pharma

Answer: Gabapentin

This drug is originally an anti-seizure

drug but is used as an adjunct to

treat spasticity

Answer: Diazepam

A patient on antipsychotic

medication who underwent physical

therapy developed neuroleptic

malignant hyperthermia. Which of

the following will help this pt. ?

Answer: α

The following are opioid receptors

except:

Answer: Meperidine

The following is/are strong opioid

agonist/s

Answer: A. Pentazocine

Which of the following is a mixed

agonist-antagonist?

Answer: B. Naloxone

A drug that can be used to reverse

the respiratory depression caused

by strong opioid agonists.

Answer: Glutamate

The following are inhibitory

neurotransmitters in the dorsal horn

EXCEPT:

Answer: A. Dynorphin

Opioid peptide that act primarily on k

receptor

Answer: C Morphine

Considered as the reference opioid

Answer: C Kidneys -

increased tubular sodium

reabsorption

Which of the following is NOT an

effect of opioids

Answer: B Naloxone

Primary Intervention for treating

opioid addiction

Answer: B. Dependence

Physiological state of

neuro-adaption produced by

repeated administration of a drug,

necessitating continued

administration to prevent the

appearance of the withdrawal

syndrome

Answer: B. Liver

Metabolism of opioids occur in

Answer: A. Urine

Excretion of opioids primarily occur

via the

Answer: Cyclooxygenase

NSAIDS inhibit which of the

following enzymes?

Answer: Prostaglandin

The anti-inflammatory effect of

NSAIDS is due in part to reduced

production of

Answer: Aspirin

The oldest NSAID

Answer: Aspirin

NSAIDs that is/are contraindicated in

fever caused by viral infection

especially in children

Answer: Celecoxib

Selective COX2 Inhibitor

Answer: Acetaminophen

NSAID that lacks anti-inflammatory

effect

Answer: NAPQ1

Toxic metabolite/s of paracetamol

that cause hepatotoxicity

Answer: Less sedating

Antidote for paracetamol overdose

or poisoning

Answer: Indomethacin

Advantage of selective COX2

inhibitors

Answer: Indomethacin

NSAID used to accelerate closure of

PDA

Answer: Uric Acid crystals

Gout is due to the accumulation of

____ in joint spaces

Answer: Indomethacin

Non-NSAID drug used for treatment

of acute gouty attack

Answer: Allopurinol and

Colchicine (A & B only)

This drug reduces uric acid

synthesis

Answer: Naloxone,

Naltrexone, Nalmiphene

(All of the Above)

Pure opioid antagonist

Answer: Aspirin

This NSAID is used prophylactically

to prevent recurrence of TIA or MI

Answer: male, alcohol

intake, male gender (ALL

OF THE ABOVE)

Which of the ff is/are risk factor/s for

gout?

Answer: aspirin

Irreversible inhibitor of COX

Answer: Nabumetone

The only NSAID that is not acidic

Answer: celecoxib

A 65 y/o man had been recently

diagnosed with osteoarthritis. 6 mos

age, he suffered from peptic ulcer

disease that healed after triple

antiulcer therapy. Which of the ff

non-steroidal anti-inflammatory

drugs would be most appropriate for

this pt?

Answer: Prostaglandins

and bradykinin

○ Possible answer:

Prostacyclin and

Thromboxane

100. 63 y/o woman recently dx w

osteoarthritis started treatment with

ibuprofen. The biosynthesis of which

of the following pairs of endogenous

compounds most likely inhibited by

the drug?

Answer: A. Endorphin

Which of the following endogenous

opioid has the greatest affinity for

mu receptor

Answer: B. Morphine

Which of the following is the

reference opioid?