Leukocyte Production and Normal Cell Morphology

what is it

common myeloid progenitor

what is it

myeloblast

what is it

promonocyte

what is it

monocyte

what are the 2 WBC circulatory systems

1. The Circulating Pool (CP)

2. The Marginated Pool (MP)

what WBC circulatory pool is pulled from when drawing blood

The Circulating Pool (CP)

The —- usually comprises about 50% of the total WBC in the blood vessels in dogs, calves and horses.

The Circulating Pool (CP)

White blood cells in the Marginated Pool are cells that are

stuck to or rolling along the inside walls of the blood vessels.

how much of WBC is marginated in cats

75%

why can cat WBC be high

cats can shake off marginated cells and so when u take blood its sky high white blood cells

define Granulopoiesis

The production of granulocytes

what are 3 Granulocytes made from Granulopoiesis

1. neutrophils

2. eosinophils

3. basophils

In the bone marrow there are 3 functional compartments or pools of granulocytes.

1. Mitotic pool

2. The maturing pool

3. Storage pool

define mitotic pool

contains cells capable of undergoing mitosis (cell division).

what granulocytes are in the mitotic pool (3)

1. Myeloblast

2. Promyelocyte

3. Myelocyte

what is it

myeloblast

what size are myeloblast

14 to 20 um in diameter.

what is it

promyelocyte

what is it

myelocyte

define maturing pool

The maturing or post–mitotic pool contains cells that are immature, but no longer undergo mitosis.

what granulocytes ate in the maturing pool

1. Metamyelocyte

2. bands

define storage pool

The storage or reserve pool which contains mature granulocytes waiting to be released into the blood.

what animal is it from

canine

what animal is it from

feline

what animal is it from

bovine

what animal is it from

equine

what are the 2 types of agranulocytes

1. monocyte

2. lymphocyte

where are monocytes produced

bone marrow

how long do monocytes circulate in the blood for (range)

1 - 2 days

what happens to monocyte after its done circulating (2)

1. enter tissues

2. become macrophages

macrophage are aka

mononuclear phagocytes

what are the 2 type of macrophages

1. Free or wandering macrophages

2.  Fixed Macrophages

where are Free or wandering macrophages found (3)

1. body cavities

2. alveoli

3. sites of inflammation

define Free or wandering macrophages

they can move from one tissue to another.

define Fixed Macrophages

reside in a specific tissue type and are not motile.

what are some tissues that have macrophages (5)

1. liver = Kupffer cells.

2. spleen

3. bone marrow

4. lymph nodes

5. gastrointestinal tract

what are the types of cells under monocytes (3)

1. Monoblast

2. Promonocyte

3. macrophage

what animal is it

bovine

what animal is it

canine

what animal is it

feline

what animal is it

equine

where do lymphocytes come from

bone marrow

B-Lymphocytes originate and mature in the

BM

T-Lymphocytes originate in the — and then migrate to the —-

BM, thymus

Most of lymphocytes travel via the —- to the — tissue. 

blood, lymphoid

B and T lymphocytes become (2)

B-cells and Natural Killer Cells.

Lymphocyte production is stimulated by the presence of — in the body.

antigens

size of small lymphocytes (range)

8 - 11 um

what animal is it

bovine

what animal is it

canine

what animal is it

feline

what animal is it

equine

Small lymphocytes are either — or — cells

B, T

B lymphocytes are

memory cells

T lymphocytes are

fighter cell

what is the size of large lymphocytes (range)

14 to 18 um in diameter.