus injury
Inability to sleep in certain way, inhibit/amplify feeling of hunger
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Amygdala
Emotional regulator; one of key roles is processing and regulating emotional states; basic emotions require this; allows us to recognize emotions in other people; definitely involved with fear
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Amygdala injury
Loss of "normal" emotion
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Hippocampus
Key for building long-term memories; allow to learn, acquire new/encoding conscious memories; can't be where long-term memories are permanently stored
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Hippocampus injury
Unable to acquire long-term memories, even though they retain memories prior to damage
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Cerebral cortex
Outermost layer and largest part of brain, accounting for roughly 80% of total volume; ⅓ is visible, remaining ⅔ is hidden within many folds and fissures; divided into left and right hemispheres; four lobes/quadrants on each side
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Principles of brain organization
Specialization of function; size/function correlations in functional areas; contralateral organization
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Specialization of function
Bodily sensations (parietal lobe); speaking, imagining, thinking (frontal lobe); hearing and language comprehension (temporal lobe); vision (occipital lobe); widespread throughout brain
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Motor cortex
Also called primary motor area; located at rear of frontal lobes and controls voluntary movements
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Sensory cortex
Called primary somatosensory area; located at front of parietal lobes and registers body sensations
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Size-function correlation
Sensitivity and function of body part depending on "real estate" devoted
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Contralateral organization
Most of sensory and motor information that travels to and from brain goes to the opposite sides of body
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Motor crossover
Sensory information coming from the right side of the body crosses by the left hemisphere, v.v.; motor control crosses from right hemisphere to left side of body, v.v.
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Visual crossover
Left visual field to right hemisphere; right visual field to left hemisphere; within each eye
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Corpus callosum
Large bundle of neural fibers (axons) connecting two brain hemispheres; main pathway that links and sends communication between two hemispheres
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Left hemisphere
Language, right side of body, right visual field
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Right hemisphere
Left side of body, left visual field
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Aphasia
Impairment of language, usually caused by left hemisphere damaged to either Broca's area or Wernicke's area
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Frontal lobe function
Involved with higher-level reasoning, ability to inhibit distracting/profane events, personality
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Subcortical structures
Corpus callosum, thalamus, hypothalamus, brainstem, basal ganglia, cerebellum, hippocampus functions
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Primary motor area
Basic command signals to move basic muscle parts; located in back of frontal lobe; map of body laid out
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Primary sensory area
Processes basic information received from part of body; map of body laid out
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Egas Moniz
Beneficial to put little rod up into frontal lobe through eye and disrupt connections in frontal lobe to treat illness like schizophrenia; gave us knowledge of function of frontal lobes; invasive brain manipulations with psychosurgery
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Issues in brain imaging
Spatial and temporal resolution
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Spatial resolution
How close in physical proximity can you get to target brain area activity
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Temporal resolution
How close in time you can get to when the neurons communicate with each other
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Electroencephalography
Measures electrical signals associated with neural firing in brain areas; excellent temporal resolution, poor spatial resolution, non-invasive; communication in brain in part involves electrical signals
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Computed tomography scan
Version of X-ray; provides information about brain structure; air spatial resolution, no temporal resolution
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Magnetic resonance imaging
Going into a gigantic magnetic machine to provide image; excellent spatial resolution, no temporal resolution, non-invasive
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Functional MRI
Based on changed in oxygen consumption and blood flow, which are byproducts of neural activity; excellent spatial resolution, good temporal resolution, making inferences on activity; blood to some extent magnetic → brains that are active will have slightly more blood flow
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Santiago Ramon y Cajal
Made cellular study of brain possible; using primitive microscope, identified basic shape of nerve; coined term "neuron"; realized it is basic building block of brain, elementary communication unit
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Three major classes of neurons
Sensory, motor, interneurons
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Sensory neurons
Receive information from senses, bring it up to brain; send input from sensory areas to brain and spinal cord
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Motor neurons
Take motor commands from brain and send it down to body parts; send output from the brain spinal cord to muscles and glands
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Interneurons
Connect one neuron to another, carry information between; carry information between other neurons; only located within brain
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Structure of neuron, three basic parts
Dendrites, cell body, axon
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Dendrites
Bushy, branching extensions of neuron that receive messages and conduct impulses toward cell body; the tree's roots; basic receiving unit
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Axon
Extension of neuron, ending in terminal fibers, through which messages are sent to other neurons or to muscles or glands; one per cell, two distinct parts: tubelike structures + branches at end that connect to other cells; myelin sheath
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Myelin sheath
White fatty casing on axon made of glial cells; acts as electrical insulator; increases speed of neural signals down the axon; whiteness of fatty cells that gives rise to "white matter"
