Clinical use of Induction Agents

What cardiovascular effects of propofol?

Vasodilation and poss bradicardia

What are Resp effects of propofol?

Depression

Hypoventilation and apnea

What effects does propofol have on the CNS?

Depression

GOOD for head trauma and anticonvulsant

What affect does propofol have on the muscles?

Relaxation

Myoclonic movements

Propofol has no ____ effect?

Analgesic

What are pharmacokinetics of Propofol?

Rapid metabolism

IV only but slow

Onset in 20-30s

Short duration - 5-10mins

When we give propofol CRI what happens?

It accumulates and delays recovery

What are CV effects of Alfaxan?

Vasodilation

HR (maintained/ increased)

What are resp effects of alfaxalone?

Depression

Hypoventilation

Apnea

What are CNS effects of Alfaxalone?

CNS Depression

Decreased intracranial pressure

What Muscluloskeletal affects are seen w/ alfaxalone?

Relaxation

Myoclonic twitching

Alfaxan will have no _____?

Analgesia

What are pharmacokinetics of Alfaxan?

Rapid metabolism

IM/IV

Onset in 45-60s

Duration of 7-10mins

What are CV effects of Etomidate?

Minimal effect - drug for cardiac pts

What effects can we see in the resp system if Etomidate is used?

Minimal effects

-Can see resp depression and apnea

What are CI of etomidate?

Addisons DZ and Critically ill

-Adrenocortical suppression

What must etomidate be combined w/?

Muscle relaxant - myoclonus tremors

Etomidate should be given IV ____ and avoided being given via___?

Slowly

CRI

What are two forms of dissociative induction drugs?

Ketamine and teletamine

What are the affects of Ketamine on the CV?

Sympathetic stimulation (increase hr and vasoconstriction)

- arrhythmia

What are resp effects of ketamine?

Bronchodialation / apneuistic breathing patterns

What we se in regards to musculoskeletal and nervous system of ketamine?

Reflexes are intact

Maucle rigidity

What urinary issues w/ ketamine do we need to understand w/ cat?

Urinate out active metabolite norketamine

-CRF may impact metabolism/ elimination

Unlike other induction agents ketamine will have ____ effects?

Analgesic

What animals will we avoid using telazol in?

Tigers -sudden death