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genome definition
the complete set of DNA instructions for an organism
daughter cells
the resulting cells of mitosis
chromosomes
how DNA is packaged in a cell to prepare for cell division
chromatin
when the DNA is not packaged into chromosomes
histones
proteins that DNA wraps around
somatic cells
cells that have a full set of chromosomes
diploid
2N
46 chromosomes in humans
made through mitosis
replication
copies of DNA are made
occurs during S phase of interphase
in the neucleus
sister chromatids
either side (2 identical copies) of a single replicated or duliplicated chromosome
cell cycle
a highly regulated series of events for the growth and reproduction of cells
interphase
growth and preparation
mitosis
division of the neucleus
cytokenesis
division of the cytoplasm
mitotic spindle fiber
made up of microtubes
orginiate from centrosomes
attach to kinetochores on either side of centromere
what is the end result of mitosis
2 identical daughter cells
cytokinesis in animal cells
cleavage furrow
definition of cleavage furrow
pinching off of the cytoplasm to seperate animal cells
cytokinesis in plant cells
cell plate
G0
a resting phase where a cell is not dividing or preparing to divide
how is the cell cycle regulated
internal controls or checkpoints regulate progression through the cell cycle
M-spindle
checks for spindle attachment to chromosome
between metaphase and anaphase
MPF allows cell to proceed past checkpoint
G1
At the end of g1, after s phase
checks for cell size, nutrients, growth factors, dna damage
G2
at the end of g2, before mitosis
checks for dna damage and dna replication
cyclins
a group of related proteins associated with specific phases of the cycle
cyclin dependent kinases
a group of enzymes involved in cell regulation
requires cylin binding for activation
MPF (mitosis premoting factor)
MPF
triggers the cell’s passage past the g2 checkpoint into mitosis
is a CDK with M cylin activating it
density-dependent inhibition
crowded cells stop dividing
cells will stop going through the cell cycle when they have reached a certain density
anchorage dependence
cells must be attached to a substration (solid surface) to survive, grow, and divide
cancer cells
exhibit neither density dependent inhibition nor anchorage
checkpoints in the cells are not functional
when cells begin to divide the organism has
cancer
if a caner does not grow larger
benign
abnormal cancer cells tend to pile up on each other to form a
tumor
apoptosis
programmed cell death
what is meiosis
ensures the formation of haploid gamete cells in sexually reproducing diploid organisms
outcomes of meiosis
results in daughter cells with half the number of chromosomes as the parent cells
ensures genetic diversity in sexually reproducing organisms
gene
a portion of DNA that codes for a specific protein on a chromosome
locus
location of a gene on a chromosome
zygote
when gametes, sperm and egg, fuse to form a diploid cell
will go through mitosis to develop into an adult organism
autosomes
carry the same characteristics in males and females
sex chromosomes
different from each other in their characteristics. are represented as X and Y.
2 in humans
determine the biological sex of an individual
XX is female XY is male
homologous chromosomes
a pair of autosomes
tetrad
mom + dad’s chromosomes (duplicated)
meiosis ensures that
each gamete recieves one complete haploid (N) set of chromosomes
meiosis 2 does not go through
interphase
what are the 3 ways meiosis produces genetic variation
independent assortment
crossing over
random fertilization
independent assortment
homologous pairs of chromosomes arrange/orient themselves randomly when they line up in M1
either chromosome can go to either side
crossing over
homologous chromsomes physically connect and exchange genetic information
random fertilization
the fusion of gametes
any sperm can fertilize any egg
provides combinations of genetic information in the zygote