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Action potential
Basic communication element of all of us, fundamentally important; unidirectional; enhanced by myelin; synapse separating neurons; combination of electrical signal and chemical through synapse
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Synapse
Gap between axon tip of sending neuron and dendrite/cell body of receiving neuron; chemicals sending action potential to neuron
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Neurotransmitter
Chemical messengers that traverse synaptic gap between neurons; effect on receiving neuron can either be excitatory (more likely to fire) or inhibitory (less likely to fire); communicate by mixture of electrical and chemical processes
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SSRI
Selective serotonin reuptake inhibitor; treat depression, selective to serotonin; more serotonin left in synapse → more opportunity for neuron to receive it
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Agonist
Drugs that increase effect of neurotransmitter
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Antagonist
Drugs that interfere with effect of neurotransmitter
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Neural development
Some takes place in womb and continues after birth until age 18 or so; occipital lobes finish developing first and the frontal lobes finish last
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Plasticity
Neural tissue can reorganize in response to damage, if the brain is still developing; "wiring up" is not hard-wired, influenced by experience and brain damage
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Sensation
Construction of "reality"; process by which sensory organs gather information about environment and transmit it to the brain; message that brain receives from one of senses
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Stages of sensation
Stimulation → transduction → transmission → representation in brain
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Transduction
To transform physical stimuli in the environment into neural signals in the brain
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Six major senses
Taste, smell, hearing, touch, pain, vision
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Taste
Bitter, sweet, salty, sour, umami
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Taste receptors
Each taste bud has 50-150 receptor cells → send information to gustatory sensory neurons; sides of mouth, most on tongue
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Smell
Chemical receptors in the nose, olfactory epithelium; fundamentally tied to taste
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Frequency
Related to pitch of sound wave
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Amplitude
Related to loudness of sound wave; high/low
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Hertz
Unit of frequency
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Major structures of ear
Outer, middle, inner ear
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Outer ear
Acts as a funnel to direct sound waves towards inner structures
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Middle ear
Consists of three small bones (or ossicles) that amplify the sound
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Inner ear
Contains the structures that transduce sound into a neural response
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Chlochea
Filled with fluid, lined with hair cells that are key to transducing sound waves into neural signal; higher pitched on outside, deeper on inside; stirrup pushes against oval window that fluctuates depending on pitch sound → fluid moves and activates hair cells → how brain interprets corresponding pitch
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Hair cells
Once cells are gone, they never recover; cells highly correlated with age, systematically go away; higher pitched cells destroyed quicker, on outside
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Touch receptors
Sensory neurons all over skin
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Neural pathways that code pain
A-delta and C-fibers
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A-delta fibers (myelinated)
Thick, fast conducting neurons; quick, sharp pain; comes first
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C-fibers (unmyelinated)
Thin, slow conducting neurons; slow, throbbing pain; comes last
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Gate-control theory
Explains variability in experience of painful events; argues that spinal cord contains a neurological "gate" that blocks pain signals or allows them to pass on to the brain; one same wound may not feel as painful as another due to context and release of endorphins
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Phantom limb pain
Experience of pain not always originate from pain receptors, can be generated from brain
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Purpose of visual system
To transform light energy into a neural impulse; represent characteristics of objects in our environment such as size, color, shape, and location
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Compound eyes
Multiple lenses; very sensitive to motion, acuity good; inefficient for resolution
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Simple eyes
Single lens; works like an old-fashioned camera, using lens to focus light onto photo-sensitive surface at back of sealed structure
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Retina
At back of eye, consists of series of layers; rods + cones most important part: receptor cells that do transduction work; light shine through layers of retina to rods and cones that convert light energy into signal brain can understand; sends signal to optic nerve
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Rods and cones
Photoreceptors which transduce energy in light into neural response
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Cones
Permit color vision and are most concentrated in fovea (pinhead-size area of retina that is in most direct line of sight)
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Rods
Permit vision in dim light and are in everywhere except in fovea, distributed basically everywhere in retina
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Blind spot
Region with no rods or cones; relatively sizeable
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Electromagnetic spectrum
We only see sliver of huge dimension of wavelengths, this
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Key aspects of light
Visual system interprets differences in wavelength of light as color; visual system interprets differences in the amplitude of light as intensity
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Opponent Process Theory
Account for phenomena like complementary afterimages, Ewald Herring proposed that we have different types of color-opponent cells; red-green, blue-yellow, black-white opponent cells
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Primary visual area/cortex
First region that receives visual information in occipital lobe; very rudimentary way, cells within primary region that are sensitive to very simple features in the world